Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
As most people resolve themselves to lose weight this New Year, here's why it seems to get easier and easier to pack on unwanted pounds: New research published in the January 2014 issue of The FASEB Journal, shows that as we age, the thermogenic activity of brown fat is reduced. Brown fat is a "good" fat located in the backs of our necks that helps burn "bad" white fat around our bellies. Additionally, the researchers also discovered a possible metabolic on/off switch that could reactivate brown fat.
"Future studies on how PAF/PAFR signaling controls UCP1 levels through beta3-AR production in the BAT of animals and humans may reveal new therapeutic targets to treat metabolic disorders associated with obesity," said Junko Sugatani, Ph.D., a researcher involved in the work from the Department of Pharmaco-Biochemistry at the School of Pharmaceutical Sciences at the University of Shizuoka in Shizuoka, Japan.
To make this discovery, scientists analyzed two groups of mice. The first group had the platelet-activating factor receptors (PAFR) gene knocked out. The second group was normal. PAFR-deficient mice developed a more severe obese state characterized by higher body and epididymal fat mass with age than that of wild-type littermates. Findings from the PAFR-KO genetic model reveal that PAFR-deficiency causes brown adipose tissue (BAT) dysfunction, which converges to induce the development of obesity, due to impaired thermogenic activity of BAT. This study could elucidate the molecular mechanism underlying the PAF/PAF receptor-mediated anti-obesity, leading to the development of new targets for the treatment of obesity and related disorders, such as diabetes, high blood pressure, heart disease, cancer, infertility and ulcers.
"A common complaint is that older people have to work twice as hard with their diets and exercise to get half of the results of younger people," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Now we have a much better idea why this is the case: Our brown fat stops working as we age. Unfortunately, until a way to turn it back on is developed, we'll have to be prepared to eat more salads and lean proteins, while logging more miles on the treadmill than our younger counterparts."
Details: Junko Sugatani, Satoshi Sadamitsu, Masahiko Yamaguchi, Yasuhiro Yamazaki, Ryoko Higa, Yoshiki Hattori, Takahiro Uchida, Akira Ikari, Wataru Sugiyama, Tatsuo Watanabe, Satoshi Ishii, Masao Miwa, and Takao Shimizu. Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. FASEB J January 2014 28:440-452; doi:10.1096/fj.13-233262 ;
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Obesity / Weight Loss / Fitness category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
FASEB. "Scientists explain age-related obesity: Brown fat fails." Medical News Today. MediLexicon, Intl., 6 Jan. 2014. Web.
10 Mar. 2014. <http://www.medicalnewstoday.com/releases/270782>
FASEB. (2014, January 6). "Scientists explain age-related obesity: Brown fat fails." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/270782.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.