Lybalvi (olanzapine/samidorphan) is a brand-name oral tablet that’s prescribed for bipolar 1 disorder and schizophrenia in adults. The cost of the drug, with and without insurance, can depend on several factors, such as whether Lybalvi has a savings program.

As with all medications, the cost of Lybalvi can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • whether Lybalvi has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Lybalvi will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Lybalvi prescription, explore these Optum Perks coupons.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

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Lybalvi is only available as a brand-name drug. It doesn’t come in a generic version. A generic drug is an exact copy of the active ingredient in a brand-name medication.

Generics tend to cost less than brand-name drugs.

WHY ARE COSTS DIFFERENT FOR BRAND-NAME DRUGS VS. GENERIC DRUGS?

Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you take Lybalvi long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Lybalvi. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

Using a mail-order pharmacy

Lybalvi may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for Lybalvi, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called the Lybalvi Co-Pay Savings Program is available. For more information and to find out whether you’re eligible for support, call 855-820-9624 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Lybalvi.

What is the cost of Lybalvi without insurance?

The price you’ll pay for Lybalvi if you don’t have insurance can vary based on several factors. But typically, the cost is higher for those without insurance.

There are other factors that could affect what you pay for this drug. These include:

  • the quantity you’re prescribed (such as a 90-day or 30-day supply)
  • whether you qualify for any available savings programs
  • your dosage
  • the pharmacy you use

To learn the exact cost you’d pay for this medication without insurance, ask your doctor or pharmacist. You may also want to contact several pharmacies to compare their prices for Lybalvi.

Check out Optum Perks* for estimates of Lybalvi’s price when using coupons from the site. (Optum Perks coupons cannot be used with insurance benefits or copays.)

*Optum Perks is a sister site of Medical News Today.

How does Lybalvi’s cost compare with that of other similar medications such as Latuda or Seroquel?

The price you’d pay for Lybalvi versus that of Latuda or Seroquel depends on various factors, including:

  • the length of your treatment
  • whether there are payment assistance programs for your prescribed treatment
  • whether you’re paying out of pocket or have insurance
  • whether a generic form of the drug is available

To learn more about the cost of Lybalvi compared with other treatments for your condition, talk with your doctor, pharmacist, or insurance provider.

Below is information you may want to consider if you have insurance and receive Lybalvi.

If you have insurance, your insurance company may require prior authorization before it covers Lybalvi. This means the company and your doctor will discuss Lybalvi in regard to your treatment. The insurance company will then determine whether the medication is covered.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Lybalvi requires prior authorization.

Now that you’ve learned about cost and Lybalvi, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Lybalvi. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you’d pay for Lybalvi.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.