Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Malaria is one of the most deadly infectious diseases in the world today, claiming the lives of over half a million people every year, and the recent emergence of parasites resistant to current treatments threatens to undermine efforts to control the disease. Researchers are now onto a new strategy to defeat drug-resistant strains of the parasite. Their report appears in the journal ACS Chemical Biology.
Christine Hrycyna, Rowena Martin, Jean Chmielewski and colleagues point out that the parasite Plasmodium falciparum, which causes the most severe form of malaria, is found in nearly 100 countries that, all totaled, are home to about half of the world's population. Every day, P. falciparum and its relatives hitch rides via mosquitoes to find a human home. An effective vaccine remains elusive and the continuing emergence of drug-resistant parasites is cause for alarm. The good news is that these scientists have designed compounds that work against P. falciparum strains that are resistant to drugs such as chloroquine. The team wanted to understand how these compounds worked and to develop new candidate antimalarials.
In the lab, the scientists designed and tested a set of molecules called quinine dimers, which were effective against sensitive parasites, and, surprisingly, even more effective against resistant ones. The compounds have an additional killing effect on the drug-resistant parasites because the compounds bind to and block the resistance-conferring protein. This resensitizes the parasites to chloroquine, and appears to block the normal function of the resistance protein, killing the parasite. "This highlights the potential for devising new antimalarial therapies that exploit inherent weaknesses in a key resistance mechanism of P. falciparum," they state.
The authors acknowledge funding from the Bill & Melinda Gates Foundation and the Australian National
Quinine Dimers Are Potent Inhibitors of the Plasmodium falciparum Chloroquine Resistance Transporter and Are Active against Quinoline-Resistant P. falciparum, Christine A. Hrycyna, Robert L. Summers, Adele M. Lehane, Marcos M. Pires, Hilda Namanja, Kelsey Bohn, Jerrin Kuriakose, Michael Ferdig, Philipp P. Henrich, David A. Fidock , Kiaran Kirk, Jean Chmielewski, and Rowena E. Martin, ACS Chem. Biol., - DOI: 10.1021/cb4008953
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Tropical Diseases category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
American Chemical Society. "New candidate antimalarials for fighting drug-resistant malaria." Medical News Today. MediLexicon, Intl., 18 Jan. 2014. Web.
18 Apr. 2014. <http://www.medicalnewstoday.com/releases/271307>
American Chemical Society. (2014, January 18). "New candidate antimalarials for fighting drug-resistant malaria." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/271307.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.