Cyltezo (adalimumab-adbm) is a brand-name drug prescribed for several inflammatory conditions. Cyltezo comes as a liquid solution given by subcutaneous injection. It’s available as a single-dose prefilled pen and prefilled syringe.
Cyltezo is approved by the Food and Drug Administration (FDA) to treat:
- rheumatoid arthritis in adults
- psoriatic arthritis in adults
- ankylosing spondylitis (a form of arthritis that affects the spine) in adults
- juvenile idiopathic arthritis in children ages 2 years and older
- Crohn’s disease in adults and children ages 6 years and older
- ulcerative colitis in adults
- plaque psoriasis in adults
- hidradenitis suppurativa (a skin condition that causes painful cysts) in adults
- certain types of uveitis in adults
Cyltezo is a biologic drug and belongs to a drug class called tumor necrosis factor blockers. Cyltezo is a biosimilar of the brand-name drug Humira.
Keep reading for specific information about the dosage of Cyltezo, including its strengths and how it’s given. For a comprehensive look at Cyltezo, including details about its uses, see this article.
Note: This article describes typical dosages for Cyltezo provided by the drug’s manufacturer. During Cyltezo treatment, always follow the dosage your doctor prescribes.
The information below describes Cyltezo’s recommended dosages and other details about the drug.
Cyltezo forms
Cyltezo comes as a liquid solution in a single-dose prefilled pen and a single-dose prefilled syringe. It’s given as a subcutaneous injection.
Your doctor will prescribe the pen or syringe form of Cyltezo. They’ll show you how to self-inject the medication at home. To learn more, see the “How Cyltezo is given” section below.
Cyltezo strengths
Cyltezo prefilled pen comes in one strength: 40 milligrams per 0.8 milliliters of solution (40 mg/0.8 mL)
Cyltezo prefilled syringe comes in three strengths:
- 40 mg/0.8 mL
- 20 mg/0.4 mL
- 10 mg/0.2 mL
Typical dosages
Your doctor will typically start by prescribing you the initial recommended dosage for your condition. Depending on the condition, your doctor may prescribe a higher dose to start. This is known as a loading dose. It helps the medication begin working right away. The starting dosage schedule varies depending on the condition you’re taking the drug to treat.
The following information describes dosages that are commonly prescribed or recommended in adults. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
| Condition | Starting dosage | Maintenance dosage |
| rheumatoid arthritis | • 40 mg every other week, if you also take methotrexate or • 40 mg every week or 80 mg every other week, without methotrexate | same as your starting dosage |
| psoriatic arthritis | 40 mg every other week | same as your starting dosage |
| ankylosing spondylitis | 40 mg every other week | same as your starting dosage |
| Crohn’s disease | Day 1: 160 mg once* Day 15: 80 mg once | starting on Day 29: 40 mg every other week |
| ulcerative colitis | Day 1: 160 mg once* Day 15: 80 mg once | starting on Day 29: 40 mg every other week |
| plaque psoriasis | Day 1: 80 mg once | starting on Day 8: 40 mg every other week |
| hidradenitis suppurativa | Day 1: 160 mg once* Day 15: 80 mg once | starting on Day 29: 40 mg every week or 80 mg every other week |
| uveitis | Day 1: 80 mg once | starting on Day 8: 40 mg every other week |
* Your doctor may recommend giving the full 160-mg dose on treatment day 1 or dividing it over days 1 and 2. In this case, you would give 80 mg on day 1 and 80 mg on day 2.
Note: To learn more about the conditions Cyltezo is approved to treat, see the “Cyltezo uses” section in this article.
Children’s dosage
Cyltezo is prescribed for children ages 2 years and older with juvenile idiopathic arthritis (JIA). It’s also prescribed for children ages 6 years and older with Crohn’s disease.
Cyltezo’s dosage for children is based on body weight in kilograms (kg). For reference, 1 kg is about 2.2 pounds (lb). Your child’s doctor will determine the right dosage for your child based on their body weight.
Dosage for juvenile idiopathic arthritis
The table below shows the recommended weight-based dosage for JIA in children:
| Body weight (kg) | Body weight (lb) | Recommended dosage |
| 10 kg to less than 15 kg | about 22 lb to less than 33 lb | 10 mg every other week |
| 15 kg to less than 30 kg | about 33 lb to less than 66 lb | 20 mg every other week |
| 30 kg or more | about 66 lb or more | 40 mg every other week |
Dosage for Crohn’s disease
For Crohn’s disease, your child’s doctor will prescribe a loading dose. This is a higher dose at the start of treatment. It helps the medication begin working right away. The table below shows the recommended weight-based dosage for Crohn’s disease in children:
| Body weight (kg) | Body weight (lb) | Starting dosage | Maintenance dosage |
| 17 kg to less than 40 kg | about 37 lb to less than 88 lb | Day 1: 80 mg once Day 15: 40 mg once | starting on Day 29: 20 mg every other week |
| 40 kg or more | about 88 lb or more | Day 1: 160 mg once Day 15: 80 mg once | starting on Day 29: 40 mg every other week |
Long-term treatment
Cyltezo is meant to be a long-term treatment. If you and your doctor determine that Cyltezo is safe and effective for you, you’ll likely take it long term.
Talk with your doctor if you have questions about your Cyltezo treatment plan.
The Cyltezo dosage your doctor prescribes will depend on several factors. These include:
- the type and severity of the condition you’re taking Cyltezo to treat
- your age
- body weight in children
If you have questions about your Cyltezo dosage, talk with your doctor.
Cyltezo comes as a solution for subcutaneous injection. You’ll inject your doses at home using Cyltezo’s prefilled pen or syringe. Your doctor will prescribe the form that’s right for you. They’ll show you the proper injection technique when you’re first prescribed the medication.
Cyltezo is injected around your thigh or abdomen (at least 2 inches [in] away from your belly button). Be sure to choose a different spot for each dose. This will reduce your risk of injection-related side effects, such as bleeding or pain at the injection site.
To learn more about injecting Cyltezo, refer to the drug manufacturer’s instructions for use or call 800-542-6257.
Note: If you have difficulty self-injecting Cyltezo or other concerns about your treatment, talk with your doctor. They may recommend that a healthcare professional or caregiver administer Cyltezo to you.
ACCESSIBLE DRUG LABELS AND CONTAINERSSome pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.
If you miss a dose of Cyltezo, administer it as soon as you remember. Then continue with your next scheduled dose as prescribed by your doctor. Talk with your doctor or pharmacist if you have questions about a missed dose.
To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.
It’s important that you do not administer more Cyltezo than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose.
If you inject more than the recommended amount of Cyltezo
Call your doctor right away if you believe you’ve injected too much Cyltezo. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.
The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Cyltezo for you, they’ll prescribe the dosage that’s right for you. If you self-inject Cyltezo, always follow the dosage that your doctor prescribes.
As with any drug, never change your dosage of Cyltezo without your doctor’s recommendation. If you have questions about the dosage of Cyltezo that’s best for you, talk with your doctor.
Besides learning about dosage, you may want other information about Cyltezo. These additional articles might be helpful:
- More about Cyltezo. For information about other aspects of Cyltezo, refer to this article.
- Cost. If you’d like to learn about Cyltezo and cost, see this article.
- Details about your condition. For details about some of the conditions Cyltezo is prescribed to treat, see this list of psoriatic arthritis articles and our hubs on:
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.