Trodelvy (sacituzumab govitecan-hziy) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat certain types of cancer in adults. It’s FDA approved to treat:
- Urothelial (bladder) cancer* that is metastatic† or advanced.
- Triple-negative breast cancer that is advanced or metastatic and unresectable (can’t be treated with surgery).
Trodelvy is approved to treat these conditions when other cancer therapy has not worked.
Trodelvy contains the active ingredient sacituzumab govitecan-hziy. It’s considered an antibody-drug conjugate. This means that the drug is an immune system protein combined with chemotherapy.
Trodelvy comes as powder in vials. A healthcare professional will mix the powder with liquid to make a solution. They will give you Trodelvy as an IV infusion.
* Trodelvy has received accelerated approval for this use. This means that the FDA has approved Trodelvy to treat urothelial cancer based on early study data. The FDA may grant full approval at a later date after there have been more clinical trials.
† “Metastatic” means the cancer has spread to other parts of your body.
The following chart summarizes Trodelvy’s form, strength, and dosage. Your doctor will determine the dosage that’s best for you.
|Powder for solution to be given as an IV infusion||180 milligrams (mg)||10 mg/kilogram once per week on days 1 and 8 of a 21-day treatment cycle|
For information about the dosage of Trodelvy, including its strength and how to use the drug, keep reading. For a comprehensive look at Trodelvy, see this article.
This article describes typical dosages of Trodelvy provided by the drug’s manufacturer. But your doctor will prescribe the Trodelvy dosage that is right for you.
This section describes the typical dosage of Trodelvy.
Trodelvy comes as a powder in a vial. Your healthcare professional will add sodium chloride to the powder to turn it into a solution. They will give you Trodelvy as an IV infusion.
Trodelvy is available in one strength: 180 milligrams (mg) per vial.
The following information describes the dosage that is commonly used or recommended. Your doctor will determine the best dosage to fit your needs.
Trodelvy dosage for all uses
Your Trodelvy dosage will depend on your weight. Your healthcare professional will take your weight before each dose.
The recommended dose of Trodelvy is 10 mg/kilogram (kg) of body weight. For example, if you weigh 70 kg (about 154 pounds), your dose will likely be 700 mg.
The dosing schedule of Trodelvy is once per week on days 1 and 8 of a 21-day treatment cycle. You will not receive Trodelvy on any other day during the 21-day cycle. This means you will not receive Trodelvy on week 3 of treatment. This cycle may be repeated until Trodelvy is no longer treating your condition or you experience certain side effects.
There is no loading dose of Trodelvy. However, you will receive other medications before your Trodelvy doses to help prevent infusion reactions, nausea, and vomiting.
Trodelvy is meant to be used as a long-term treatment. If you and your doctor determine that Trodelvy is safe and effective for you, you’ll likely use it long term.
The Trodelvy dosage that your doctor prescribes will depend on several factors. These include:
- your weight
- how well you tolerate Trodelvy
- how well your cancer responds to Trodelvy
Other medical conditions you have can also affect your Trodelvy dosage.
Your doctor may temporarily stop your Trodelvy treatment if you experience severe diarrhea* or neutropenia.* You may be able to continue the treatment once your side effects resolve. However, your doctor will likely decrease your Trodelvy dosage.
Your doctor may slow your infusion time if you experience an infusion reaction. If this reaction is life-threatening, your doctor will stop the Trodelvy infusion and discontinue the treatment.
Trodelvy is given as an IV infusion by a healthcare professional in an infusion center, hospital, or your doctor’s office.
The first infusion will take 3 hours. If you tolerate this, your next infusions can be given over 1 to 2 hours.
Your doctor or another healthcare professional will monitor you during the infusion and for 30 minutes after. This is to see if you have an infusion reaction.
If you miss an appointment, call your doctor or infusion center right away to reschedule. It’s important to not miss your appointments. If you miss a dose of Trodelvy, there will be less medication in your body to treat your condition.
To help make sure that you don’t miss an appointment, try using a medication reminder. This can include setting an alarm or putting the appointment in your calendar. You could also download a reminder app on your phone.
The dosage in this article is the typical dosage provided by the drug’s manufacturer. If your doctor recommends Trodelvy for you, they will prescribe the dosage that’s right for you.
If you have questions about the dosage of Trodelvy that’s right for you, talk with your doctor.
Besides learning about the dosage, you may want other information about Trodelvy. These additional articles might be helpful to you:
- More about Trodelvy. For information about other aspects of Trodelvy, refer to this article.
- Details about your condition. For details about cancer, visit our cancer hub. If you’d like to learn more about breast cancer, see our breast cancer hub and list of breast cancer articles.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.