Acute myeloid leukemia (AML) is a cancer of the bone marrow and blood that results in the production of abnormal blood cells. Both modifiable and non-modifiable risk factors exist that can increase the chance of a person developing AML.
Some people may refer to AML by other names, such as acute myelocytic leukemia, acute myelogenous leukemia, acute granulocytic leukemia, and acute nonlymphocytic leukemia. The causes of AML are still unknown. However, scientists believe that it results from abnormalities in one or several genes that normally control blood cell production and growth.
In this article, we will discuss potential risk factors that may increase the likelihood of developing AML.
AML can happen at any age. However, it is more common in adults aged 60 and above, with AML having a median age of 70 years old. With increasing age, people are
Smoking is a known risk factor for several types of cancer. Not only does it affect cells that come in direct contact with smoke, causing lung and mouth cancers, but cancer-causing substances absorbed by the lungs can also spread through the bloodstream and reach other parts of the body.
A 2014 study found that current smokers have a
Exposure to certain chemicals, like benzene, also increases a person’s risk of AML. According to the Centers for Disease Control and Prevention (CDC), benzene is a commonly used industrial chemical in the United States. that is present in cigarette smoke, rubbers, dyes, and pesticides. Evidence indicates that long-term exposure can cause leukemia.
Benzene is known to alter cell function and induce blood cancers. A 2020 study found that benzene exposure has a 7-fold risk for developing leukemia and benzene poisoning has a 71-fold risk of causing AML. Researchers also found that prolonged benzene exposure led to a rapid leukemic mutation of cells in mice.
Many individuals with other cancers, such as solid tumors, who receive treatment with certain chemotherapy drugs, like
People who have chemotherapy are also at risk of having clonal hematopoiesis, an age-related disease that can cause an overproduction of blood precursor cells.
Exposure to high doses of radiation, including radiation therapy for cancer, increases a person’s risk of AML.
A 2020 study states that radiation exposure causes gene abnormalities similar to alkylating agents, most commonly in chromosomes 5 and 7. The study also notes that people who acquire therapy-related cancers from radiation exposure have poorer outcomes, despite intensive treatments.
Other conditions, especially
The 2016 World Health Organization (WHO) classification of myeloid and acute leukemia recognizes AML as a condition with a hereditary predisposition. A person with a twin, sibling, or parents with AML has an increased chance of developing the condition.
Several genetic conditions may also
- Down syndrome
- trisomy 8
- Fanconi anemia
- Bloom syndrome
- ataxia-telangiectasia (AT)
- neurofibromatosis type 1
- Kostmann syndrome, also called severe congenital neutropenia
- Diamond-Blackfan anemia
- Shwachman-Diamond syndrome
- Li-Fraumeni syndrome
Obesity is a known risk factor linked with many cancers, including blood cancers. This is because obesity creates a cellular environment that
Researchers continue to investigate other possible factors that may link to AML. While there are already several studies available, there is not yet sufficient evidence to suggest the factors studied may cause AML.
A 2017 study found that children who live near gasoline stations and have parents exposed to benzene are more likely to develop childhood leukemia. Both associations relate to the benzene content of these chemicals.
Pesticide exposure is also associated with childhood leukemia, especially AML.
AML is a bone marrow and blood cancer. While the exact cause of AML is unknown, evidence suggests there are multiple factors that can cause genetic changes and increase a person’s risk of developing AML. There are some risk factors that people cannot change, such as age and family history. However, people can try to reduce other risk factors, such as exposure to smoking and certain chemicals.