Lumakras (sotorasib) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat non-small cell lung cancer (NSCLC) that’s locally advanced or metastatic.* It’s used in adults who:

  • have NSCLC that has an abnormality in a gene called KRAS G12C, and
  • have tried a systemic treatment already

Lumakras comes as an oral tablet. It belongs to a drug class called RAS GTPase inhibitors. At this time, Lumakras is only available as a brand-name drug, not a generic.

* Lumakras received accelerated approval from the FDA. Accelerated approval is based on results of early clinical trials of the drug. The FDA will decide on full approval of Lumakras after more trials are done.

Dosage summary

The following chart summarizes Lumakras’s dosage. Your doctor will determine the dosage that’s best for you.

Lumakras formLumakras strengthTypical dosage
oral tablet120 milligrams (mg)960 mg (8 tablets) per day

For information about the dosage of Lumakras, including its strength and how to take the drug, keep reading. For a comprehensive look at Lumakras, see this article.

Below is information about the recommended dosage of Lumakras.

Lumakras form

Lumakras comes as an oral tablet.

Lumakras strength

Lumakras comes in a strength of 120 milligrams (mg) per tablet.

Typical dosage for non-small cell lung cancer

The following information describes the dosage that’s commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

The recommended dosage of Lumakras is 960 mg taken once daily. This is a total of 8 tablets per day.

Long-term treatment

Lumakras is meant to be a long-term treatment. If you and your doctor determine that this drug is safe and effective for you, you’ll likely take it long term.

The Lumakras dosage your doctor prescribes will depend on several factors. These include:

  • any side effects you experience
  • other medical conditions you have

Dosage adjustments

If you have certain side effects of Lumakras, your doctor may recommend lowering your dose to try and decrease your side effects. These side effects include:

You’ll typically take 8 Lumakras tablets once per day. It may be helpful to take Lumakras around the same time of day. This helps maintain a steady level of the drug in your body so the drug can work effectively.

You can take your dose of medication with or without food. You should swallow Lumakras tablets whole. Do not break, crush or chew the tablets.

If you have trouble swallowing Lumakras tablets whole, you can put your dose in 4 ounces (oz) of room-temperature water. Do not crush the tablets or mix them with any other liquid besides water. Stir the mixture until the tablets are in pieces. Then, drink the mixture within 2 hours of mixing it. Be sure not to chew any pieces of the tablet remaining in the water. Lastly, fill the glass with an additional 4 oz of water and drink that. This helps ensure that you have gotten your full dose of medication.

You can talk with your doctor or a pharmacist if you have questions about how to take Lumakras. You can also see the manufacturer’s website.

Accessible drug labels and containers

If you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Lumakras in an easy-open container. They also may recommend tools that can make it easier to open bottles.

If you miss a dose of Lumakras and it’s been 6 hours or less, take the missed dose as soon as you remember. However, if it’s been more than 6 hours since the missed dose, skip the missed dose and take your next dose at your regular time.

Never take two doses of Lumakras to try to make up for a missed dose.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

It’s important that you do not take more Lumakras than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose.

If you take more than the recommended amount of Lumakras

Call your doctor right away if you believe you’ve taken too much Lumakras. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug manufacturer. If your doctor recommends Lumakras for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.

As with any drug, never change your dosage of Lumakras without your doctor’s recommendation. If you have questions about the dosage of Lumakras that’s right for you, talk with your doctor.

Besides learning about dosage, you may want other information about Lumakras. These additional resources might be helpful to you:

  • More about Lumakras. For information about other aspects of Lumakras, refer to this article.
  • Details about lung cancer. For more articles about lung cancer, see our lung cancer hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.