Uterine cancer and fibroids are both conditions that can affect the uterus. Uterine cancer is a type of cancer that begins in the lining of the uterus, while fibroids are noncancerous tumors that grow in the uterine walls.

Uterine cancer is the most common type of gynecologic cancer in the United States. It usually occurs in people who are postmenopausal or in their 50s or 60s, although it can occur at any age.

Fibroids, also called uterine leiomyomas, are noncancerous tumors that develop in or on the muscular walls of the uterus. They commonly occur in people of childbearing age and can vary in size from small, pea-sized growths to large tumors that can distort the shape of the uterus.

This article discusses the differences between uterine cancer and fibroids in terms of their clinical features, symptoms, diagnostic methods, treatments, and outlook. It also answers some frequently asked questions.

The main difference between uterine cancer and fibroids is that uterine cancer involves the development of a cancerous tumor, while fibroids are noncancerous tumors.

This means uterine cancer cells can spread to other parts of the body, while fibroids cannot.

Symptoms

Symptoms may also differ between the two conditions.

Uterine cancer may cause:

Fibroids more commonly cause:

The age at which these conditions typically occur can also be a distinguishing factor. Uterine cancer typically occurs in postmenopausal people in their 50s or 60s, while fibroids occur in people of childbearing age.

Clinical features

Additional clinical characteristics may help differentiate between uterine cancer and fibroids.

For example, uterine cancer primarily involves the lining of the uterus and muscles, while fibroids develop within the muscular walls of the uterus.

Uterine cancer tumors also tend to grow rapidly and can become large unless a person has a low grade cancer. On the other hand, fibroids may remain small for a prolonged period. They may grow suddenly and rapidly or slowly over several years.

According to research from 2018, the following percentages of people with uterine cancer or fibroids presented with the symptoms below:

SymptomUterine cancerFibroids
Pain or pressure43.9%51.5%
Heavy menstrual bleeding13.6%68.2%
Postmenopausal bleeding54.6%3.0%

Consistent with previous studies, the researchers found no significant differences in the number of people who experienced pain or pressure. However, bleeding symptoms tended to differ between people with uterine cancer versus those with fibroids.

Doctors use different methods for diagnosing each condition.

Uterine cancer

Doctors may use various diagnostic methods to determine if a person has uterine cancer, including:

If a doctor suspects that cancer has spread elsewhere in the body, additional tests may take place, such as the following scans:

Learn more about testing for uterine cancer.

Fibroids

Doctors may use similar diagnostic methods to determine if a person has fibroids, including:

  • ultrasound
  • MRI or CT imaging
  • hysteroscopy

They may also use the following:

  • laparoscopy to examine the pelvis
  • hysterosalpingography to assess the size and shape of the uterus
  • sonohysterography, which involves inserting fluid to obtain clear imaging of the uterus

Treatment options for the two conditions will differ.

Uterine cancer

The treatment a doctor recommends for uterine cancer will depend on the stage of the cancer.

Doctors may recommend a hysterectomy for early stage cancer. More advanced cancer may require a combination of the following:

Find out more about treatments for uterine cancer.

Fibroids

Doctors will also choose treatments for fibroids based on the symptoms a person is experiencing.

They may use medications, including:

Some people may require surgery to remove the fibroids, such as a myomectomy or hysterectomy.

Learn more about treating fibroid pain.

The outlook for a person with each condition may vary.

Uterine cancer

The outlook for individuals with uterine cancer generally depends on the stage of the cancer at diagnosis. Early stage cancer is very curable, with a 5-year survival rate of over 90%. The 5-year survival rate for advanced-stage cancer is much lower.

However, everyone’s cancer is unique, and many factors can affect it. Ultimately, an outlook is only an educated guess.

Read more about the outlook for people with uterine cancer.

Fibroids

Fibroids do not increase the risk of cancer, and they usually do not cause long-term health problems. However, they may cause discomfort, such as during periods, and may cause some complications with pregnancies.

Below are the answers to some common questions about uterine cancer and fibroids.

Can uterine cancer be mistaken for a fibroid?

Yes, medical professionals may sometimes mistake uterine cancer for a fibroid due to similar symptoms, such as atypical bleeding and pelvic pain.

It is important for a person to speak with a doctor to determine their diagnosis and receive suitable treatment.

Can you tell the difference between a fibroid and cancer on an ultrasound?

While ultrasound scans can help in the diagnosis of both fibroids and uterine cancer, they cannot definitively differentiate between the two.

Additional diagnostic measures may be necessary to make a definitive diagnosis. This may include biopsies or imaging tests such as CT or MRI scans.

What are the first signs of uterine cancer?

One of the first signs of uterine cancer is atypical vaginal bleeding, especially after menopause. This includes:

According to the American Cancer Society, about 90% of people with uterine cancer have atypical vaginal bleeding.

Women’s health resources

Visit our dedicated hub for more research-backed information and in-depth resources on women’s health.

Was this helpful?

Uterine cancer and fibroids are two common conditions that can affect the uterus. While they can both lead to symptoms such as heavy menstrual bleeding and pelvic pain, they are very different in terms of their causes, levels of severity, and treatment.

People experiencing symptoms such as heavy menstrual bleeding or pelvic pain should consult a healthcare professional to determine the cause and receive an appropriate diagnosis and treatment.

To differentiate between uterine cancer and fibroids, medical professionals may need to use diagnostic tools such as biopsies or imaging tests such as CT or MRI scans.