Key takeaways

  • Syfovre is a brand-name injectable medication specifically approved for adults to treat geographic atrophy, an advanced form of dry age-related macular degeneration (AMD).
  • The drug works by slowing the progression of vision loss associated with geographic atrophy, a condition where damage to the eye leads to vision impairment.
  • Syfovre may cause some side effects, most of which are mild. If you have any concerns about Syfovre, reach out to a healthcare professional.

Syfovre is a brand-name medication that comes in the form of an injectable solution. It’s prescribed for an eye condition called geographic atrophy due to age-related macular degeneration (AMD). Syfovre contains the active ingredient pegcetacoplan.

Syofovre works by blocking the pathways that lead to cell damage, and it can significantly slow the progression of geographic atrophy.

Syfovre details

You’ll find key information about Syfovre here.

  • Use: To treat geographic atrophy in adults.
  • Drug form: A solution given as an injection into the eye.
  • Generic available? No.
  • Prescription required? Yes.

The Food and Drug Administration (FDA) approves prescription drugs such as Syfovre to treat certain conditions, also referred to as indications.

Syfovre is FDA approved to treat geographic atrophy due to a certain type of age-related macular degeneration (AMD) in adults. It’s not approved for use in children.

While it can’t cure the condition completely, Syfovre works to help slow vision loss that occurs with geographic atrophy.

Syfovre comes as a solution in a single-use vial for injection into the eye. It’s available in one strength: 15 milligrams (mg) per 0.1 milliliters (mL) of solution. The vial contains 150 mg in 1 mL of solution.

The usual dosage is one 15 mg/0.1 mL injection into the affected eye. Each injection is given once every 25 to 60 days. Your eye specialist will tell you exactly how often you’ll receive injections of Syfovre.

Syfovre is given as an injection into a specific area of your eye. An eye specialist will give you the injection at their clinic or office. You won’t give yourself injections of the drug.

Syfovre is meant to be a long-term treatment. If you and your doctor determine that Syfovre is safe and effective for you, you’ll likely receive it long term.

As with all medications, the cost of Syfovre can vary. The actual price you’ll pay depends on your insurance plan and your location.

If you need financial support to pay for Syfovre or help to understand your insurance coverage, help is available.

A program called Syfovre ApellisAssist is available for Syfovre. For more information and to find out whether you’re eligible for support, call 888-273-5547 or visit the program website.

Generic version

Syfovre is not available in a generic form. A generic drug is an exact copy of the active ingredient in a brand-name medication. Generics tend to cost less than brand-name drugs.

Like any medication, Syfovre can cause side effects that can range from mild to serious. For a more in-depth explanation of Syfovre’s side effects, consider reading this article.

Some of the most common side effects include:

Serious side effects

Serious side effects from Syfovre aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

ALLERGIC REACTION

For some people, Syfovre can cause an allergic reaction. For mild allergic reaction symptoms, such as a mild rash, call your doctor as soon as possible. For severe allergic reaction symptoms, such as swelling or trouble breathing, call 911 or your local emergency number right away.

Reporting side effects

After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medications safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect during Syfovre treatment and want to tell the FDA about it, visit MedWatch or call 800-332-1088.

Syfovre is not known to interact with other medications, herbs, supplements, foods, or alcohol. The manufacturer did not list any interactions in the drug’s prescribing information.

However, this doesn’t mean that interactions won’t be recognized in the future. For example, new drugs could be approved that interact with Syfovre.

Before starting Syfovre treatment, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you take. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

This drug comes with several precautions.

Before receiving Syfovre, talk with your doctor about your health history. Syfovre may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of these factors are relevant to you:

  • eye infection
  • eye inflammation
  • increased pressure in your eye
  • previous allergic reaction to this or a similar drug
  • pregnancy
  • breastfeeding

Disclaimer: While Medical News Today strives for factual, comprehensive, and current drug information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses. Learn more about our approach to content integrity.