Byooviz (ranibizumab-nuna) is a brand-name drug prescribed for certain eye conditions in adults. It comes as a liquid that’s given via eye injection by a doctor. The frequency of injections may depend on certain factors.

The Food and Drug Administration (FDA) has approved Byooviz to help treat these vision-related conditions:

Byooviz is a biologic. It belongs to a drug class called vascular endothelial growth factor (VEGF) inhibitors (anti-VEGF drugs). Byooviz is an interchangeable biosimilar of Lucentis.

Keep reading for specific information about the dosage of Byooviz, including its strength and how to use the medication. For a comprehensive look at Byooviz, see this article.

Note: This article describes typical dosages for Byooviz provided by the drug’s manufacturer. However, your doctor will prescribe the Byooviz dosage that’s right for you.

Below is information about the form, strength, and dosages of Byooviz.

Byooviz form

Byooviz comes as a solution in a single-dose vial that’s given as an eye injection. These injections are called intravitreal injections and they’re administered by an eye doctor.

Byooviz strength

Byooviz comes in one strength. Each vial has 0.5 milligrams (mg) per 0.05 milliliters (mL) of solution. The concentration is 10 mg/mL.

Typical dosages

The following information describes dosages that are commonly used or recommended. However, your doctor will determine the best dosage to fit your needs.

Some of the conditions below can affect both eyes. Byooviz is injected into the affected eye or eyes. Your doctor will determine whether you’ll need to treat one eye or both with Byooviz.

Dosage for myopic choroidal neovascularization

Byooviz is approved for the treatment of myopic choroidal neovascularization. The recommended dose is one injection (0.5 mg/0.05 mL) each month (every 28 days) for up to 3 months. Your doctor will check your condition and vision after the treatment. If they decide it’s needed, they may repeat your treatment.

Your doctor can tell you more about how many treatments you may need. Talk with your doctor if you have questions about your dosage.

Dosage for wet age-related macular degeneration

Doctors may use Byooviz to treat wet AMD. The recommended dose of Byooviz for wet AMD is one injection (0.5 mg/0.05 mL) per month. You’ll typically receive your treatment about every 28 days.

However, other dosing schedules may be used for wet AMD, at your doctor’s discretion. Usually, the goal of treatment is maintaining visual acuity (your vision’s precision).

There may be certain situations where your doctor will recommend giving you Byooviz every 3 or 4 months.

Your doctor will assess your vision and choose a dosing schedule that suits your needs. For more information about your specific dosage, talk with your doctor.

Dosage for macular edema following retinal vein occlusion

Byooviz is also approved to treat macular edema following RVO. In this case, the recommended dose is one injection (0.5 mg/0.05 mL) each month, about every 28 days.

Talk with your doctor if you have questions about your dosage.

Long-term treatment

Byooviz is sometimes prescribed as a long-term treatment. It’s generally used long term for wet AMD and macular edema following RVO. If you’re treating either of those conditions, and Byooviz is safe and effective for you, you’ll likely receive it long term.

Treatment for myopic choroidal neovascularization with Byooviz may be shorter, generally lasting up to 3 months. However, it may take longer if your doctor recommends repeating treatment.

Before treatment, your doctor will discuss your condition and treatment plan with you. Ask your doctor about how long you can expect to take Byooviz.

Each Byooviz vial contains a single dose of solution. A separate vial is used for each eye. The drug will be drawn out, into a syringe. You’ll receive it as an intravitreal injection (an injection into the eye). Your eye doctor will give you the injection at their office. Before your treatment, your doctor will check your vision and the pressure within your eye.

Your doctor will use a tool to keep your eye open for the injection. They’ll clean your eye to prevent infection and numb your eye for the injection. They’ll also prepare your injection. These steps will be repeated if both eyes are being treated.

After the injection, your doctor will need to monitor you. During this time, they’ll tell you what to watch for after your injection. For example, if you have altered vision or a painful, red, or light-sensitive eye, you should seek immediate eye care.

Your doctor will recheck the pressure in your eye about 30 minutes after the injection. They may also run more eye tests to be sure the injection went well.

If you have questions about how Byooviz is given, talk with your doctor.

If you miss your Byooviz injection appointment, call your doctor’s office to reschedule as soon as possible.

To help keep track of your appointments, try downloading a reminder app on your phone. You can also write yourself calendar reminders about your injection schedule.

Below are some frequently asked questions about Byooviz.

Is the dosage of Byooviz similar to the dosage of Eylea?

In some ways. Both are intravitreal injections (an injection into the eye) that come in single-dose vials. However, Eylea (aflibercept) also comes in prefilled syringes. The dose in mg for each drug differs as they have different active ingredients.

Both drugs treat wet AMD, but they use slightly different recommended dosing. Both start out as one injection each month. However, after 3 months, Eylea’s recommended dosing shifts to once every 8 weeks (2 months). The drugs have similar dosing for macular edema following RVO. For this use, both drugs are given as one injection about once per month (every 4 weeks or 28 days).

Eylea is also prescribed for other uses. To learn more about all of Eylea’s dosages see this article.

Your doctor will prescribe the drug and dosage that’s right for you. To learn more about how these drugs compare, talk with your doctor.

How long does it take for Byooviz to start working?

Byooviz starts to work after the first treatment, but you may not notice its effects. For some people, their vision improves while receiving Byooviz. However, for many people, Byooviz simply keeps their vision from getting worse. If Byooviz stops your vision from getting worse, you may not notice a change. If your vision improves, it may take several months before you notice.

Your doctor will use regular eye exams to monitor your eyes during treatment. This is likely how you’ll know whether Byooviz is working to treat your condition.

Talk with your doctor if you have questions about what to expect with Byooviz treatment.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Byooviz for you, they’ll prescribe the dosage that’s right for you.

If you have questions about the dosage of Byooviz that’s best for you, talk with your doctor.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.