Syfovre (pegcetacoplan) is a brand-name drug prescribed for an advanced form of macular degeneration in adults. Syfovre comes as an eye injection and can only be administered by a medical professional.

The Food and Drug Administration (FDA) approved Syfovre (pegcetacoplan injection) for the treatment of geographic atrophy related to dry age-related macular degeneration (AMD) in adults.

Syfovre belongs to a class of drugs called complement inhibitors and isn’t available in a generic version.

Keep reading for specific information about the dosage of Syfovre, including its strength and how the medication is given.

Syfovre is a clear liquid solution that a qualified medical professional injects into the eye.

The drug is available in a single strength, but a doctor will decide the exact amount that fits your needs.

If prescribed, the typical dose for Syfovre is 15 mg (0.1 mL of a 150 mg/mL solution). This amount is used for a single injection. Any leftovers from the preparation are not kept or reused.

Injections are given by a medical professional in each affected eye once every 25 to 60 days.

Long-term treatment with Syfovre

Syfovre is designed for long-term use. If a doctor and patient decide it’s safe and effective, injections will likely continue over time. Before treatment begins, a doctor will review the full plan.

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Syfovre is given as an intravitreal injection. This means an eye doctor injects it into the vitreous fluid, the thick, jelly-like substance at the back of the eye.

Before the treatment starts, your care team will check the pressure inside your eye. This is done with a tool that measures how firm the eye is. If the pressure is higher than expected, medication that helps lower eye pressure may be used.

Once the Syfovre dose is prepared, the injection is given immediately. Before the injection, the doctor uses numbing eye drops or gel and cleans the eye and eyelid with a special solution to remove any bacteria. They may also place an eyelid speculum, a small device that gently keeps the eye open during the procedure.

During the injection, the solution is slowly pushed into the eye. The care team ensures that the full 0.1 mL dose has been delivered by verifying that the syringe’s stopper reaches the end of the barrel. Each vial is intended for use with only one eye. If both eyes require treatment, a new vial is prepared, and a fully fresh sterile setup is used.

You may feel some pressure when the doctor injects Syfovre. Immediately after the injection, eye pressure is rechecked. The care team may also look at blood flow to the optic nerve to make sure everything appears as it should.

At the end of the procedure, you may be reminded to stay aware of any new symptoms, such as eye pain, redness, sensitivity to light, or blurry vision. These can be signs that you need immediate medical attention.

Depending on the dosing schedule, Syfovre injections will repeat every 25 to 60 days.

If you have questions about what to expect with Syfovre injections, a retina doctor or pharmacist can help. There are also more details on the Syfovre prescribing information label.

If you miss an appointment for Syfovre injections, it’s important to call the doctor’s office as soon as possible. They’ll reschedule your appointment and adjust the dosing schedule as needed.

Below are some frequently asked questions about Syfovre and dosage.

Syfovre starts to work after the first dose. But you likely won’t feel any different because the drug is designed to slow vision loss that occurs with geographic atrophy, not cure the condition. A doctor can determine how well the drug is working by performing regular eye exams.

No, the makers of Syfovre do not recommend getting the injections more than once every 25 to 60 days. Clinical trials have determined that this is how often you need the drug. If you have questions or concerns about your Syfovre dosage, a retina doctor can help. They’ll decide how often you should receive Syfovre injections.

The dosage described here is based on the manufacturer’s typical recommendations for the drug. If you and your care team decide Syfovre is a good fit, the prescribed amount may vary slightly based on individual needs.

If you’re curious about what dosage might work best for you, take some time to reflect on your treatment goals and preferences, and bring those questions to your trusted healthcare professional.

Along with dosage details, you may also like to explore other information about Syfovre to feel more informed about your options. These additional articles may be helpful:

  • Overview of Syfovre injections: Learn about other aspects of Syfovre.
  • Cost of Syfovre: Learn more about Syfovre and cost.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.