L-tryptophan is an essential amino acid that performs many functions in the body, including the production of serotonin. Serotonin is a chemical in the brain that affects mood.
Although some evidence suggests that L-tryptophan may help with certain conditions, such as anxiety or sleep disorders, additional research is necessary to prove whether or not taking L-tryptophan supplements is effective.
This article examines the safety and efficacy of L-tryptophan supplements.
L-tryptophan, or tryptophan, is an essential amino acid that plays a part in creating serotonin. Serotonin is a hormone present in various parts of the body, including the brain. The serotonin in the brain helps regulate a person’s mood, anxiety, and levels of happiness.
L-tryptophan is also available as a supplement.
Because L-tryptophan plays a role in the production of serotonin in the brain, some experts suspect that it may help with conditions such as anxiety and sleep disorders. There is some evidence to support its use for these purposes.
In humans, the authors noted that those most likely affected are people with risk factors for developing depression. It is possible that at risk populations may benefit from increased tryptophan levels.
However, they did note that L-tryptophan was effective in helping the participants sleep during the detox process. The researchers also noted that additional studies are necessary to prove how effective it may actually be.
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L-tryptophan is safe when a person consumes it as part of their regular diet. When consuming it in supplement form, a person may experience minor side effects.
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- sleepiness (in those not taking it for sleep disorders)
Although this is not common, a person may experience serotonin syndrome if they take multiple medications for depression or anxiety at the same time.
Though rare, serotonin syndrome is most likely to occur when a person takes an L-tryptophan supplement with medications that alter serotonin levels, such as antidepressants.
Symptoms of serotonin syndrome may include:
- involuntary twitching or jerking
It is also important to note that the Food and Drug Administration (FDA) do not currently regulate supplements.
However, there are several different independent testing agencies that do look at supplements for purity and potency. People should look for supplements that have certification from third party evaluators to help minimize their risk of exposure to bad products or ineffectiveness.
L-tryptophan is naturally present in many foods. Some food sources include:
It is not likely that the amount of the nutrient present in food will have any positive or negative effects on a person’s sleep or mood.
Melatonin is another supplement that people may use to help ease insomnia or sleep disorders. Melatonin is a hormone that the body releases to stimulate sleep in the evening and waking in the morning.
A person can also try non-supplement-related sleep aids. Some steps that may help facilitate a better night of sleep include:
- drinking warm milk
- ensuring that the bedroom is cool and dark
- exercising during the day
People should talk to their doctor if they have other conditions that they were considering using L-tryptophan for to get advice on possible treatments.
People should talk to their doctor before starting any supplement. In particular, people who take antidepressants should talk to their doctor before taking L-tryptophan supplements.
People should stop taking the supplement and talk to their doctor if they notice any unusual symptoms after taking it.
L-tryptophan may be an effective sleep aid and may also help with other conditions, such as chronic pain, anxiety, depression, or PMS.
However, the supplement may not be for everyone, and it may not be helpful for all conditions. People should talk to their doctor before starting a new supplement, and they should stop using it if they experience any side effects.
More research is necessary to determine whether or not L-tryptophan is safe and effective in easing any of these conditions.