Premarin (conjugated estrogens) is a brand-name drug that’s prescribed for certain reproductive health conditions. It’s available as an oral tablet, injection, and vaginal cream. The cost of Premarin with and without insurance can depend on several factors.

Specifically, Premarin oral tablet is approved by the Food and Drug Administration (FDA) to:

Premarin intravenous (IV) or intramuscular (IM) injection is approved to treat short-term uterine bleeding that’s caused by hormone imbalance.

Premarin vaginal cream is approved to treat:

  • painful sex due to menopause
  • vaginal atrophy (dryness and inflammation of the vaginal wall)
  • kraurosis vulvae (shrinkage of vaginal and vulvar skin)

As with all medications, the cost of Premarin can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • the cost of the visit to your healthcare professional to receive doses of Premarin injection
  • whether Premarin has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Premarin will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Premarin prescription, explore these Optum Perks coupons.

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Save on Premarin without insurance.

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.625mg premarin (30 Tablets)

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Simply show the Optum Perks coupon at your preferred pharmacy or order online and instantly save up to 80% without using insurance. The coupon doesn’t expire, so be sure to save it for refills.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

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Premarin is only available as a brand-name drug. It doesn’t come in a generic version. A generic drug is an exact copy of the active ingredient in a brand-name medication.

Generics tend to cost less than brand-name drugs.


Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

Premarin injection is only intended for short-term use. However, if you use Premarin tablets or cream long term, you may be able to lower the cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Premarin. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

Using a mail-order pharmacy

Premarin may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for Premarin or help understanding your insurance coverage, help is available. For example:

  • The Premarin Co-Pay Card is available for Premarin oral tablets. For more information and to find out whether you’re eligible for support, call 866-410-3700 or visit the program website.
  • A savings card program is available for Premarin vaginal cream. For more information and to find out whether you’re eligible for support, call 866-879-4600 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Premarin.

What is the cost of Premarin without insurance?

The price you’ll pay for Premarin if you don’t have insurance can vary based on several factors. But typically, the cost is higher for those without insurance.

There are other factors that could affect what you pay for this drug. These include:

  • the quantity you’re prescribed (such as a 90-day or 30-day supply)
  • whether you apply and qualify for any available savings programs
  • your dosage
  • the pharmacy you use
  • the form of the drug you’re prescribed (the oral tablets, vaginal cream, or injection)

To learn the exact cost you’d pay for this medication without insurance, ask your doctor or pharmacist. You may also want to contact several pharmacies to compare their prices for Premarin.

Check out Optum Perks* for estimates of Premarin’s price when using coupons from the site. (Optum Perks coupons cannot be used with insurance benefits or copays.)

* Optum Perks is a sister site of Medical News Today.

Is Premarin covered by Medicare?

It may be. You can call your Medicare plan provider to learn whether your particular plan covers the cost of this drug. There are many types of Medicare plans, so your coverage and what you pay for prescriptions will be based on your particular plan’s benefits.

The total price you pay for Premarin injections may also depend on the cost of receiving doses at your doctor’s office or clinic. You may need to obtain prior authorization before your plan will cover the cost of this medication.

Your doctor may be able to provide information about your cost for Premarin if you have Medicare.

Below is information you may want to consider if you have insurance and receive Premarin.

Prior authorization: If you have insurance, your insurance company may require prior authorization before it covers Premarin. This means the company and your doctor will discuss Premarin in regard to your treatment. The insurance company will then determine whether the medication is covered.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Premarin requires prior authorization.

Type of insurance coverage: Premarin injections are given by your doctor or another healthcare professional. If you have insurance, the price of your Premarin injection may be billed through your medical coverage instead of the prescription drug portion of your insurance plan. This depends on your specific insurance plan and where you receive your Premarin injection, such as at your doctor’s office or a hospital.

If you have questions about this process, contact your doctor or your insurance provider.

Now that you’ve learned about cost and Premarin, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Premarin. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for Premarin.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.