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"Palbociclib is an investigational, oral and selective inhibitor of cyclin dependent kinases (CDK) 4 and 6. CDK 4 and 6 are two closely related kinases that enable tumor cell progression during phase G1 to phase S in the cell cycle. This progression is necessary for DNA replication and cell division."The company said:
"We appreciate the opportunity that Breakthrough Therapy designation provides to work closely with the FDA on the development of palbociclib."
"We appreciate the opportunity that Breakthrough Therapy designation provides to work closely with the FDA on the development of palbociclib. Palbociclib is one example of Pfizer's commitment to identifying and translating innovative science into meaningful new treatment options for cancer patients."
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Nordqvist, Joseph. "FDA Step Closer To Approving Breast Cancer Drug "Palbociclib"." Medical News Today. MediLexicon, Intl., 11 Apr. 2013. Web.
6 Dec. 2013. <http://www.medicalnewstoday.com/articles/258934>
Nordqvist, J. (2013, April 11). "FDA Step Closer To Approving Breast Cancer Drug "Palbociclib"." Medical News Today. Retrieved from
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