Ankylosing spondylitis is a type of arthritis that causes chronic pain and discomfort, usually in the spine.

It is important to understand the early signs and symptoms of ankylosing spondylitis and how the condition progresses. This can help people know when they should contact a doctor and what to expect from their diagnosis and treatment.

This article aims to provide a guide to how ankylosing spondylitis affects the body and how doctors diagnose the condition.

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Ankylosing spondylitis is a type of arthritis that causes inflammation in the spinal joints. In some cases, it can affect the joints of the hips, shoulders, ribs, heels, and hands. It can also impact the eyes.

This condition can progress differently for every person who has it. The symptoms usually appear during adolescence or a person’s early 20s, but they can sometimes begin in childhood.

Symptoms can include:

  • gradually evolving dull pain or stiffness in the lower back or buttocks that becomes chronic and lasts for longer than 3 months
  • pain that is worse in the morning and at night and interferes with sleep
  • low-grade fevers, a loss of appetite, and general discomfort, especially during the early stages of the condition
  • pain that eventually spreads to the ribs, shoulders, thighs, hips, or heels
  • fatigue
  • enthesitis, which refers to inflammation at a specific site where ligament connects to bone
  • bowel inflammation that may be associated with conditions such as Crohn’s disease or ulcerative colitis
  • uveitis, or inflammation in the eyes

Some people develop more serious complications. For example, advanced ankylosing spondylitis can cause urinary retention, incontinence, and a loss of bowel control.

The condition is also associated with aortitis. This causes inflammation of the aorta, which is the large artery that exits the heart.

Ankylosing spondylitis can also lead to lung scarring.

There is no single test to diagnose ankylosing spondylitis. Doctors often use X-rays, CT scans, and MRI scans to find evidence of inflammation in key areas, such as the joint between the sacrum and the ilium.

Doctors also need to gather information about the type of back pain a person is experiencing. People with ankylosing spondylitis usually have symptoms before the age of 45 years, and their symptoms typically develop gradually over a period of 3 months or more.

People with ankylosing spondylitis also tend to experience back pain that gets worse while they sleep and starts to feel better once they move or take a warm bath or shower. The pain associated with ankylosing spondylitis does not usually improve with resting but tends to get better with exercise and physical motion.

Doctors often ask people if these situations apply to them and then move on to imaging to determine whether or not it is ankylosing spondylitis causing the symptoms.

There is also a blood test that looks for a gene called HLA-B27. Although having this gene does not mean that someone will definitely develop ankylosing spondylitis, it does appear in many cases.

Anyone who is experiencing symptoms that may be linked to ankylosing spondylitis may benefit from visiting a doctor. The doctor may run the tests or refer the individual to a rheumatologist for testing.

People who have received a diagnosis of ankylosing spondylitis, including those with minor symptoms that are manageable at home, should continue to see a rheumatologist at least once per year. Attending these checkups allows the rheumatologist to track the progression of the condition and to monitor for complications that may not be causing any symptoms.

Treatment for ankylosing spondylitis involves many different approaches designed to make the symptoms manageable. A typical treatment plan includes physical approaches such as exercise and physical therapy.

A person may also be able to help treat the pain using nonsteroidal anti-inflammatory drugs (NSAIDs). Research suggests that NSAIDs may benefit people with ankylosing spondylitis because these medications can reduce the inflammation that causes the symptoms.

A doctor can also prescribe tumor necrosis factor inhibitors, which are drugs that inhibit a protein that plays a key role in the symptoms of ankylosing spondylitis.

Some people may also benefit from steroid injections.

In severe cases, a person may need surgery.

Since ankylosing spondylitis affects everyone differently, the outlook for people with the condition varies. Those with mild ankylosing spondylitis can expect to be able to continue functioning normally, while others may experience severe disability without effective treatment.

When ankylosing spondylitis causes life threatening complications such as inflammation in the heart, it may negatively affect a person’s life expectancy.

About 1% of people with ankylosing spondylitis experience remission.

Ankylosing spondylitis is a type of arthritis that affects the spinal joints. It primarily causes pain and stiffness throughout the body, but it can also affect other body parts and organs.

It is important for people with ankylosing spondylitis to follow their treatment plan and to contact a doctor or rheumatologist regularly to check on the progression of any symptoms. Doing so provides the best chance of managing the symptoms and slowing the progression of the condition.