Omeprazole is a generic medication that’s available over the counter (OTC) and as a prescription. The drug is approved by the Food and Drug Administration (FDA) for the following in adults and certain children:

Drug details

Here are some details on omeprazole:

  • Drug class: proton pump inhibitor (PPI)
  • Drug forms: delayed-release capsules and tablets, disintegrating oral tablets, oral suspension (in combination with other medications), granules in a packet for mixing into a liquid solution
  • Brand-name versions: Prilosec (granules in a packet), Prilosec OTC (delayed-release tablet)

Combination products containing omeprazole

Omeprazole may be used in combination with other medications to treat certain conditions. Some products contain multiple medications, including omeprazole, in one form. These include:

  • Zegerid and Zegerid OTC. These brand-name drugs contain omeprazole/sodium bicarbonate. They’re used to treat duodenal ulcers, stomach ulcers, and erosive esophagitis in adults.
  • Talicia. This brand-name drug contains omeprazole/amoxicillin/rifabutin. It’s used to treat Helicobacter pylori infection in adults.

Keep in mind that sometimes combination products aren’t exactly the same between brand-name and OTC versions. If your doctor recommends one of the combination products above, it’s important that you use the specific product they mention. For more information on these combination products that contain omeprazole, talk with your doctor or pharmacist.

Read on to learn about omeprazole and cost, and how to save money on prescriptions.

As with all medications, the cost of omeprazole can vary. Factors that may affect the price you’ll pay include your treatment plan, your insurance coverage, the form of omeprazole you use, and the pharmacy you use.

To find out what the cost of omeprazole will be for you, talk with your doctor, pharmacist, or insurance provider.

Here are answers to some frequently asked questions about drug price and omeprazole.

Does the price of omeprazole vary by strength?

The price of omeprazole might depend on the form and strength. Here are the drug’s forms and strengths in milligrams (mg).

Omeprazole formStrength
delayed-release capsule10 mg, 20 mg, 40 mg
delayed-release tablet20 mg
disintegrating oral tablet20 mg
powder (granules) that comes in packets2.5 mg and 10 mg

Omeprazole is also an ingredient in some combination medications.* The drugs Zegerid* and Zegerid OTC* contain omeprazole/sodium bicarbonate. These products come as capsules and a liquid suspension that you swallow. Zegerid and Zegerid OTC contain omeprazole in the following strengths: 20 mg and 40 mg.

The drug Talicia* contains omeprazole/amoxicillin/rifabutin. Talicia comes as delayed-release capsules that contain one strength of omeprazole: 10 mg.

* For information on these drugs’ uses, see the “Overview of omeprazole” section above.

Is it possible to buy omeprazole in bulk?

If your doctor prescribes omeprazole, you may be able to get a 90-day supply in bulk.

It’s also possible to buy some forms and strengths of omeprazole in bulk over the counter (OTC). With OTC drugs, you don’t need a prescription for the medication.

The following forms and strengths of omeprazole are available OTC. Strengths are listed in milligrams (mg):

  • delayed-release capsule (10 mg, 20 mg)*
  • delayed-release tablet (20 mg)
  • disintegrating oral tablet (20 mg)

However, these forms of omeprazole should not be used for more than 14 days in a row without your doctor’s approval. Be sure to check with your doctor or pharmacist before using any OTC medication, including omeprazole.

If you’re interested in getting a 90-day supply of your omeprazole prescription, see the “Ways to reduce long-term drug costs” section below. And if you’d like to learn about getting OTC omeprazole in bulk, talk with your pharmacist.

* The 40-mg strength of omeprazole delayed-release capsules is available only with a prescription.

What’s the price of omeprazole without insurance?

If you’re prescribed omeprazole, the cost without insurance can vary. It’s possible that the drug might cost more without insurance than with it.

If you have questions about the cost of omeprazole without insurance, talk with your pharmacist. They may be able to help determine how much you’ll pay for omeprazole without insurance.

Keep in mind that tablet forms of omeprazole are available over the counter (OTC). You can check with your local pharmacy, or online retailers, for the OTC cost of omeprazole.

Below are some details on potential ways to reduce long-term drug costs, including costs you pay for omeprazole.

Getting a 3-month supply

You may be able to get a 90-day supply of omeprazole. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor or insurance provider.

Using a mail-order pharmacy

Omeprazole may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

Omeprazole is a generic drug, which is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs.

Omeprazole is available as the brand-name drugs Prilosec and Prilosec OTC. To find out how the cost of Prilosec or Prilosec OTC compares with the cost of omeprazole, talk with your doctor, pharmacist, or insurance provider.

If you’ve been prescribed omeprazole and you’re interested in using Prilosec or Prilosec OTC instead, talk with your doctor. They may have a preference for one version or the other. You’ll also need to check your insurance provider, as it may only cover one or the other. Keep in mind that forms may vary between generic omeprazole and the brand-name drugs.

Omeprazole is also found in some combination medications. Some of these are available as brand-name drugs, generics, or both.

  • Zegerid and Zegerid OTC. These brand-name drugs contain omeprazole/sodium bicarbonate. They’re used to treat duodenal ulcers, stomach ulcers, and erosive esophagitis in adults. Zegerid and Zegerid OTC are available as the generic drug omeprazole/sodium bicarbonate.
  • Talicia. This brand-name drug contains omeprazole/amoxicillin/rifabutin. It’s used to treat Helicobacter pylori infection in adults. Talicia is not available as a generic.

If your doctor prescribes Zegerid or Zegerid OTC, ask them whether they prefer the brand-name or generic version.

Note: Keep in mind that sometimes combination products aren’t exactly the same between brand-name and over-the-counter versions. If your doctor recommends one of the combination products mentioned above, it’s important that you use the specific product they mention. For more information on these combination products that contain omeprazole, talk with your doctor or pharmacist.

If you need financial support to pay for omeprazole, consider looking into websites that offer cost resources and information. Two such organizations are:

These sites can provide details on drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services.

Now that you’ve learned about cost and omeprazole, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance on cost issues related to you and omeprazole. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for omeprazole.

Here are some other references you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.