Methotrexate is a generic drug prescribed for certain conditions, such as rheumatoid arthritis and some cancers. The cost of methotrexate with and without insurance can depend on several factors, such as whether the drug has a savings program.

The Food and Drug Administration (FDA) has approved the use of the drug to treat numerous conditions in adults. These conditions include:

The drug is also used in children for polyarticular juvenile idiopathic arthritis or acute lymphoblastic leukemia.

For more information about methotrexate, refer to this article.

Drug details

Here are some details on methotrexate:

  • Drug class: antimetabolite
  • Drug forms:
    • a solution given by intravenous, subcutaneous, intramuscular injection, or injection into a joint or the spinal canal
    • a powder that’s mixed with liquid to form a solution, given by intravenous, subcutaneous, or intramuscular injection, or injection into a joint or the spinal canal
    • an oral solution
    • an oral tablet
  • Brand-name versions:

Read on to learn about methotrexate and cost, and how to save money on prescriptions.

Methotrexate retail price
$150
Save up to $143 per fill off of the retail price
The retail price of methotrexate is $150. Save up to $143 per fill off of the retail price.

As with all medications, the cost of methotrexate can vary. Factors that may affect the price you’ll pay include your treatment plan, your insurance coverage, and the pharmacy you use. It may also depend on the cost of visits to your healthcare facility to receive doses of methotrexate.

In addition, you may need to purchase needles, syringes, or an auto-injector pen to use some forms of this drug.

To find out what the cost of methotrexate may be for you, talk with your doctor, pharmacist, or insurance provider.

To save money on your methotrexate prescription, explore these Optum Perks coupons.

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47201

Dosage

2.5mg methotrexate (24 Tablets)

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.

Pricing source:Perks.optum.com

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Here are answers to some frequently asked questions about drug cost and methotrexate.

What’s the price of methotrexate 2.5 mg?

It depends. Factors that may affect the price you’ll pay for 2.5 milligram (mg) doses of methotrexate include your treatment plan, your insurance coverage, and the pharmacy you use.

Your pharmacist may be able to help determine how much methotrexate 2.5 mg costs compared with other strengths and forms of the drug. They’ll use factors such as your insurance information and treatment plan to determine the price of this drug.

How does methotrexate’s cost differ with or without insurance? What might the drug cost per month?

With or without insurance, the cost of methotrexate can vary. In general, drug costs are usually higher without insurance.

If you have questions about how much methotrexate may cost, including its cost per month, talk with your pharmacist. They can take into account your treatment plan and insurance information to determine the cost you’ll pay for the drug.

You can also visit Optum Perks for methotrexate price estimates when using coupons from this site. (Optum Perks is a sister site of Medical News Today.) However, Optum Perks coupons cannot be used with insurance benefits or copays.

What’s the cost of injectable methotrexate compared with oral methotrexate?

Methotrexate shots may have different costs than the oral version of this drug. Your insurance coverage and which pharmacy you use can also affect the drug’s cost.

Your pharmacist may be able to help determine the price you’ll pay for injectable methotrexate compared with oral methotrexate.

I’m using methotrexate to treat psoriasis. How much might the drug cost?

It depends. Your treatment plan can affect how much methotrexate will cost you, as can your insurance coverage and the pharmacy you use.

If you have questions about how much this drug may cost you, talk with your pharmacist. They can consider your treatment plan and insurance information to help determine the cost you may pay for methotrexate.

What’s the cost of leflunomide vs. methotrexate?

The costs of leflunomide and methotrexate can vary. Factors that may affect the price you’ll pay include your treatment plan, your insurance coverage, and which pharmacy you use.

Your pharmacist can help compare the costs of leflunomide and methotrexate.

Methotrexate is available as several different brand-name drugs:

Otrexup and Rasuvo each come as a solution in an auto-injector pen. However, these drugs are only available as brand-name products. So, there’s no generic methotrexate injection pen currently available.

A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered as safe and effective as the original drug, and they tend to cost less than brand-name drugs. To find out how the cost of a brand-name drug containing methotrexate compares with the cost of generic methotrexate, talk with your doctor, pharmacist, or insurance provider.

If your doctor has prescribed methotrexate, and you’re interested in using a brand-name drug containing methotrexate instead, talk with your doctor. They may have a preference for one version or the other. You’ll also need to check with your insurance provider, as it may only cover one or the other.

Keep reading for information on some ways to reduce long-term drug costs with methotrexate treatment.

Getting a 3-month supply

You may be able to get a 90-day supply of methotrexate. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor or insurance provider.

Using a mail-order pharmacy

Methotrexate may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for methotrexate, consider looking into websites that offer cost resources and information. Two such organizations are Medicine Assistance Tool and NeedyMeds.

These sites can provide details on drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services.

Now that you’ve learned about cost and methotrexate, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance on cost issues relating to you and this drug. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for methotrexate.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.