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Zepbound (tirzepatide) is an injectable drug for weight loss in people with obesity or people with overweight and a weight-related condition. Here, we review our most trusted places to buy it online and in person.

Zepbound is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) drug. People inject the drug into their stomach, thigh, or upper arm.

The FDA approved Zepbound for weight loss in November 2023, making it a suitable alternative to Wegovy and Mounjaro.

According to the FDA, there is currently a shortage of tirzepatide, including Zepbound injections. Healthcare professionals may prescribe another GLP-1 medication that works in a similar way to encourage weight loss.

One alternative may be Wegovy, another FDA-approved drug for weight management. Read our recommendations on how to get Wegovy here.

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People can either get Zepbound by going to a healthcare professional in-person or using an online service. While getting Zepbound online may be more convenient than visiting a local clinic or surgery, both options require a valid prescription before a person can buy Zepbound at a pharmacy of their choice.

How to get Zepbound in-person

People must have a valid prescription from a doctor to get Zepbound. A doctor will assess a person’s current health, weight loss goals, and eligibility for the drug. They may prescribe it only if they think it is safe and medically necessary. A doctor may also discuss alternatives to Zepbound.

Once a person has a prescription for the drug, they can pick it up at their preferred pharmacy.

How to get Zepbound online

A person must still get a prescription to get Zepbound online, and they should not buy Zepbound from companies that do not require a health consultation with a qualified medical professional before offering a prescription.

The following table compares the three online pharmacy providers listed above.

Program costOther resourcesAccepts insurance
Ro Body• consultation: $99
• subscription: $145 per month
• health coaching
• weight loss program
yes
Plushcare• consultation: copay or $129
• subscription: $16.99 per month
• unlimited messaging
• discounts on lab tests
yes
Noom Med• consultation: $0
• subscription: $91 per month
• health coaching
• weight loss program
• food tracking app
no

Zepbound is for people who have:

Zepbound mimics the GIP and GLP-1 hormones that a person’s stomach releases when they eat. These hormones can slow down digestion and decrease a person’s appetite, eventually helping a person lose weight. However, people using Zepbound must also eat a reduced calorie diet and exercise regularly.

Learn more about how weight loss medications work.

Scientists have studied Zepbound’s active ingredient, tirzepatide, and found it effective for weight loss.

For instance, the authors of a 2023 meta-analysis of randomized controlled trials concluded that tirzepatide leads to significant weight loss. They mentioned that side effects such as nausea, vomiting, and diarrhea were common.

In a 72-week trial involving more than 2,500 people with obesity or overweight and related conditions, researchers found that tirzepatide in doses of 5, 10, and 15 milligrams (mg) resulted in significant and sustained weight loss. The study, which had support from the drug’s manufacturer, found that tirzepatide resulted in a mean total body fat mass reduction of 33.9%.

Citing this trial, Lilly reports an average weight loss of:

  • 34 pounds (lb) at the 5-mg dose
  • 44 lb at 10 mg
  • 48 lb at 15 mg

Costs for Zepbound will vary depending on a person’s health insurance and eligibility for certain savings schemes. Zepbound’s list price is $1,059.87 for a 1-month supply, but Lilly states that this does not reflect the price most people will pay for the drug.

We summarize the approximate costs in the table below.

Cost
Without insurancearound $1,000
Commercial insurance with Zepbound coverage$25 for a 1- or 3-month supply with a Zepbound Savings Card
Commercial insurance without Zepbound coverage$550 for a 1-month supply

To be eligible for the Zepbound Savings Card, people must:

  • have a valid prescription for Zepbound with FDA-approved product labeling
  • have coverage from a commercial drug insurance plan
  • not have enrollment in any state, federal, or government-funded healthcare program, including Medicare and Medicaid
  • be a resident of the United States or Puerto Rico
  • be at least 18 years old

The placebo group lost an average of 7 lb.

There are six Zepbound doses available:

  • 2.5 mg
  • 5 mg
  • 7.5 mg
  • 10 mg
  • 12.5 mg
  • 15 mg

A person typically takes one dose per week.

A doctor will recommend which dose a person should start with. Generally, a person will start on the lowest dose of 2.5 mg and gradually increase it if necessary.

According to the manufacturer, common side effects of Zepbound include:

In some cases, Zepbound may cause serious side effects, including:

Below, we answer some frequently asked questions about Zepbound.

According to Zepbound’s manufacturer, Lilly, the drug is now available in pharmacies with a valid prescription from a doctor.

The drug may not yet be available at all online pharmacies since the FDA approved it in November 2023.

Tirzepatide mimics the hormones GLP-1 and GIP, which a person’s stomach produces whenever they eat. These hormones reduce appetite, which can result in weight loss.

People must also follow a calorie-restricted diet and an exercise plan while using tirzepatide.

As of 2024, tirzepatide is available from pharmacies. However, the FDA reports that there may be shortages of certain branded tirzepatide products, such as Mounjaro.

Pharmacies may not always stock tirzepatide and may have to place a special order to fulfill a tirzepatide prescription. People can check ahead of time to see whether their pharmacy has the drug in stock.

People must have a prescription from a doctor to get tirzepatide.

Tirzepatide is FDA-approved for weight loss as the brand-name drug Zepbound.

It is also FDA-approved for type 2 diabetes management as the brand-name drug Mounjaro. Doctors can prescribe Mounjaro off-label for weight loss, but the drug does not have FDA approval for this use.

Zepbound is a new injectable weight loss drug for people who have obesity or have overweight and weight-related health conditions. It has FDA approval for weight loss, unlike its similar counterpart Mounjaro, which has approval only for type 2 diabetes management.

Research has shown that Zepbound’s active ingredient, tirzepatide, is very effective for weight loss.

People must have a prescription to get Zepbound. Without insurance, it can cost around $1,000 per month.

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