Alcoholic liver disease is liver damage from overconsuming alcohol. It can cause a buildup of fats, inflammation, and scarring.
The liver is one of the most complex organs in the human body, with over 500 functions. These include:
- filtering blood toxins
- storing energy
- making hormones and proteins
- regulating cholesterol and blood sugar
According to the
This article explores the early signs and symptoms of alcoholic liver disease, its stages, causes, risk factors, treatments, and prevention.
A note about sex and gender
Sex and gender exist on spectrums. This article will use the terms “male,” “female,” or both to refer to sex assigned at birth. Click here to learn more.
Alcoholic liver disease has
- alcoholic fatty liver disease
- alcoholic hepatitis
Liver damage can affect the whole body. Once damage begins, it can take a long time to become noticeable, as the liver is generally highly effective at regenerating and repairing itself. Often, by the time doctors detect the damage, it is irreversible.
Signs and symptoms
The early signs of alcoholic liver disease are vague and affect a range of systems in the body.
Along with a general feeling of being unwell, signs can include:
It can be easy for someone to dismiss the early symptoms as the effects of a stomach bug or general malaise. However, leaving these symptoms undiagnosed and untreated — especially while continuing to consume alcohol — can lead to a faster progression of liver disease over time.
Drinking a large volume of alcohol can cause fatty acids to collect in the liver. Sometimes, heavy drinking over a short period, even less than a week, can cause this.
There are normally no symptoms, and alcoholic fatty liver disease is often reversible if the individual abstains from alcohol from this point onward.
If a person continues to drink alcohol it will lead to ongoing liver inflammation. This can occur after many years of heavy drinking. It can also occur acutely during periods of binge drinking.
Common symptoms of alcoholic hepatitis are:
- jaundice, or a yellow tint of the whites of the eyes and the skin
- enlarged liver, known as hepatomegaly
- features of a systemic inflammatory response, including any of the
Alcoholic hepatitis usually progresses to cirrhosis if a person continues to drink alcohol. Hepatitis
Fibrosis is a buildup of certain types of protein in the liver, including collagen. It features in most types of chronic liver disease.
To determine the extent of fibrosis, doctors use the Metavir scoring system on a scale from A0–A3:
- A0: no activity
- A1: mild activity
- A2: moderate activity
- A3: severe activity
Mild-to-moderate forms of fibrosis
The Metavir system also
- F0: absence of fibrosis
- F1: fibrosis with no scar tissue
- F2: fibrosis with occasional scar tissue
- F3: extensive scarring but no cirrhosis
- F4: cirrhosis
Cirrhosis occurs when the liver has been inflamed for a long time, leading to scarring and loss of function. This can be a life threatening condition. Cirrhosis damage is irreversible, but a person can prevent further damage by continuing to avoid alcohol.
Lifelong abstinence can improve liver function, but the permanent and severe damage from cirrhosis might mean that the person needs a liver transplant to survive.
As the liver no longer processes toxins properly, a person will be more sensitive to medications and alcohol. Alcohol use speeds up the liver’s destruction, reducing the liver’s ability to compensate for the current damage.
Once the alcoholic liver disease progresses, its symptoms become easier to recognize.
The more distinctive signs of late-stage liver disease, such as cirrhosis or fibrosis, include the following:
- edema, or swelling of the lower limbs
- a buildup of fluid in the abdomen — ascites
- fever and shivering
- extremely itchy skin
- fingernails that curve excessively — clubbing
- losing a significant amount of weight
- general weakness and wasting muscles
- blood in vomit and stools
- bleeding and bruising more easily
- more sensitive reactions to alcohol and drugs
Several factors increase the risk of alcoholic liver disease.
People who drink beer and liquor may be
Females are more susceptible to the negative effects of alcohol, even at the same levels of alcohol intake as males, so are
According to the American College of Gastroenterology, females who consume more than two drinks per day and males who consume more than three drinks per day for more than 5 years are at an increased risk for alcoholic liver disease.
Having hepatitis C increases the risk, and a person who consumes alcohol regularly and has had any type of hepatitis faces a higher chance of developing liver disease.
Genetic changes can affect the risk. If a person experiences changes in the genetic profiles of particular enzymes that are key to alcohol metabolisms, such as ADH, ALDH, and CYP4502E1, they will have a higher chance of developing alcoholic liver disease.
The first step in treating any level of alcoholic liver disease focuses on removing alcohol from the diet.
This can help to reverse some early stages of liver disease. For example, stopping drinking once diagnosed with fatty liver disease may be able to reverse the condition within
Once a doctor diagnoses a person with alcoholic liver disease at any stage, they will recommend them to never resume drinking. Any conditions that have reversed will typically return once drinking restarts.
Those who regularly drink more than the recommended daily limits of alcohol should not stop drinking without medical support. Withdrawal from alcohol can be life threatening. Individuals should seek help from a medical professional to safely manage alcohol withdrawal.
Cognitive behavioral therapy (CBT) and medications called benzodiazepines can ease withdrawal symptoms in a person with alcohol dependency. People with severe alcohol dependency may stay at an inpatient rehabilitation facility for closer monitoring.
Ongoing therapy may then be required to prevent a relapse into drinking alcohol. Medications can also prevent relapse, such as:
Doctors may also recommend weight loss and quitting smoking as excess weight and smoking have both
Other medications that show potential for treatment and are currently being studied include:
In people with liver failure, the liver completely ceases to function. This can be an outcome of advanced-stage liver disease and often means that a liver transplant is the
Typically, only people who can show at least
Antirejection medications after transplant can increase the risk of serious infections and certain cancers.
To prevent alcoholic liver disease and other conditions linked to the consumption of alcohol, doctors advise people to follow National Institute on Alcohol Abuse and Alcoholism (NIAAA) guidelines.
The guidelines classify
One drink is
- 12 fluid ounces (oz) of beer at 5% alcohol
- 5 oz of wine at 12% alcohol
- 1.5 oz of spirits at 40% alcohol
The NIAAA defines binge drinking as five or more alcoholic drinks for males or four or more alcoholic drinks for females on the same occasion, on at least 1 day in the past month.
The life expectancy of a person with alcoholic liver disease reduces dramatically as the condition progresses.
On average, 1 in 3 people with the most advanced stage of liver disease and cirrhosis are still alive after 2 years. When the body can compensate and manage cirrhosis, the typical lifespan is 6–12 years. Those with less severe diseases will survive longer if they abstain from alcohol.
Not smoking and controlling body weight are significant lifestyle changes people can make to further reduce the risk.