Altering Food and Light Schedules Affects Cancer Genes in Mice
The circadian clock regulates the approximate 24-hour cycles of many animals, including mammals. It has been reported that tumors grow faster in animals with a disrupted circadian clock--which happens, for example, in chronic jet lag--but the molecular mechanism is unclear.
Francis L?vi, M.D., Ph.D., of the French National Institute of Health and Medical Research (INSERM) and University Paris XI at Paul Brousse Hospital in Villejuif, France, and colleagues compared the expression patterns of circadian clock and cell cycle genes in the livers and tumors of mice synchronized by normal light and dark schedules (normal circadian clock) or with schedules designed to simulate chronic jet lag in humans (disrupted circadian clock). They found that meal timing reversed the disrupted circadian clock gene expression patterns and slowed tumor growth in chronic jet lagged mice. The authors conclude that the altered light/dark or feeding schedules modified the expression of circadian clock genes and genes involved in carcinogenesis and tumor progression.
Contact: Monique L?vi, French National Institute of Health and Medical Research, 33 1 45 59 38 55, email@example.com
Also in the April 6 JNCI:
? Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk
? Antioxidant May Have Adverse Effects in Head and Neck Cancer Patients:
? Studies Examine Menopausal Hormone Therapy and Risk of Breast Cancer Recurrence:
? Study Examines Effectiveness of Anti-Anemia Drug in Treatment of Cancer Patients:
Note: The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jncicancerspectrum.oupjournals.org.
Contact: Sarah L. Zielinski
Journal of the National Cancer Institute
There are no references listed for this article.
Please use one of the following formats to cite this article in your essay, paper or report:
Zielinski, Sarah L.. "Altering Food and Light Schedules Affects Cancer Genes in Mice." Medical News Today. MediLexicon, Intl., 6 Apr. 2005. Web.
26 Sep. 2016. <http://www.medicalnewstoday.com/releases/22370.php>
Zielinski, S. (2005, April 6). "Altering Food and Light Schedules Affects Cancer Genes in Mice." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.