Plaquenil interactions: Alcohol, medications, and other factors

Plaquenil interactions with other medications

Before you start treatment with Plaquenil, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions.

This table lists drugs that can interact with Plaquenil. Keep in mind that this table doesn’t include all drugs that may interact with Plaquenil. Some of these interactions are described in the “Drug interactions in depth” section.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

To learn whether Plaquenil interacts with supplements, herbs, or vitamins, see the “Plaquenil and other interactions” section.

When to avoid Plaquenil

In some cases, factors or conditions could prevent your doctor from prescribing Plaquenil due to the risk of harm. These are known as contraindications.

Plaquenil has one contraindication, as follows:

Known allergy to Plaquenil, any of its ingredients, or similar drugs: If you ever had an allergic reaction to Plaquenil or any of its ingredients, your doctor likely will not prescribe Plaquenil. They also won’t usually prescribe Plaquenil if you’ve had an allergic reaction to similar drugs known as 4-aminoquinolines. An example of these drugs is chloroquine.

Taking Plaquenil in these situations could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Note: Before you start treatment with Plaquenil, it’s important to tell your doctor whether this contraindication applies to you. They can then determine whether to prescribe Plaquenil.

Plaquenil and alcohol

Plaquenil isn’t known to interact with alcohol. However, certain side effects from Plaquenil could be worsened by drinking alcohol. Examples of these side effects include headache, nausea, and dizziness.

In addition, drinking large amounts of alcohol can damage your liver. Plaquenil may also cause liver problems, such as liver failure. So drinking alcohol with Plaquenil could increase your risk of liver problems.

If you drink alcohol, talk with your doctor about how much, if any, is safe to consume while you’re taking Plaquenil.

Drug interactions in depth

Here’s a closer look at certain drug interactions of Plaquenil.

Diabetes medications

Diabetes medications help lower your blood sugar levels. Taking Plaquenil with diabetes medications can increase the effect of the diabetes medications. This is because Plaquenil also can lower your blood sugar. This makes it more likely that hypoglycemia (low blood sugar) can occur, which can sometimes be severe.

Symptoms of hypoglycemia can include:

• irritability
• hunger
• dizziness
• confusion
• blurred vision
• trouble with coordination
• fast heartbeat
• tremor

Examples of diabetes medications that may interact with Plaquenil include:

• insulin lispro (Humalog)
• insulin glargine (Lantus)
• glipizide (Glucotrol XL)
• repaglinide

Steps you or your doctor may take

If you take Plaquenil with a diabetes medication, your doctor may recommend checking your blood sugar more frequently. They may also lower your dosage of diabetes medication to reduce your risk of hypoglycemia.

Be sure to ask your doctor what to do if you have symptoms of hypoglycemia while taking Plaquenil.

Antacids

Antacids relieve indigestion and heartburn. Taking an antacid with Plaquenil could make Plaquenil less effective.

Antacids neutralize the acid in your stomach. This can affect the way your body absorbs other drugs from your digestive system. Taking an antacid with Plaquenil may reduce the level of Plaquenil that’s absorbed into your bloodstream. This means you may not get the full dose of Plaquenil, which could make it less effective.

Examples of antacid drugs that may interact with Plaquenil include:

• calcium carbonate (Tums, Alka-Seltzer)
• calcium hydroxide/magnesium hydroxide (Rolaids)
• aluminum hydroxide/magnesium hydroxide/simethicone (Maalox, Mylanta)

Steps you or your doctor may take

You should avoid taking antacids 4 hours before and 4 hours after taking Plaquenil. If you have indigestion or heartburn during this time, talk with your doctor or pharmacist. They can recommend other ways to relieve your symptoms.

Drugs that can affect your heart rhythm

Several drugs can cause heart-related side effects, and some can affect your heart rhythm. Certain drugs, including Plaquenil, can lengthen part of your heart rhythm called the QT interval. This is called long QT syndrome, which can make it harder for your heart to beat correctly. It can cause serious and sometimes life threatening irregular heartbeats.

Taking Plaquenil with other drugs that can cause long QT syndrome can increase your risk of this side effect.

Examples of drugs that can increase the risk of abnormal heart rhythms with Plaquenil include:

• certain drugs taken to treat irregular heart rhythms, such as amiodarone (Pacerone), flecainide, and sotalol (Betapace, Sorine)
• certain antimalarials, such as artemether/lumefantrine (Coartem), mefloquine, and chloroquine
• certain antibiotics, such as clarithromycin, azithromycin (Zithromax), and ciprofloxacin (Cipro)
• certain antipsychotics, such as aripiprazole (Abilify), chlorpromazine, and haloperidol (Haldol)
• certain antidepressants, such as citalopram (Celexa) and mirtazapine (Remeron)

Steps you or your doctor may take

Before starting Plaquenil treatment, be sure to tell your doctor about any other medications you take. Due to the serious risk associated with this interaction, your doctor likely will not prescribe Plaquenil with other drugs that can lengthen the QT interval. You can talk with your doctor about other treatment options for your condition.

Plaquenil and other interactions

Some medications can interact with supplements, foods, vaccines, or even lab tests. Keep in mind that the following information does not include all other interactions possible with Plaquenil.

Plaquenil and supplements

Plaquenil currently has no reports of interacting with herbs or vitamins. But that doesn’t mean interactions with herbs or vitamins won’t occur or be recognized in the future.

Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during Plaquenil treatment.

Plaquenil and food

Plaquenil currently has no reports of interactions with food.

It’s important that you take Plaquenil with food or a glass of milk. You should not take the medication on an empty stomach. Taking Plaquenil on an empty stomach can increase your risk of digestive side effects from the drug, including indigestion.

Also, you should not take medication for indigestion at least 4 hours before or 4 hours after taking Plaquenil. The best way to help prevent indigestion is by taking your dose with food or a glass of milk. (See the discussion about antacids in the “Drug interactions in depth” section for more information.)

If you’d like to learn more about eating certain foods during treatment with Plaquenil, talk with your doctor.

Plaquenil and vaccines and lab tests

Plaquenil currently has no reports of interacting with vaccines or lab tests. However, that doesn’t mean interactions with vaccines or lab tests won’t occur or be recognized in the future.

To be safe, talk with your doctor or pharmacist before getting any vaccines while taking Plaquenil. Also, you should talk with your doctor or pharmacist if you need any lab tests during Plaquenil treatment.

PLAQUENIL AND CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been reported to interact with Plaquenil. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Plaquenil. The impact of cannabis may affect how well you adhere to your Plaquenil treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Plaquenil and health-related interactions

Certain medical conditions and other factors may increase the risk of interactions with Plaquenil. Before you take this drug, be sure to talk with your doctor about your health history. Plaquenil may not be the right treatment option if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Plaquenil include the following:

Allergic reaction: If you’ve ever had an allergic reaction to Plaquenil, any of its ingredients, or similar drugs such as chloroquine, your doctor likely will not prescribe Plaquenil. To learn more, see the “When to avoid Plaquenil” section.

Heart condition: Plaquenil may affect your heart. You may have an increased risk of heart-related side effects if you:

• have heart disease, such as heart failure
• ever had a heart attack
• have a heart condition such as a slow or irregular heartbeat or have an irregular heart rhythm called long QT syndrome

You can talk with your doctor about whether Plaquenil is safe for you.

Kidney or liver problems: Plaquenil can sometimes cause liver and kidney problems. If you already have a liver or kidney problem, the drug could worsen your condition.

Plaquenil could also build up in your body if you have a liver or kidney problem. These organs are responsible for clearing the medication from your body. If they aren’t working correctly, the level of Plaquenil in your system could rise, which could increase your risk of side effects.

Due to these risks, your doctor may prescribe a Plaquenil dosage that’s lower than usual. They may also monitor you more closely for possible side effects.

Psoriasis: If you have psoriasis, Plaquenil could worsen it. Due to this risk, your doctor may not prescribe Plaquenil. They can advise you on other treatment options that may be better for you.

Porphyria: If you have a rare genetic condition called porphyria, Plaquenil could worsen it. Due to this risk, your doctor may not prescribe the drug. You can ask them about other treatments.

Low blood cell counts: Plaquenil can lower levels of red blood cells, white blood cells, and platelets. If you already have a low blood cell count, such as anemia, Plaquenil could worsen it. Your doctor will likely monitor your blood cell levels more often while you take Plaquenil. Or they may recommend a different medication for your condition.

G6PD deficiency: Glucose-6-phosphate dehydrogenase (G6PD) is a protein that keeps your red blood cells healthy. If you have a G6PD deficiency, you don’t have enough G6PD in your blood. In this case, taking Plaquenil may destroy red blood cells, which can lead to anemia.

If you have a G6PD deficiency, your doctor may monitor your blood cells more often while you take Plaquenil. Or they may recommend a medication other than Plaquenil for your condition.

Neurological condition: Plaquenil can sometimes cause seizures or other problems affecting your nervous system and muscles, such as movement problems. If you have epilepsy or another neurological condition, Plaquenil could worsen your symptoms. Be sure to talk with your doctor about whether the drug is right for you.

Pregnancy: It’s not known whether Plaquenil is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor about the possible risks and benefits of taking Plaquenil.

Breastfeeding: Plaquenil can pass into breast milk in small amounts. No reports have been made about side effects in children exposed to Plaquenil through breast milk. However, it’s not known whether the medication is safe to take while breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about the best way to feed your child while taking Plaquenil.

Mental health condition: On rare occasions, Plaquenil may cause suicidal thoughts or behaviors. If you have a mental health condition, such as depression, you may have an increased risk of this side effect. You can talk with your doctor about whether Plaquenil is the right treatment option.

Note: For information about Plaquenil’s side effects, see this article.

FAQ about Plaquenil and interactions

Here are some frequently asked questions about Plaquenil and possible interactions.

Is there an interaction between melatonin and Plaquenil?

No, specific reports of Plaquenil interacting with melatonin (a supplement often taken as a sleep aid) aren’t known.

However, both Plaquenil and melatonin can sometimes cause nausea, dizziness, or headaches. So you may have an increased risk of these side effects if you take melatonin during Plaquenil treatment. If you’re interested in taking melatonin, you should check with your doctor first.

Can I take acetaminophen if I’m taking Plaquenil?

In general, yes, it’s safe to take acetaminophen with Plaquenil. Reports of these medications interacting with each other aren’t known.

However, keep in mind that both acetaminophen and Plaquenil can cause liver problems, including liver damage. This side effect isn’t likely with acetaminophen unless you take higher doses than recommended. Your risk is also increased if you consume alcohol and take these medications together.

Before taking acetaminophen or any over-the-counter medication, talk with your doctor or pharmacist. They can advise you whether the medication is safe for you and the correct dosage.

Do Ozempic and Plaquenil (hydroxychloroquine) have interactions?

No major interaction between Ozempic (semaglutide) and Plaquenil (hydroxychloroquine) has been reported. But both drugs can affect your blood sugar level. So taking them together could cause your blood sugar to become too low.

Before you start treatment with Plaquenil, let your doctor know if you use Ozempic.

Preventing interactions

You can take certain steps to help prevent interactions with Plaquenil. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

• Let them know if you drink alcohol or use cannabis.
• Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
• Create a medication list, which your doctor and pharmacist can help you fill out.

It’s also important to read the Plaquenil label and other paperwork that may come with the drug. The label may have colored stickers that mention interactions. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions. (If Plaquenil doesn’t come with paperwork, you can ask your pharmacist to print a copy.)

If you need help reading or understanding this information, ask your doctor or pharmacist.

You can also help prevent interactions with Plaquenil by taking it exactly as your doctor prescribes.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.