This is the first case of a “functional cure” in an HIV-positive infant
“Prompt antiviral therapy in newborns that begins within days of exposure may help infants clear the virus and achieve long-term remission without lifelong treatment by preventing such viral hideouts from forming in the first place.”
The infant, who is now “functionally cured” – has achieved and maintained long-term viral remission without lifelong treatment and standard clinical tests found no evidence of HIV replication in the blood.
What is the difference between a functional cure and a sterilizing cure?
However, according to all the tests, the child was HIV free
this latest infant’s case provides compelling evidence to start proof-of-principle studies in all high-risk newborns
This occurred with Timothy Brown, a middle-aged man who was HIV-positive and also had leukemiabone marrow
“Complete viral eradication on a large scale is our long-term goal but, for now, remains out of reach, and our best chance may come from aggressive, timely and precisely targeted use of antiviral therapies in high-risk newborns as a way to achieve functional cure.”
New York Times
The primary goal for babies, the researchers stressed, continues to be the prevention of mother-to-child transmission of HIV