Psoriasis is an autoimmune condition that causes cells to develop rapidly on the skin. This overgrowth can lead to thick, scaly plaques that may itch or cause discomfort.
Environmental triggers often cause symptoms of psoriasis to flare. While a person cannot cure these symptoms, recent developments in psoriasis treatment mean that they can reduce the number of flares, and their severity.
In this article, we explain the different psoriasis types, their symptoms, and how to treat them.
The main symptoms of psoriasis are red, flaky, crusty patches, that may have easily-shed, silvery scales covering them. They are also likely to cause an intense itching or burning sensation.
Symptoms of psoriasis develop in flares that occur for different lengths of time with periods of remission in between when they clear up. Remission periods last for an average of 1–12 months at a time.
The duration of both flares and periods of remission can be challenging to predict, however.
Symptoms range from mild to severe and may present differently, according to the type of psoriasis.
According to the National Psoriasis Foundation:
- mild psoriasis covers less than 3% of the body
- moderate psoriasis covers 3–10% of the body
- severe psoriasis covers in excess of 10% of the body
Plaques might develop anywhere but commonly occur as small patches on the elbows, knees, lower back, and scalp.
There are several forms of psoriasis, as described below.
About 80–90% of people with psoriasis have plaque psoriasis. It usually shows as raised, inflamed, red lesions, covered by silvery, white scales, most often on the elbows, knees, scalp, and lower back.
Inverse psoriasis develops in the following areas:
- the armpits
- the groin
- under the breasts
- other skin folds, such as around the genitals and buttocks
Inverse psoriasis has red lesions, usually without the scales that occur in plaque psoriasis. The lesions might be smooth and shiny.
Irritation from rubbing and sweating can make this type of psoriasis worse due to its location in skin folds and tender areas. It is more common in people who are overweight and those with deep skin folds.
Erythrodermic psoriasis is a particularly inflammatory but rare type that can cause large areas of fiery redness across the surface of the body.
People with unstable plaque psoriasis, where lesions do not have clearly defined edges, may develop erythrodermic psoriasis. There may also be exfoliation, or peeling of the skin, severe itching, and pain.
Erythrodermic psoriasis disrupts the body’s chemical balance. This interference may cause protein and fluid loss that can lead to severe illness.
The complications of erythrodermic psoriasis can be dangerous. Anyone who shows symptoms of this condition should see a doctor right away.
People with erythrodermic psoriasis may spend time in the hospital if symptoms are severe.
Guttate psoriasis often starts in childhood or young adulthood. It appears as small, red, individual spots on the skin. The spots are not usually as thick or as crusty as the lesions in plaque psoriasis.
A range of conditions can trigger guttate psoriasis, including:
- upper respiratory infections
- streptococcal infections
- injury to the skin
- certain medications, including antimalarials, lithium, and beta-blockers.
Guttate psoriasis may resolve without treatment and never return. However, it may clear and reappear later as patches of plaque psoriasis.p
Pustular psoriasis affects adults more than children, and it accounts for fewer than 5% of psoriasis cases.
It appears as white pustules, or blisters of noninfectious pus, which red skin surrounds. It can affect certain areas of the body, for example, the hands and feet, or most of the body. It is not an infection, and it is not contagious.
Pustular psoriasis tends to have a cycle, in which the formation of pustules and scaling follows reddening of the skin.
While psoriasis can form anywhere on the human body, below are some of the most common areas.
Other health problems may develop as a result of psoriasis. While some people think of it as a skin disease, psoriasis can also affect the bones, the muscles, and the metabolic system.
This type of psoriasis causes inflammation and progressive damage to the joints. It occurs most commonly when people are between 30 and 50 years of age.
People with psoriasis may experience social exclusion, image issues, and low self-esteem. Together with the physical discomfort, itching, and pain of psoriasis, this can impact on their overall quality of life.
The social and physical demands of this chronic disease may contribute to depression and anxiety. People with psoriasis have a risk of depression that is twice as high as those who do not have the condition.
While the cause of psoriasis is still unclear, scientists believe that it is an autoimmune disease.
Autoimmune diseases affect the immune system, which produces T cells to protect the body against infectious agents.
In people with psoriasis, triggers can lead to their genes instructing the immune system to target the wrong cells. T cells respond to a trigger as if they are fighting an infection or healing a wound. They produce chemicals that cause inflammation.
In psoriasis, this autoimmune activity leads to the excessive growth of skin cells. Typically, skin cells take about 21–28 days to replace themselves. However, in people with psoriasis, they take around 2–6 days.
Triggers will be different in each individual with psoriasis, but common triggers include:
- stress and anxiety
- injuries to the skin
- hormonal changes
Medications that can trigger a psoriasis flare include:
Some people associate psoriasis with allergies, diet, and weather, but no evidence has yet supported these theories.
Importantly, psoriasis is not contagious. Knowing this can help people with the disease cope with the more challenging parts of socializing.
Some factors increase the risk of a person developing psoriasis.
These factors include:
- having cardiovascular disease and metabolic syndrome
- trauma to the skin
- family history of the condition
About 1 in 3 people with a close relative who has psoriasis will also develop the condition. If one parent has psoriasis, there is a 10% chance that their child will go on to develop the disease. This risk increases to 50% if both parents have psoriasis.
This correlation in families suggests an underlying genetic component. However, symptoms of the disease may not show unless an environmental factor triggers it to become active. At least 10% of the population may have the gene that causes psoriasis, but only 2–3% of people develop it.
Among younger people, psoriasis may flare after an infection, notably strep throat. Symptoms will become noticeable 2–6 weeks after an earache or respiratory infection in 33–50% of young people with psoriasis. Common respiratory infections include strep throat, bronchitis, and tonsillitis.
Psoriasis is equally common in males and females. It can begin at any age, but it is most common between 15–35 years. The average time of onset is 28 years of age.
Around 10–15% of people with psoriasis develop the condition before they are 10 years of age.
There are no blood tests that can confirm psoriasis.
A person who has a persistent rash that does not resolve with over-the-counter (OTC) remedies may want to talk to a doctor about psoriasis. Often, recognizing and treating symptoms early on improves the long-term outcomes of psoriasis.
A doctor will examine the symptoms and ask about personal and family history. They might also carry out a skin biopsy to rule out other conditions, such as eczema.
If a doctor confirms psoriasis, treatment will depend on the type and severity of the condition. The main options include medications and phototherapy.
People with psoriasis should use emollients to keep the skin moisturized when taking other treatments. This precaution can help reduce the itching and irritation and may reduce the number of lesions or plaques that develop.
A range of topical, oral, and injected medications is available for people with psoriasis.
Some OTC remedies can help relieve the symptoms of very mild psoriasis. These include:
- Coal tar: This can help soothe plaque psoriasis, itching, and lesions on the scalp, palms, and soles. People can use coal tar on its own or alongside another treatment.
- Hydrocortisone creams: These reduce inflammation and soothe itching.
- Salicylic acid: This can help reduce swelling and remove scales, often in people with scalp psoriasis.
- Anti-itch agents: These might include products containing calamine, hydrocortisone, camphor, or menthol.
People apply topical treatments directly to the skin. It is usually the first-line treatment for mild-to-moderate symptoms that aims to slow down the growth of skin cells, reduce inflammation, and soothe itching or discomfort.
These treatments are available over the counter or on prescription and include nonsteroids and steroids.
- Corticosteroids: People have used these to treat psoriasis for decades. There are many different steroids available as gels, foams, creams, sprays, and ointments. The National Psoriasis Foundation offer a guide on understanding corticosteroid strengths here.
- Synthetic vitamin D: People often use this alongside a corticosteroid. It can help flatten plaques, slow growth of skin cells, and remove scales.
- Retinoids: This is synthetic vitamin A that can help slow the growth of skin cells, reduce redness, and soothe itching. People commonly combine Tarazotene, a topical retinoid, with corticosteroid treatment or UVB light therapy.
- Pimecrolimus cream and tacrolimus ointment: These are eczema treatments that a doctor may prescribe to help symptoms of inverse and plaque psoriasis. People often combine them with a course of steroids.
Systemic therapies work through the whole-body system, and doctors prescribe them for people who have moderate-to-severe psoriasis and psoriatic arthritis. They reduce disease progression and the regularity of flares.
Biologics: These are protein-based drugs that derive from living cells. Biologics target the T cells and immune proteins that cause psoriasis and psoriatic arthritis.
Biologics are effective, and their benefits far outweigh their risks.
However, people should consider costs when seeking biologic treatment, and it is sensible to speak to an insurance provider about potential coverage.
Methotrexate: Doctors prescribe this for extremely severe psoriasis that restricts daily function and does not respond to any other treatments. Methotrexate is effective for psoriatic arthritis, as well as erythrodermic, palmoplantar, and nail psoriasis.
Cyclosporine: Doctors usually prescribe this for preventing the rejection of organs after transplants. However, it can also help people with severe presentations of the following types of psoriasis:
- generalized pustular
Oral retinoids: People with severe psoriasis can take a drug called acitretin that works against the effects of the disease throughout the body. It does not reduce immune activity, making acitretin safer for people with HIV who also have severe psoriasis.
People with all types psoriasis except inverse psoriasis may benefit from oral retinoids.
Doctors may prescribe certain off-label medications if the standard, FDA-approved drugs have not resolved symptoms, or if the individual has another condition that prevents the use of specific medications.
Effective off-label options for psoriasis include:
- fumaric acid esters
Phototherapy involves regularly exposing the skin to ultraviolet light under medical supervision. The light can slow cell growth, suppress immune activity, and reduce irritation.
People can carry out phototherapy at home using a lightbox or handheld device if their initial treatment is successful.
Some people may need to take psoralen pills before exposure to make their skin more sensitive to light.
It is not possible to avoid psoriasis flares, but some strategies can help reduce the risk of a flare occurring.
- reducing stress with yoga, exercise, meditation, or all of these
- eating a balanced diet and maintaining a healthy weight
- recognizing and avoiding food triggers
- joining a support group or blog to talk to others with similar experiences
- not smoking or drinking alcohol to excess
Home remedies for reducing itching include:
- Keeping the skin moisturized. A dermatologist can recommend a suitable product.
- Taking a cold shower for up to 10 minutes or using a cold pack. Avoid hot showers, as they can dry the skin
While psoriasis can be isolating and uncomfortable, people have many options for managing symptoms and treating the immune activity of the disease.
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