Orencia (abatacept) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat the following conditions:

Orencia comes as a solution that’s given by subcutaneous injection or by IV infusion.

The active drug in Orencia is abatacept, which is a biologic. Orencia is classified as an immunomodulator. It’s not available in a biosimilar version.

For information about the dosage of Orencia, including its strengths and how to take the drug, keep reading. For a comprehensive look at Orencia, see this article.

This article describes typical dosages for Orencia provided by the drug’s manufacturer. When receiving Orencia, always follow the dosage prescribed by your doctor.

Keep reading to learn more about Orencia dosages, including the drug’s dosing frequency, IV dosing, and loading dose.

Orencia forms

Orencia comes as a solution in the following forms:

Note: Your doctor or pharmacist may abbreviate subcutaneous as “sq” on your prescription.

Orencia strengths

The table below details different Orencia strengths for each form of the Orencia:

Vial for IV infusionSyringe for subcutaneous injectionClickJect autoinjector for subcutaneous injection
250 milligrams (mg)50 mg per 0.4 milliliters (50 mg/0.4 ml)125 mg/ml
87.5 mg/0.7 ml
125 mg/ml

Typical dosages

The following information describes dosages that are commonly prescribed or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for psoriatic arthritis

For treating psoriatic arthritis (PsA), Orencia may be given as a subcutaneous injection, or as an IV infusion.

Subcutaneous injection dosage for PsA

For treating PsA by subcutaneous injection, the recommended Orencia dosage is 125 mg once per week.

IV infusion dosage for PsA

For treating PsA by IV infusion, you’ll first receive a loading dose of Orencia. A loading dose is a high dose given at the start of treatment to help the medication work faster.

The loading dose is given as three separate infusions at weeks 0, 2, and 4. After this, you’ll receive Orencia infusions once every 4 weeks.

Your doctor will determine your Orencia IV infusion dosage based on your body weight in kilograms (kg), as shown in the chart below. 1 kg is about 2.2 pounds (lb).

Body weightDoseNumber of vials needed
Fewer than 60 kg (fewer than 132 lb)500 mg2
60 kg to 100 kg (about 132 lb to 220 lb)750 mg3
More than 100 kg (more than 220 lb)1000 mg4

Dosage for rheumatoid arthritis

For treating rheumatoid arthritis (RA), Orencia may be given as a subcutaneous injection or as an IV infusion.

Subcutaneous injection dosage for RA

For treating RA by subcutaneous injection, the typical Orencia dosage is 125 mg. The dosing frequency for RA is once per week.

Before your first dose, your doctor may give you a single loading dose of Orencia as an IV infusion. Talk with your doctor about whether they’ll prescribe a loading dose for you. For more information, see the “Typical dosages” section above.

Note: Your doctor or pharmacist may abbreviate subcutaneous as “SQ” on your prescription.

IV infusion dosage for RA

For treating RA by IV infusion, you’ll first receive a loading dose of Orencia.

The loading dose is given as three separate doses at weeks 0, 2, and 4. After that, your dosing frequency will be once every four weeks.

Your doctor will determine your Orencia IV infusion dosage based on your body weight in kg, as shown in the chart below. 1 kg is about 2.2 lb.

Body weightDoseNumber of vials needed
Fewer than 60 kg (fewer than 132 lb)500 mg2
60 kg to 100 kg (about 132 lb to 220 lb)750 mg3
More than 100 kg (more than 220 lb)1000 mg4

Children’s dosage

Orencia is approved to treat polyarticular juvenile idiopathic arthritis (pJIA) in children ages 2 years and older. For this condition, it may be prescribed alone or in combination with the medication methotrexate (Trexall). Your child might receive Orencia as a subcutaneous injection or as an IV infusion, depending on their age.

Subcutaneous injection dosage for children

When given by subcutaneous injection in children ages 2 years and older, Orencia is given once per week. Your child’s dose will be determined based on their weight in kg, as shown in the table below.

Child’s body weightWeekly dose
10 kg to fewer than 25 kg50 mg
25 kg to fewer than 50 kg87.5 mg
50 kg or greater125 mg

IV infusion dosage for children

Orencia may be given as an IV infusion to treat pJIA in children ages 6 years and older. Children ages 2 years to fewer than 6 years old should receive Orencia by subcutaneous injection.

Your child’s dose will depend on their weight in kg, as follows:

  • In children who weigh fewer than 75 kg (about 165 lb): Orencia is given in a dose of 10 mg per kg. For example, a child weighing 30 kg (about 66 lb) will receive a 300 mg infusion.
  • In children weighing 75 kg (about 165 lb) or more: the adult dosing chart should be used, up to a maximum dose of 1,000 mg. For example, a child weighing 78 kg (about 178 lb) will receive a dose of 750 mg. See the adult dosing chart in the “IV infusion dosage for RA” section above.

Your child will receive Orencia infusions at weeks 0, 2, and 4. After this, your child will have an infusion every 4 weeks.

Long-term treatment

Orencia is meant to be a long-term treatment. If you and your doctor determine that Orencia is safe and effective for you, you’ll likely receive it long term.

The Orencia dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re prescribed Orencia to treat
  • the form of Orencia you’re prescribed
  • your age
  • your weight

Orencia may be given as either an IV infusion or as a subcutaneous injection. Be sure to follow instructions from your doctor or healthcare professional about how to take Orencia.

Orencia by IV infusion

If you’re receiving Orencia as an IV infusion, you’ll need to schedule infusion appointments at your doctor’s office, an infusion or healthcare clinic, or similar setting. A healthcare professional will insert a needle into your vein and connect it to a bag filled with liquid containing Orencia.

Orencia infusions usually last around 30 minutes. During this time, the liquid containing Orencia slowly drips into your vein.

Your doctor or another healthcare professional may monitor you for a few minutes at the end of your infusion. This is to make sure you don’t have any serious side effects from the infusion.

Orencia by subcutaneous injection

Your doctor may prescribe Orencia as a subcutaneous injection.

Your doctor or healthcare professional will give you your first injection of Orencia. Then they may show you how to give yourself your next injections at home.

Orencia injections may be given using either a prefilled syringe or a prefilled ClickJect autoinjector. You won’t have to measure out your Orencia dose with either form. Each syringe or autoinjector will contain the exact amount of Orencia that your doctor prescribes for each injection.

The Orencia website contains more information about self-injecting Orencia. You can also talk with your doctor or pharmacist if you have questions about giving yourself Orencia injections.

If you miss an appointment for an Orencia infusion or injection, contact your doctor or healthcare professional as soon as possible. They can help reschedule your appointment for as soon as they have availability. It’s very important to get your infusion as soon as possible, because symptoms of your condition may come back if you go too long without an Orencia dose.

If you give yourself Orencia injections at home and you miss a dose, try to give yourself the missed dose as soon as you remember. You should then call your doctor, as they can help set up a new dosing schedule for you. Do not give yourself more than one Orencia dose at once.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

It’s important that you do not give yourself more Orencia than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose.

If you give yourself more than the recommended amount of Orencia

Call your doctor right away if you believe you’ve given yourself too much of Orencia. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Orencia for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Orencia without your doctor’s recommendation. If you have questions about the dosage that’s right for you, talk with your doctor.

Besides learning about dosage, you may want other information about Orencia. These additional articles might be helpful to you:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.