Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
HIV can infect transplanted kidneys in HIV-positive recipients even in the absence of detectable virus in the blood, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The study's investigators also developed a simple urine test to diagnose such infections.
HIV is a common cause of kidney failure, and because of this, approximately 900 HIV-infected patients start dialysis each year in the United States. Kidney transplantation has recently become a therapeutic option for these patients, and the survival rate of HIV-infected transplant recipients with undetectable HIV in the blood is similar to that of non-HIV-infected transplant recipients. For unknown reasons, however, organ rejection is more common in HIV-infected transplant recipients.
To investigate this issue, Guillaume Canaud, MD, PhD (Necker Hospital, in Paris, France) and his colleagues assessed all 19 of HIV-positive patients in their center who received kidney transplants between June 1, 2006, and October 31, 2011. Genetic analyses demonstrated that HIV infection occurred in 68% of the HIV-positive recipients' new organs even in the absence of any detectable HIV in their blood.
Biopsy experiments revealed two different forms of infection. In the first case, podocyte cells - which constitute the barrier through which blood is filtered in the kidneys - are the main target of HIV, and infection is associated with certain clinical signs of kidney dysfunction. In the second case, HIV infects tubular cells within the kidney, with fewer clinical manifestations.
The researchers also developed a new and simple urine test to detect HIV infection in the kidneys, which could be a promising non-invasive method for diagnosing problems in HIV-positive transplant recipients.
"This study is going to change the way of thinking of nephrologists and will certainly modify the approach of kidney transplantation in HIV patients, giving new hope to patients," said Dr. Canaud.
According to an accompanying editorial by Peter Stock, MD (University of California, San Francisco), the noninvasive urine test that detects early HIV-1 infection will help clinicians identify donor and recipient factors associated with recurrent HIV kidney disease. "It is less clear what intervention may control the reinfection, although identification of donor and/or recipient factors associated with early reinfection may provide some clues," he wrote.
Study co-authors include Nathalie Dejucq-Rainsford PhD, Véronique Avettand-Fenoël MD, PhD, Jean-Paul Viard, MD, Dany Anglicheau MD, PhD, Frank Bienaimé MD, PhD, Mordi Muorah, MD, Louise Galmiche MD, PhD, Olivier Gribouval, Laure-Helene Noël, MD, Anne-Pascale Satie, Frank Martinez, MD, Rebecca Sberro-Soussan, MD, Anne Scemla, MD, Marie-Claire Gubler, MD, Gérard Friedlander MD, PhD, Corinne Antignac, MD, PhD, Marc-Olivier Timsit MD, PhD, Andrea Onetti Muda, MD, Fabiola Terzi MD, PhD, Christine Rouzioux MD, PhD, and Christophe Legendre, MD.
Disclosures: The authors reported no financial disclosures.
The article, entitled "The Kidney as a Reservoir for HIV-1 After Renal Transplantation," appeared online on December 5, 2013, doi: 10.1681/ASN.2013050564.
The editorial, entitled "Kidney Infection with HIV-1 Following Kidney Transplantation," appeared online on December 5, 2013, doi: 10.1681/ASN.2013101112.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our HIV / AIDS category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
American Society of Nephrology. "Why HIV is a common cause of kidney failure." Medical News Today. MediLexicon, Intl., 10 Dec. 2013. Web.
9 Mar. 2014. <http://www.medicalnewstoday.com/releases/269838>
American Society of Nephrology. (2013, December 10). "Why HIV is a common cause of kidney failure." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/269838.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.