A prostate biopsy involves taking a tissue sample from a person’s prostate to check for signs of cancer. The procedure is often uncomfortable, not painful, and a person will recover within days.
Prostate cancer is a common form of cancer in natal males. It affects the prostate gland, a small part of the reproductive system below the bladder but in front of the rectum. The prostate produces a fluid that makes up the majority part of semen.
This article explains the prostate biopsy procedure, including what to expect before and afterward.
This type of cancer is highly treatable, especially if a person receives a diagnosis when the disease is in its early stages. Statistics show that
However, prostate cancer often produces no symptoms in the early stages. For this reason, most experts recommend screening after
There are different ways in which a doctor may perform a prostate biopsy.
Transperineal skin biopsy
A transperineal biopsy is one type of biopsy procedure. Doctors typically perform it under CT scan or MRI guidance. Following the administration of local anesthesia, a doctor will make a small skin incision between the anus and the scrotum. To extract tissue samples, they will insert the needle through the incision and direct the needle directly into the prostate.
Transrectal prostate biopsy
Alternatively, doctors may perform a transrectal prostate biopsy. During this form of prostate biopsy, a doctor will use local anesthesia to numb the area. They will then use an ultrasound probe to guide a needle to take several small prostate tissue samples
The doctor will insert the probe into the rectum to obtain an image of the prostate gland. The prostate is on one side of the rectal wall. Using the image for guidance, the doctor will use the needle to remove 6–14 core samples, depending on the type of biopsy. They will usually take some samples from each side of the prostate.
A spring-loaded tool punches the needle into the prostate gland. Each sample comprises a minute cylindrical core of cells. The action is very quick, and the anesthesia means that it is not usually painful. Typically, the entire procedure takes less than 10 minutes.
The doctor may use an ultrasound or MRI scan to guide the procedure. Ultrasound guided biopsies usually take up to 45 minutes to complete. An MRI guided biopsy can provide more detailed images. These biopsies may take 30–90 minutes and involve contrast dye. Healthcare staff will monitor the individual for up to an hour afterward.
Will it hurt?
Although it may be uncomfortable, the procedure is not usually painful. A doctor will most likely administer an anesthetic injection into the rectum area before the procedure to numb any pain. The injection may cause some discomfort, as might the probe. During the biopsy, the individual should not feel any pain due to the anesthesia, but they might feel a pinch as the needle enters the tissue.
To reduce the risk of infection, doctors usually provide the individual with antibiotics to take before the biopsy and for up to 2 days afterward.
A person can minimize the recovery time following a prostate biopsy by:
A biopsy can sometimes cause side effects. These may include:
- frequently needing to urinate
- a burning sensation when urinating
- blood in the urine
- blood in the semen
- blood in the stool
- urinary tract or prostate infection
- urinary retention
Before a biopsy procedure, the doctor will ask the person about their overall health. They will need to know about any medications and supplements the individual takes and any allergies or other medical conditions.
The doctor may ask the person to prepare by:
- stopping the use of blood thinners, such as aspirin or warfarin, 7–10 days before the biopsy
- starting to take antibiotic pills 1–2 days before the biopsy to reduce the risk of infection
- eating only a light meal on the day of the examination
- using an enema at home before attending the biopsy
- arranging a lift home from the procedure if they will require sedation
It is also useful to ask questions and find out as much as possible beforehand about the biopsy and what the results might mean. Having this information can help people feel more confident and in control of the process.
The doctor may prescribe an antibiotic to reduce the risk of an infection occurring after the biopsy. After the procedure, a person may experience:
- some light bleeding from the rectum
- some drowsiness, if the procedure involves sedation or anesthesia
- some discomfort for 1–2 days
- blood in the feces, urine, or sperm
If any side effects are significant or worsen rather than improving, the person should contact their doctor.
Some discomfort is likely during the recovery time, but sometimes, more severe complications can arise. If the following symptoms occur, the person should immediately contact their doctor:
- a rapid heart rate
- fever and chills
- shortness of breath
- pain and discomfort
- clammy or sweaty skin
The authors of a 2019 review conclude that an MRI may be more likely to find a mass within the prostate than a biopsy but note that errors still occur with this method. While a prostate biopsy can determine for certain whether prostate cancer is present, the possibility of complications means that it is preferable to avoid
As such, evidence suggests that combining the techniques may be the most effective strategy to identify clinically significant cancers without unnecessary testing.
Other tests for prostate cancer include a DRE and the PSA test. A doctor will usually carry out these tests before recommending a biopsy. However, only a biopsy can confirm the presence of cancer.
A biopsy will show whether the prostate cells are normal or cancerous. If the cells are normal, the doctor may recommend no further action. If cancer is present, the biopsy can also reveal the extent to which the cells have changed and how quickly the disease is likely to progress.
The pathologist who examines the sample will give the cells a grade known as the
A biopsy can also show how far cancer has spread. For example, if all the biopsy samples contain cancerous cells, cancer will likely be present throughout the prostate gland. If only three out of 12 samples are cancerous, cancer is less widespread.
Precancerous cells and PIN
Sometimes, the results will show that precancerous cells, or prostatic intraepithelial neoplasia (PIN), are present.
Based on microscopic examination of the biopsy specimens, doctors characterize PIN as low grade (benign) or high grade (potentially worrisome).
If the findings of PIN are low grade, the doctor will not consider this a matter of concern. Many natal males have low grade PIN. However, if the PIN is high grade, there is a chance that cancer may develop. In these cases, a doctor may suggest further tests.
If a person already has prostate cancer, the grade of the PIN
Carcinoma in situ refers to noninvasive cells that have the potential to become cancerous.
Although prostate biopsies are a useful tool, evidence suggests that they can miss
The outlook for a person undergoing a prostate biopsy depends on the biopsy results and other tests. If the results show that cancer is only present in or around the prostate gland, there is an
Factors that affect the outlook for a person with prostate cancer include:
- their age and overall health
- the type of cancer
- how far cancer has spread
Prostate cancer is a common cancer among natal males. Individuals who know that they have an increased risk of prostate cancer should start speaking with a doctor about screening from the age of 40 years. Those with an average risk should undergo screening beinning age of 50 years.