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Breast cancer (BRCA) genes influence the risk of someone developing breast, ovarian, and other types of cancer. Several at-home tests are available for identifying one or more of these genes.
The presence of BRCA genes, such as BRCA1 and BRCA2, can increase the risk of various types of cancer. Genetic testing is one way of identifying genetic mutations with links to certain cancers, such as breast cancer.
Healthcare practitioners can administer genetic tests to identify these mutations. In addition, at-home BRCA gene testing kits have become available on the market.
- Best overall: Color Genetic Test for Common Cancers
- Best for accuracy: Ultimate Genome Sequencing Breast Cancer Package
- Best test without physician referral: 23andMe Personal Genome Service Genetic Health Risk Report for BRCA1/BRCA2
- Best medical grade testing: Invitae Cancer Screen
- Best customizable test: tellmeGen DNA Test Advanced
- Best comprehensive information: Nebula Genomics Deep Whole Genome Sequencing
All human genes contain DNA that carries the code for an individual’s distinctive traits, such as hair or eye color. A person receives two copies of each gene — one from each biological parent. This means that an individual inherits a BRCA1 and BRCA2 gene from each biological parent, leaving them with two of each gene.
However, those who receive damaged BRCA genes are more at risk of developing several types of cancer. If a person inherited a harmful variant of the BRCA1 or BRCA2 gene, they would have inherited a normal copy of that gene from the other parent. However, during their lifetime, the normal copy can become lost or changed in some cells in the body. Individuals with these mutations have
Additionally, other less common genes contribute to breast cancer risk.
Members of families with a strong history of breast or ovarian cancer are most likely to have BRCA1 or BRCA2 mutations. These individuals are the best candidates for genetic testing, which detects mutations in the BRCA genes.
Only about 0.2% of the United States population has BRCA gene mutations that increase cancer risk. So, BRCA genetic testing is not necessary for most people.
However, those at risk of having BRCA gene mutations with
- the number of relatives with cancer
- the specific relation of those relatives
- particular types of cancer
- the ages at the time of diagnosis
The healthcare professional or counselor may also discuss the different types of genetic tests and their advantages and disadvantages. In addition, they may explain the meaning of various genetic testing results.
There are more than 1,000 BRCA mutations. Currently, genetic tests only screen for the most common mutations, and a negative test result for common mutations does not rule out an increased risk of breast cancer.
Additionally, some screenings use a
- Positive for specific mutation: This result can help those with an existing breast cancer diagnosis choose between treatment options. It can also assist people without a current diagnosis in taking steps to reduce their cancer risk. The degree of increased risk depends on the specific mutation.
- Positive for variant of unknown significance: This means a genetic mutation is present but is unknown to increase cancer risk.
- Negative: This means the test detected no genetic mutations that could increase the risk of cancer. However, someone can receive this result and still develop the disease.
- Inconclusive: This means the test has failed to conclude whether a gene mutation exists or not.
The NCI also states that 39–44% of women with BRCA1 mutations and 11–17% of those with BRCA2 mutations develop ovarian cancer. In comparison, just 1.2% of women develop ovarian cancer in the general population.
More than 1,000 BRCA mutations exist, but many at-home BRCA mutation test kits can only identify a few of the most common ones.
Other kits include full-panel tests, which are unreliable and lack approval from the
It is important to note that home BRCA gene tests should not replace a consultation with a doctor or other healthcare professional. Those who use these home testing kits should consider speaking with a genetic counselor.
The advantages of at-home BRCA gene test kits are that they are often convenient and, with prices ranging between $200 and $300, can often be less expensive than similar tests from healthcare clinics.
The disadvantages include:
- testing limitations, as the kits only check for three mutations
- positive results that may be incorrect
- a lack of direct genetic counseling
Medical News Today’s methodology
MNT chooses at-home tests that meet the following criteria where possible:
- Laboratories: Where possible, MNT will select companies that process test samples in
Clinical Laboratory Improvement Amendments-certifiedlabs.
- Budget: MNT chooses at-home tests suitable for a wide range of budgets.
- Privacy: MNT includes companies that offer robust and transparent privacy measures, such as data protection and discreet packaging.
- Test result speed: MNT selects companies that inform customers when they will receive their test results and whether they will receive them via email, app, or phone.
- Further support: MNT will indicate whether a company offers further support, such as a follow-up phone consultation with a doctor to discuss test results.
Please note that the writer of this article has not tried these products. All information presented is purely research-based.
This company requires the name and contact information of the user’s doctor, who must approve their eligibility for the test. Alternatively, the service can instruct a healthcare professional to review the eligibility of anyone without a doctor.
The test requires a saliva sample and takes around 3–4 weeks to process. The service can also connect people to genetic counselors and provide follow-up reports.
Customer reviews state the test is “easy to understand and guides you through the process in an approachable, calm way.”
The cost for this test is $250.
Best for accuracy
This company provides clinical-grade sequencing and ensures the confidentiality of results. The service includes a 1-month Silver membership that provides two additional DNA reports.
The test involves a saliva test sample and takes around 8 weeks for results. And while the company offers comparison data, it does not provide genetic counseling.
Customer reviews state that it is “the most accurate DNA test I took.”
The cost for this test is $394.
Best test without a physician referral
23andMe does not require a doctor to order this test, which detects three out of over 1,000 BRCA mutations. The tests are FDA-approved and come with a guarantee of data privacy.
23andMe collects a person’s saliva samples and takes around 3–4 weeks to return results. The service provides this information via an app but does not provide genetic counseling or follow-up reports.
Customer reviews state that it offers “excellent for real, actionable health information.”
The cost for this test is $99, plus $9.99 per month for an optional membership.
Best medical grade testing
Invitae provides medical-grade genetic testing. Its tests feature an interactive, educational portal to help people understand their results. The service also offers complete data privacy, but all tests require approval by a doctor.
The tests require saliva samples and take 10–21 days to return results. The company also provides access to educational materials and genetic counseling at no extra cost.
However, customer reviews on the Better Business Bureau highlight that while the company claims insurance companies will reimburse testing costs, they fail to follow through.
The cost for this test is $250.
Best customizable test
Using a person’s saliva sample, this company offers information on 440 genetic traits with links to health and well-being. The service takes around 4–6 weeks to return results and offers additional genetic counseling.
Customer reviews state that they provide an “amazing, secure, customizable DNA test!”
The cost for this test is $99.
Best comprehensive information
This company decodes 100% of a person’s DNA and provides quality results ready for interpretation by a doctor or genetic counselor. The service also guarantees the privacy of personal information.
The test either uses a cheek swab or saliva sample, with results available in around 12–14 weeks.
Customer reviews state that “no [other company] gets even close to the amount of information Nebula gives you.”
The cost for this test is $299, plus a subscription cost of $20 per month.
The following are common questions and answers about BRCA testing.
Is it worth testing for the BRCA gene?
People with a strong family history of breast or ovarian cancer would benefit from gene testing. However, they should be aware of the strengths and limitations of these screening techniques.
What is the difference between BRCA1 and BRCA2?
Mutations in each gene can increase the risk of different cancers.
What does it mean if a person has the BRCA gene?
This means that the individual is likely to have a mutation in either the BRCA1 or BRCA2 gene, putting them at an increased risk of developing breast cancer.
Mutations in the BRCA1 and BRCA2 genes can elevate a person’s risk of developing breast, ovarian, and other types of cancers. Genetic testing can identify BCRA gene mutations.
These test results could guide individuals in taking additional measures to help prevent the development of disease or assist doctors in choosing cancer treatments. And while home BRCA gene tests are now available on the market, they come with limitations.
Anyone who might have a BRCA gene mutation should discuss genetic testing with their doctor or genetic counselor.