- Between 8–13% of reproductive-aged women worldwide have polycystic ovary syndrome (PCOS).
- There is no cure for PCOS, but treatment options exist for alleviating symptoms and lowering associated health risks.
- A recent study shows that women with PCOS who follow the ketogenic diet may experience improvements in fertility, weight loss, and lower testosterone levels.
The World Health Organization (WHO) estimates that
There is currently no cure for PCOS. Doctors utilize
In a recent study, researchers from the Ministry of Health Malaysia in Kuala Lumpur, Malaysia, have found evidence suggesting women with PCOS who follow the ketogenic diet may see improvements in fertility, weight loss, and lower testosterone levels.
This study was recently published in the Journal of the Endocrine Society.
Additionally, some women with PCOS will develop small cysts on their ovaries, also contributing to a hormone imbalance.
In addition to ovarian cysts, high androgen levels, irregular periods, and infertility, other symptoms of PCOS can include:
According to Dr. Karniza Khalid, a researcher at the Ministry of Health Malaysia in Kuala Lumpur, Malaysia, and lead author of this study, the effects of the keto diet on PCOS have been previously explored in clinical studies.
However, no systematic review has studied how the keto diet affects reproductive hormone levels.
“We decided to collate all the available evidence and synthesize the findings to allow for a robust conclusion and impact the clinical scene,” she told Medical News Today.
For the study, Dr. Khalid and her team analyzed data from seven clinical trials evaluating the effects of the keto diet in women with PCOS.
Scientists found women with PCOS who followed the keto diet for at least 45 days experienced significant weight loss, improved reproductive hormone levels, and lowered testosterone levels.
“PCOS is a complex hormonal condition —
hyperandrogenismand reduced insulin sensitivity being one of the hallmark endocrinological features. Induction of physiological ketosis from keto diet will reduce the circulating insulin level and IGF-1, further suppressing the stimulus for adrenal and ovarian androgen production, hence limiting the level of circulating free androgen in the blood.”
— Dr. Karniza Khalid, lead study author
When a person eats carbohydrates, their digestive system breaks it down into sugar called glucose.
If a person who is insulin resistant eats carbohydrates, the insulin the pancreas makes is not working properly. This ends up causing too much glucose to remain in the body’s bloodstream and the cells do not get the energy they need.
Previous studies have found that females with PCOS who follow a low carb diet may see improvements in:
- insulin resistance
- testosterone levels
- weight loss and body mass index (BMI)
There are a variety of low carb diets, with the keto diet being one of the most well-known.
This is not the first study to examine the keto diet’s effect on PCOS. A study in February 2020 found the keto diet to be a “
Additionally, previous studies suggest low carb diets may help with PCOS-related infertility issues. A study published in November 2021 found a low carb diet to be an “
Another study in October 2022 found a very low calorie keto diet may help
The exact cause of PCOS is still unknown, but previous research shows risk factors for the condition may include:
Additionally, as insulin is the hormone responsible for telling the body when to store fat, high levels lead to
MNT also discussed this study with Dr. G. Thomas Ruiz, OB-GYN lead at MemorialCare Orange Coast Medical Center in Fountain Valley, CA.
Dr. Ruiz said he was not surprised by this study’s findings because insulin resistance is common with PCOS.
“I have been telling my patients to go on low carb diets for years,” Dr. Ruiz continued. “My preference is the Mediterranean diet, (but) I have a preference for any diet which is low carb where you do not see increased insulin secretion.”
“One of the hallmarks of the keto diet is high fat, high protein, but almost no carbs — a limited number of carbs. And it’s the simple carbs that create high glucose levels. If you can control their insulin levels and get them to drop, (women with PCOS) actually may start to ovulate spontaneously and start to reverse changes that occur because of
hyperinsulinemia, including decreasing testosterone levels.”
— Dr. G. Thomas Ruiz, OB-GYN
“(A) few parameters should come into play when planning: age, baseline BMI, gender, baseline health status — (the) presence of kidney and liver impairments — and gut health,” Dr. Khalid noted.