Motegrity interactions: Alcohol, medications, and other factors

Before you start treatment with Motegrity, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Motegrity interacts with supplements, herbs, or vitamins, see the “Motegrity and other interactions” section below.)

Motegrity has been found to interact with fosfomycin (Monurol). Specifically, Motegrity can make fosfomycin less effective. For details about this, see the “Drug interactions in-depth” section below.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

In some cases, factors or conditions could prevent your doctor from prescribing Motegrity due to the risk of harm. These are known as contraindications. The contraindications of Motegrity include:

Having a tear or blockage in your intestine

Your doctor likely won’t prescribe Motegrity if you have a perforation (tear) in the wall of your intestine. And they’ll likely not prescribe Motegrity if you have a blockage in your intestine caused by a problem with the structure or function of your intestine.

Taking Motegrity increases the muscular contractions in your intestine, which could be dangerous in these situations. Ask your doctor about other treatments that may be better choices for you.

Having severe inflammatory bowel disease

If you have severe inflammatory bowel disease (IBD), your doctor will likely not prescribe Motegrity. Examples of severe IBD include Crohn’s disease, ulcerative colitis, and toxic megacolon.

Taking Motegrity increases the muscular contractions in your intestine, which could be dangerous in these situations. Ask your doctor about other treatments that may be better choices for you.

Having had an allergic reaction to Motegrity or any of its ingredients

If you have had an allergic reaction to Motegrity or any of its ingredients, your doctor will likely not prescribe Motegrity. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.

Note: Before you start treatment with Motegrity, it’s important to tell your doctor if these contraindications apply to you. They can determine whether to prescribe Motegrity.

There aren’t any known interactions between Motegrity and alcohol. However, your doctor may advise you to avoid or limit alcohol consumption during Motegrity treatment.

This is because drinking alcohol while taking the drug may worsen some of Motegrity’s side effects. For example, you may experience:

• nausea
• headache
• dizziness
• diarrhea

If you consume alcohol during Motegrity treatment, these side effects may be more likely to occur. If you have questions about drinking alcohol while taking Motegrity, talk with your doctor.

Here’s a closer look at a drug interaction of Motegrity.

Fosfomycin (Monurol)

Fosfomycin (Monurol) is an antibiotic prescribed to treat some urinary tract infections (UTIs) caused by bacteria.

Interaction result: Taking Motegrity with fosfomycin could make this antibiotic less effective.

Interaction explained: Motegrity increases the muscular contractions in your intestines, so it can make fosfomycin move through your digestive system faster than it should. This can reduce the amount of fosfomycin that’s absorbed into your bloodstream and then excreted in your urine. Excreting a lower amount of fosfomycin in your urine can make the drug less effective at treating a UTI.

Steps you or your doctor may take: To treat a UTI, fosfomycin is taken as a single dose. If your doctor prescribes fosfomycin with Motegrity, they may recommend taking your fosfomycin dose at a different time of day than your Motegrity dose.

If you still have UTI symptoms after taking fosfomycin with Motegrity, talk with your doctor.

Motegrity may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Motegrity.

Motegrity and supplements

It’s possible for drugs to interact with supplements such as vitamins and herbs.

Motegrity and herbs

There are no specific reports of herbs interacting with Motegrity. However, that doesn’t mean herbal interactions won’t occur or be recognized in the future. Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during Motegrity treatment.

Motegrity and vitamins

There are no specific reports of vitamins interacting with Motegrity. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking these products with Motegrity.

Motegrity and food

There were no reports of food interactions with Motegrity. If you’d like to learn more about eating certain foods during treatment with Motegrity, talk with your doctor.

Motegrity and vaccines

There aren’t any known interactions between Motegrity and vaccines. Talk with your doctor or pharmacist to find out whether you’re due for any vaccines.

Motegrity and lab tests

Motegrity isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk with your doctor.

MOTEGRITY INTERACTION WITH CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Motegrity. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Motegrity. The effects of cannabis may affect how well you stick to your Motegrity treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Motegrity. Before you take this drug, be sure to talk with your doctor about your health history. Motegrity may not be the right treatment option for you if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Motegrity include:

• Allergic reaction: If you’ve had an allergic reaction to Motegrity or any of its ingredients, your doctor will likely not prescribe Motegrity. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
• Blockage, tear, or serious inflammation in your intestine: If you have a blockage, tear, or serious inflammation in your intestine, your doctor will likely not prescribe Motegrity. For more information, see the section above called “When to avoid Motegrity.”
• History of depression or suicidal thoughts: Motegrity may cause or worsen depression and suicidal thoughts. If you have a history of depression or suicidal thoughts, talk with your doctor about whether Motegrity is right for you. If you take Motegrity, talk with your doctor right away if you have any changes in your mood, feelings, thoughts, or behavior.
• Kidney problems: Your kidneys help clear Motegrity from your body. If you have severe kidney problems, Motegrity can build up in your body. As this can raise your risk of side effects,* tell your doctor if you have kidney problems. They may prescribe a dosage of Motegrity that’s lower than usual.† Doing so may help reduce your risk.
• Breastfeeding: It’s not known whether it’s safe to take Motegrity while breastfeeding. The drug passes into breast milk, but it’s not known what effects Motegrity may have on a child who is breastfed. If you’re breastfeeding or planning to, talk with your doctor before taking Motegrity. They can talk with you about treatment options and ways to feed your child.
• Pregnancy: There haven’t been enough clinical trials to determine whether Motegrity is safe to take while pregnant. Animal studies did not find any harmful effects when Motegrity was given to pregnant animals. However, it’s important to note that animal studies don’t always indicate what may happen in humans. If you’re pregnant or planning to become pregnant, tell your doctor before starting Motegrity. They can advise you on the right treatment plan for you.

* For details about side effects of Motegrity, see this article.
† To learn about Motegrity and dosage, see this article.

You can take certain steps to help prevent interactions with Motegrity. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

• Let them know if you drink alcohol or use cannabis.
• Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
• Create a medication list, which your doctor and pharmacist can help you fill out.

It’s also important to read the Motegrity label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Motegrity doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

You can also help prevent interactions with Motegrity by taking it exactly as your doctor prescribes.

Besides learning about interactions, you may want to find out more about Motegrity. These resources might help:

• Overview of Motegrity: For a general overview of Motegrity, you can see this article.
• Side effects: If you’re interested in the side effects of Motegrity, see this article. Another option is to refer to the Motegrity prescribing information.
• Dosage specifics: To learn about the dosage of Motegrity, see this article.
• Cost: If you’d like to learn about Motegrity and cost, see this article.
• Facts about chronic constipation: To learn more about chronic constipation, see our list of constipation articles.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.