Vyepti (eptinezumab-jjmr) is a brand-name IV infusion that’s prescribed for preventing migraine episodes in adults. The cost of the drug with and without insurance can depend on several factors, such as whether Vyepti has a savings program.

As with all medications, the cost of Vyepti can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • the cost of the visit to your healthcare professional to receive doses of Vyepti
  • whether Vyepti has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Vyepti will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Vyepti prescription, explore these Optum Perks coupons.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

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Vyepti contains the active ingredient eptinezumab-jjmr, and it’s available only as a brand-name biologic drug. It doesn’t come in a biosimilar version. A biosimilar medication is a drug that’s similar to a brand-name biologic drug (the parent drug). Also, biosimilars tend to cost less than brand-name medications.

WHY ARE COSTS DIFFERENT FOR BIOLOGIC DRUGS VS. BIOSIMILAR DRUGS?

Biologic drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a biologic drug can sell it for up to 12 years. When the biologic drug’s patent expires, multiple manufacturers can create biosimilar versions. This marketplace competition may lead to lower costs for biosimilars. Also, because biosimilars are very similar to biologic drugs, they don’t require the same costly testing.

If you need financial support to pay for Vyepti, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called the Vyepti Connect Copay Assistance Program is available for Vyepti. For more information and to find out if you’re eligible for support, call 833-489-3784 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Vyepti.

What is the cost of Vyepti without insurance?

The price you’ll pay for Vyepti if you don’t have insurance can vary based on several factors. But typically, the cost is higher for those without insurance.

There are other factors that could affect what you pay for this drug. These include:

  • whether you apply and qualify for any available savings programs
  • your dosage
  • the pharmacy you use

To learn the exact cost you’d pay for this medication without insurance, ask your doctor or pharmacist. You may also want to contact several pharmacies to compare their prices for Vyepti.

Check out Optum Perks* for estimates of Vyepti’s price when using coupons from the site. (Optum Perks coupons cannot be used with insurance benefits or copays.)

* Optum Perks is a sister site of Medical News Today.

Is Vyepti covered by Medicare?

It may be. You can call your Medicare plan provider to learn whether your particular plan covers the cost of this drug. There are many types of Medicare plans, so your coverage and what you pay for prescriptions will be based on your particular plan’s benefits.

The total price you pay for Vyepti may also depend on the cost to receive infusions at your doctor’s office or clinic. You may also need to obtain prior authorization before your plan will cover the cost of this medication.

Your doctor may also be able to provide information about your cost for Vyepti if you have Medicare.

Below is information you may want to consider if you have insurance and receive Vyepti.

Prior authorization: If you have insurance, your insurance company may require prior authorization before it covers Vyepti. This means the company and your doctor will discuss Vyepti in regard to your treatment. The insurance company will then determine whether the medication is covered.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Vyepti requires prior authorization.

Type of insurance coverage: Vyepti is given by your doctor or another healthcare professional. If you have insurance, the price of your Vyepti doses may be billed through your medical coverage instead of the prescription drug portion of your insurance plan. This depends on your specific insurance plan and where you receive your Vyepti doses, such as at your doctor’s office, an infusion clinic, or a hospital.

If you have questions about this process, contact your doctor or your insurance provider.

Now that you’ve learned about cost and Vyepti, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Vyepti. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for Vyepti.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.