Nexlizet (bempedoic acid and ezetimibe) is a brand-name drug that’s prescribed to lower LDL cholesterol in certain adults. Nexlizet comes as an oral tablet that’s typically taken once per day.
Nexlizet is approved by the Food and Drug Administration (FDA) to treat high cholesterol in adults with:
- heterozygous familial hypercholesterolemia (HeFH)
- atherosclerotic cardiovascular disease
Nexlizet contains two active drug ingredients: bempedoic acid and ezetimibe. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor. Ezetimibe is a cholesterol absorption inhibitor. Nexlizet is not available in a generic version.
Keep reading for specific information about the dosage of Nexlizet, including its strength and how to take the medication. For a comprehensive look at Nexlizet, see this article.
Note: This article describes typical dosages for Nexlizet provided by the drug’s manufacturer. When taking Nexlizet, always follow the dosage prescribed by your doctor.
The information below describes Nexlizet’s typical dosage and other details about the drug.
Nexlizet form
Nexlizet comes as an oral tablet that’s taken by mouth.
Nexlizet strength
Nexlizet comes in one strength. Each tablet contains 180 mg of bempedoic acid and 10 mg of ezetimibe.
Typical dosages
The following information describes dosages that are commonly used in adults. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
Dosage for reducing LDL cholesterol
Doctors may prescribe Nexlizet to help decrease LDL cholesterol. The drug is typically taken with other cholesterol-lowering drugs like statins.
If your doctor prescribes Nexlizet for your LDL cholesterol, your dose will likely be one tablet by mouth. Typically, you’ll take this once daily. This is the maximum dose of Nexlizet that’s recommended.
For more information about your specific dosage, talk with your doctor.
Long-term treatment
Nexlizet is meant to be taken as a long-term treatment. If you and your doctor determine that Nexlizet is safe and effective for you, you’ll likely take it long term.
Before you start taking Nexlizet, your doctor will discuss your treatment plan with you.
The price you’ll pay for Nexlizet can vary. Your cost may depend on your treatment plan, your insurance coverage (if any), and the pharmacy you use. To save money on your Nexlizet prescription, explore the coupon options below.
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Nexlizet comes as an oral tablet that you swallow whole. Do not divide, crush, chew, or place the tablet in water. You may take your dose with or without food.
If you’re also taking a medication called a bile acid sequestrant, be sure to take Nexlizet at least 2 hours before or 4 hours after the bile acid sequestrant. Examples of these drugs include:
- cholestyramine (Prevalite)
- colesevelam (Welchol)
- colestipol (Colestid)
It may be helpful to take Nexlizet around the same time of day. This helps maintain a steady level of the drug in your body so Nexlizet can work effectively.
If you have trouble swallowing tablets, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.
ACCESSIBLE DRUG LABELS AND CONTAINERSSome pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.
If you’re having trouble opening medication bottles, ask your pharmacist about putting Nexlizet in an easy-open container. They also may recommend tools that can make it easier to open bottles.
If you miss a dose of Nexlizet, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take your next scheduled dose. Do not take two doses to make up for the missed one. If you’re not sure whether you should take a missed dose or skip it, talk with your doctor or pharmacist.
To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.
It’s important that you don’t take more Nexlizet than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.
If you take more than the recommended amount of Nexlizet
Call your doctor right away if you believe you’ve taken too much Nexlizet. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.
Below are some frequently asked questions about Nexlizet.
Is the dosage of Nexlizet similar to the dosage of statin drugs?
Yes, the forms and how often you take each drug are similar. Nexlizet and statin drugs like atorvastatin (Lipitor) are both oral tablets that are taken once daily. In fact, usually, you’ll take Nexlizet along with a statin drug to manage high LDL cholesterol.
The dose in milligrams for each drug differs because they have different active ingredients. Your doctor will prescribe the drug and the dosage that’s right for you.
To learn more about how these drugs compare, talk with your doctor.
How long does it take for Nexlizet to start working?
Nexlizet starts to work after your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor your cholesterol through blood tests during your treatment to check whether the drug is working to treat your condition. They will check your cholesterol levels about 8–12 weeks after starting Nexlizet to see how well the medication is working for you.
Talk with your doctor if you have questions about what to expect with Nexlizet treatment.
The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Nexlizet for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.
As with any drug, never change your dosage of Nexlizet without your doctor’s recommendation. If you have questions about the dosage of Nexlizet that’s best for you, talk with your doctor.
Besides learning about dosage, you may want other information about Nexlizet. These additional articles might be helpful:
- More about Nexlizet: For information about other aspects of Nexlizet, refer to this article.
- Side effects: To learn about side effects of Nexlizet, see this article. You can also look at the Nexlizet prescribing information.
- Details about your condition: For details about high cholesterol, see our cardiovascular health hub.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.