New Species Found That Causes Leptospirosis

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Main Category: Infectious Diseases / Bacteria / Viruses
Also Included In: Public Health;  Water - Air Quality / Agriculture
Article Date: 03 Apr 2008 - 0:00 PDT

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Leptospirosis is an acute infectious disease caused by bacterial spriochetes of the genus Leptospira. An article published in the open-access journal PLoS Neglected Tropical Diseases reports that a new species of Leptospira has been identified in the highly biodiverse Peruvian Amazon region. Researcher Michael A. Matthias (Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine) and colleagues found that the domestic rat is the animal source of this species, and they demonstrated how the disease was identified in patients in Iquitos, Peru by modifying the diagnostic routines to include the new species.

Leptospirosis is especially common in low-income areas with poor sanitation and contaminated water. The Amazon region of Iquitos, with its diverse animal population, tropical weather, and lack of sufficient sanitation, is a model ecological setting for maintaining and transmitting leptospirosis. Although the infectious disease has become globally important (not isolated to the Amazon), the difficulties involved in its diagnosis interfere with the ability to gage the precise public health impact.

The researchers provisionally named the new species Leptospira licerasiae after isolating and identifying it. They then included the new isolate when testing the blood of patients with acute febrile illness (fever fits) in Iquitos, Peru. Finding a much higher incidence of leptospirosis than expected, the authors demonstrate the importance of diagnosing with region-specific Leptospira.

The authors conclude: "Based on serological data that take advantage of its antigenic uniqueness, 'Leptospira licerasiae' serovar Varillal appears to be an important cause of leptospirosis in the Peruvian Amazon region, but is uncommon elsewhere in Peru. The peridomestic rat is likely the major reservoir of this new species. Elucidation of virulence differences between pathogenic and intermediate leptospires will provide insight into leptospiral evolution and disease mechanisms, and may contribute to the control and amelioration of leptospirosis in the developing world."

Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian Amazon
Matthias MA, Ricaldi JN, Cespedes M, Diaz MM, Galloway RL, et al.
PLoS Neglected Tropical Disease (2008). 2(4): e213.
doi:10.1371/journal.pntd.0000213
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PLoS Neglected Tropical Diseases (http://www.plosntds.org/) is a peer-reviewed, open-access journal devoted to the pathology, epidemiology, prevention, treatment, and control of the neglected tropical diseases, as well as public policy relevant to this group of diseases. All works published in PLoS Neglected Tropical Diseases are open access, which means that everything is immediately and freely available subject only to the condition that the original authorship and source are properly attributed. The Public Library of Science uses the Creative Commons Attribution License, and copyright is retained by the authors.

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Written by: Peter M Crosta
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