Although participants in clinical trials of Zepbound did not report depression as a side effect, the drug does carry a warning for suicidal thoughts or behaviors. These more serious side effects were reported in clinical trials of other drugs that are pharmacologically similar to Zepbound.
Depression can manifest with a range of combined physical and psychological symptoms, including:
- sadness or hopelessness
- constant difficulty concentrating or making decisions
- fatigue or low energy
- loss of interest in hobbies and activities that you used to enjoy
- persistent feelings of guilt or worthlessness
- agitation
- difficulty sleeping
- unwanted changes in appetite and body weight
- loss of sexual desire
- thoughts of suicide
- suicide attempts
A healthcare professional typically diagnoses depression when five or more of these symptoms are present for at least 2 consecutive weeks.
Depression responds well to treatment. Talk therapy can help relieve your symptoms, and medications may also help in some cases.
If you’re experiencing symptoms of depression after taking Zepbound, help is available, and you’re not alone. Only a healthcare professional can provide an accurate diagnosis and a management plan tailored to your needs.
Help is out there
If you or someone you know is in crisis and considering suicide or self-harm, please seek support:
- Call or text the 988 Lifeline at 988 or chat at 988lifeline.org. Caring counselors are available to listen and provide free and confidential support 24/7.
- Text HOME to the Crisis Text Line at 741741 to connect with a volunteer crisis counselor for free and confidential support 24/7.
- Not in the United States? Find a helpline in your country with Befrienders Worldwide.
- Call your local emergency services number if you feel safe to do so.
The prescribing information for Zepbound does not report any long-term side effects of the drug.
Long-term side effects include those that may start at any time you’re taking a drug, even if you’ve taken it for a long time. It also includes side effects that may not go away, even after you stop taking the drug.
More research is needed to understand the long-term mental health impact of taking Zepbound. But if you’re experiencing low mood or any other potential symptom of depression, it’s important to speak with a doctor. They can explore alternative management options or possible related causes.
It’s important not to discontinue your medications without a doctor’s supervision and guidance. If you have more questions about how long Zepbound’s side effects may last, talk with your doctor or pharmacist.
Disclaimer: While Medical News Today strives for factual, comprehensive, and current drug information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses. Learn more about our approach to content integrity.