Jesduvroq is a brand-name oral tablet that’s prescribed for anemia caused by chronic kidney disease. Jesduvroq contains the active drug daprodustat.
You’ll find key information about Jesduvroq below.
- Drug class: hypoxia-inducible factor prolyl hydroxylase inhibitor
- Drug form: oral tablet
- Generic available? no
- Prescription required? yes
- Controlled substance? no
- Year of FDA approval: 2023
The Jesduvroq dosage your doctor prescribes will depend on several factors. These include:
- the level of hemoglobin (Hgb) in your blood
- other medical conditions you may have
- other medications you may be taking and your current dosage of those medications
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
Drug forms and strengths
Jesduvroq comes as an oral tablet. It’s available in five strengths:
- 1 milligram (mg)
- 2 mg
- 4 mg
- 6 mg
- 8 mg
Dosage for anemia caused by chronic kidney disease
Jesduvroq is prescribed to treat anemia caused by chronic kidney disease in certain adults. The starting dosage depends on whether you’re already taking an erythropoietin-stimulating agent (ESA). Examples of ESAs include epoetin alfa (Procrit), darbepoetin alfa (Aranesp), and methoxy polyethylene glycol-epoetin beta (Mircera).
Dosage for adults not taking an ESA
If you’re not already taking an ESA, your starting Jesduvroq dosage depends on the level of Hgb in your blood. Hgb levels are measured in grams per deciliter (g/dL).
- if your Hgb is less than 9 g/dL, you’ll take 4 mg of Jesduvroq once per day
- if your Hgb is 9–10 g/dL, you’ll take 2 mg of Jesduvroq once per day
- if your Hgb is greater than 10 g/dL, you’ll take 1 mg of Jesduvroq once per day
Your doctor may give you a different starting dosage depending on certain factors, including whether you have liver disease. Your doctor will recommend the starting dosage that’s right for you.
Your doctor will check your Hgb levels regularly during Jesduvroq treatment and adjust your dosage as needed. The maximum recommended dosage of Jesduvroq is 24 mg once per day.
If your doctor doesn’t see a meaningful change in Hgb levels after 6 months, they may stop Jesduvroq treatment and recommend other options.
Dosage for adults switching from an ESA
If you’re switching from an ESA, your starting Jesduvroq dosage depends on the ESA dosage you were prescribed. The typical starting range is 4-12 mg of Jesduvroq once per day. However, your doctor may give you a different starting dosage depending on certain factors, including whether you have liver disease. Your doctor will recommend the starting dosage that’s right for you.
Your doctor will adjust your Jesduvroq dosage over time based on your hemoglobin (Hgb) levels. The maximum recommended dosage of Jesduvroq is 24 mg once per day.
If your doctor doesn’t see a meaningful change in Hgb levels after 24 weeks, they may stop Jesduvroq treatment and recommend other options.
About taking Jesduvroq
Below you’ll find information about key dosage issues.
- When to take. You should take Jesduvroq once a day. Taking the medication around the same time of day helps keep a steady level of the drug in your body. This helps Jesduvroq work effectively.
- If you miss a dose. If it’s the same day as your missed dose, take it as soon as you remember. If it’s not the same day as your missed dose, skip it. Then take your next dose again at the regular time. If you aren’t sure whether to take or skip a missed dose, talk with your doctor or pharmacist.
- Taking Jesduvroq with food. You can take each dose of Jesduvroq with or without food.
- Crushing, splitting, or chewing Jesduvroq. You’ll swallow the tablets whole. Jesduvroq tablets should not be crushed, split, or chewed. If you have trouble swallowing tablets, talk with your doctor or pharmacist. You can also refer to this article for tips.
- Length of use. Jesduvroq is meant to be used as a long-term treatment. If you and your doctor determine that Jesduvroq is safe and effective for you, you’ll likely take it long term.
Taking more than the recommended dosage of Jesduvroq can lead to serious side effects. Do not take more Jesduvroq than your doctor recommends.
Symptoms of an overdose can include headache and digestive symptoms, such as nausea.
What to do in case of overdose
If you think you’ve taken too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.
Jesduvroq can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Jesduvroq. These lists do not include all possible side effects.
For more information about the possible side effects of Jesduvroq, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.
Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Jesduvroq, you can do so through MedWatch.
Mild side effects
Below is a partial list of mild side effects of Jesduvroq. To learn about other mild side effects, talk with your doctor or pharmacist, or view Jesduvroq’s prescribing information.
Mild side effects of Jesduvroq can include:
- abdominal pain
- mild allergic reaction*
Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.
* For more information about allergic reaction and Jesduvroq, see “Allergic reaction” below.
Serious side effects
Certain serious side effects from Jesduvroq are more common than others. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Serious side effects and their symptoms can include:
- Damage to the lining of your esophagus, stomach, or intestines. Symptoms can include:
- bloody vomit or stool
- throat pain
- abdominal pain
- Cancer. Symptoms can vary depending on the type of cancer but may include:
- bruising or bleeding more easily than usual
- unintentional weight loss
- Heart failure that needs treatment in a hospital. Symptoms can include:
- shortness of breath
- swelling in your legs, ankles, or feet
- High blood pressure, which doesn’t typically cause symptoms unless it’s severe. Symptoms of severely high blood pressure can include:
- Increased risk of death and serious cardiovascular problems.*
- Severe allergic reaction.†
* Jesduvroq has a boxed warning for this side effect. This is the most serious warning from the FDA. To learn more, see the “Jesduvroq precautions” section below.
† For details about allergic reaction and Jesduvroq, see “Allergic reaction” below.
Symptoms of a mild allergic reaction can include:
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have an allergic reaction to Jesduvroq, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
The Food and Drug Administration (FDA) approves prescription drugs such as Jesduvroq to treat certain conditions.
Jesduvroq for anemia caused by chronic kidney disease
With CKD, your kidneys don’t work as well as they should. As a result, your kidneys make less erythropoietin. This is a hormone that helps your body make red blood cells. Having low erythropoietin can lead to anemia.
Doctors typically won’t prescribe Jesduvroq in certain situations, such as:
- to ease fatigue or improve quality of life, including your emotional well-being or ability to perform daily tasks
- for people who are not receiving dialysis
- instead of blood cell transfusions for people who need their anemia treated right away
Jesduvroq and children
Jesduvroq is not approved for use in children. It’s not known whether the drug is safe or effective for children.
Before taking Jesduvroq, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
Interactions with medications
Below is a list of medications that can interact with Jesduvroq. This list does not contain all drugs that may interact with Jesduvroq. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
|Medications that can interact with Jesduvroq
|• gemfibrozil (Lopid)
• clopidogrel (Plavix)
• rifampin (Rifadin, Rimactane)
• trimethoprim or sulfamethoxazole/trimethoprim (Bactrim, Septra, others)
• nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin) and naproxen (Aleve)
Alcohol is not known to interact with Jesduvroq.
However, it may not be safe to consume alcohol while taking Jesduvroq. Both alcohol and Jesduvroq may cause damage to the lining of your esophagus, stomach, or intestines when used individually. Consuming alcohol during Jesduvroq treatment increases this risk even further.
If you have questions about the safety of drinking alcohol while taking Jesduvroq, talk with your doctor or pharmacist.
As with all medications, the cost of Jesduvroq can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.
Financial and insurance assistance. If you need financial support to pay for Jesduvroq, or if you need help understanding your insurance coverage, help is available.
To learn more about saving money on prescriptions, check out this article.
Generic version. Jesduvroq is not available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.
Other drugs are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Jesduvroq, talk with your doctor. They can tell you about other medications that may work well for you.
Erythropoietin-stimulating agents are alternatives to Jesduroq. Examples of these medications include:
- epoetin alfa (Procrit)
- darbepoetin alfa (Aranesp)
- methoxy polyethylene glycol-epoetin beta (Mircera)
If you can become pregnant, consider the following information about pregnancy and breastfeeding.
Jesduvroq and pregnancy
It’s not known whether Jesduvroq should be taken during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before taking this medication.
Jesduvroq and breastfeeding
Jesduvroq should not be taken while breastfeeding. It isn’t known for certain whether the drug passes into breast milk or causes side effects in a child who’s breastfed. To be safe, you should avoid breastfeeding during Jesduvroq treatment and for at least 1 week after your last dose.
If you’re currently breastfeeding or planning to do so, talk with your doctor before taking this medication. Your doctor can recommend other ways to feed your child during treatment with Jesduvroq.
Here are answers to some frequently asked questions about Jesduvroq.
How does Jesduvroq work?
Jesduvroq is used to treat anemia caused by chronic kidney disease (CKD) in certain adults. Having CKD may cause your kidneys to make less erythropoietin, which is a hormone that helps your body make red blood cells. Low levels of this hormone can lead to anemia.
Jesduvroq works by helping your body make more erythropoietin. As a result, your body is able to make more red blood cells. In this way, Jesduvroq works to treat anemia caused by CKD.
If you have other questions about how Jesduvroq works, talk with your doctor or pharmacist.
Does Jesduvroq cause long-term side effects?
It’s possible. Jesduvroq may cause side effects that start during treatment and lead to long-term problems even after treatment ends.
For example, Jesduvroq may cause damage to the lining of your esophagus, stomach, or intestines. Other possible long-term side effects include:
- heart failure that needs treatment in a hospital
- high blood pressure
- increased risk of death and serious cardiovascular problems*
If you have other questions about long-term side effects with Jesduvroq, talk with your doctor or pharmacist.
Is it safe to take Jesduvroq with an iron supplement?
Yes, if your doctor recommends it.
Jesduvroq is prescribed to treat anemia caused by CKD in certain adults. People with this condition may have low iron levels in their blood. For this reason, your doctor may check your iron levels regularly during Jesduvroq treatment. If you’re found to have low iron, your doctor may recommend an iron supplement.
If you have other questions about taking Jesduvroq with an iron supplement, talk with your doctor or pharmacist.
This drug comes with several precautions.
FDA warning: Increased risk of death and serious cardiovascular problems
This drug has a boxed warning. This is the most serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous.
Taking Jesduvroq increases the risk of serious cardiovascular problems, which may be fatal. These problems include:
- heart attack
- blood clots in the lungs or blood vessels, particularly around the dialysis access site (a surgically placed opening in your blood vessels that connects to the dialysis machine)
In clinical trials of Jesduvroq, blood clots affecting the dialysis access site were more common than other cardiovascular problems. Heart attack, stroke, and other blood clots were rare.
Some symptoms of serious cardiovascular problems are listed below:
- Heart attack. Symptoms can include nausea, sweating, shortness of breath, and pain in your neck, shoulder, chest, or arm.
- Stroke. Symptoms can include confusion, slurred speech, and weakness or numbness on one side of the face or body.
- Blood clots. Symptoms include pain or swelling or pain in the affected area and skin that’s warm or discolored.
Your risk may be increased if you’ve had a heart attack, stroke, or acute coronary syndrome in the past 3 months. Due to this risk, doctors typically will not prescribe Jesduvroq for people with these factors.
Your risk may also be higher if your hemoglobin level becomes greater than the recommended range. For this reason, your doctor will prescribe the lowest dosage of Jesduvroq needed to treat your condition.
If you have symptoms of a blood clot while taking Jesduvroq, tell your doctor right away. But if your symptoms seem life threatening or related to a heart attack or stroke, call 911 or a local emergency number right away.
For more information about this warning, talk with your doctor.
Before taking Jesduvroq, discuss your health history with your doctor. Jesduvroq may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:
- high blood pressure that isn’t well managed
- problems with your esophagus, stomach, or intestines, including peptic ulcer disease
- liver disease
- smoke tobacco
- previous allergic reaction to this or a similar drug
Note: For more information about the potential negative effects of Jesduvroq, see the “Jesduvroq side effects” section above.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.