Syfovre is a brand-name injectable solution. It’s prescribed for geographic atrophy related to age-related macular degeneration. Syfovre contains the active drug pegcetacoplan.
Syfovre is FDA-approved to treat geographic atrophy related to age-related macular degeneration (AMD) in adults. Syfovre is the first drug to be approved for the treatment of geographic atrophy.
You’ll find key information about Syfovore below.
- Drug form: solution given as an injection
- Generic available? No
- Prescription required? Yes
- Controlled substance? No
- Year of FDA approval: 2021
Syfovre is available only as a brand-name medication. It’s not currently available in generic form.
A generic drug is an exact copy of the active drug in a brand-name medication. Generics usually cost less than brand-name drugs.
The Food and Drug Administration (FDA) approves prescription drugs such as Syfovre to treat certain conditions.
Syfovre for geographic atrophy related to age-related macular degeneration
Syfovre is FDA-approved to treat geographic atrophy related to age-related macular degeneration (AMD) in adults.
Geographic atrophy explained
AMD is an eye condition that occurs when aging causes damage to your macula. The macula is the center of your retina, which is the thin layer of tissue lining the back of your eye. With AMD, you have central vision loss that usually worsens over time.
Geographic atrophy is the most advanced stage of AMD. This condition may lead to permanent loss of central vision in one or both of your eyes.
Syfovre is used to help slow vision loss that occurs with geographic atrophy. You can learn more about this condition by visiting our eye health hub.
Syfovre and children
Syfovre is not FDA-approved for use in children. It’s not known for sure whether the drug is safe or effective for children.
As with all medications, the cost of Syfovre can vary. The actual price you’ll pay depends on your insurance plan and your location.
Financial and insurance assistance
If you need financial support to pay for Syfovre or help to understand your insurance coverage, help is available.
To learn more about saving money on prescriptions, check out this article.
Syfovre is not available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.
Syfovre can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while receiving Syfovre. These lists do not include all possible side effects.
For more information about the possible side effects of Syfovre, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.
Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you’d like to notify the FDA about a side effect you’ve had with Syfovre, you can do so through MedWatch.
Mild side effects
Below is a partial list of mild side effects of Syfovre. To learn about other mild side effects, talk with your doctor or pharmacist, or view Syfovre’s prescribing information.
Mild side effects of Syfovre can include:
- eye irritation or pain
- eye floaters (specks or dots in your vision)
- eye bleeding, which may appear as a red spot on the surface of your eye
- feeling as though something is in your eye
- cloudiness in the lens of your eye
- inflammation of your cornea (the top layer of your eye)
- mild allergic reaction*
Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.
* For more information about allergic reaction and Syfovre, see “Allergic reaction” below.
Serious side effects
Serious side effects from Syfovre aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Serious side effects and their symptoms can include:
- An increased risk of wet age-related macular degeneration. Symptoms can include:
- dark spots in your center vision
- trouble seeing colors or fine details
- seeing straight lines as wavy
- Detached retina (separation of the back of the eye and retina). Symptoms can include:
- increased number of eye floaters (specks or dots in your vision)
- darkness that spreads across your vision
- brief, sudden flashes of light in your outer vision
- Endophthalmitis (a type of serious eye infection). Symptoms can include:
- eye redness or pain
- white or yellow eye discharge
- blurred vision
- light sensitivity
- Inflammation of various areas inside the eye. Symptoms can include:
- eye redness or pain
- eye floaters
- eye sensitivity to light
- blurred vision
- Temporary increase in eye pressure after receiving a Syfovre injection. Symptoms can include:
- eye redness, pain, or irritation
- blurred vision
- Severe allergic reaction.*
* For details about allergic reaction and Syfovre, see “Allergic reaction” below.
Symptoms of a mild allergic reaction can include:
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have an allergic reaction to Syfovre, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
The following information describes dosages of Syfovre that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
Drug forms and strengths
Syfovre comes as a solution in a single-use vial. It’s available in one strength of 15 milligrams (mg) in 0.1 milliliters (mL) of solution.
Dosage for geographic atrophy related to age-related macular degeneration
Syfovre is used for geographic atrophy related to age-related macular degeneration (AMD).
The usual dosage for this purpose is one injection (15 mg/0.01 mL) in the affected eye. Each injection is given once every 25–60 days. Your eye specialist will tell you exactly how often you’ll receive injections of Syfovre.
How Syfovre is administered
Syfovre is given as an injection into your eye. An eye specialist will give you the injection at their clinic or office. You won’t give yourself injections of the drug.
About receiving Syfovre
Below you’ll find information about receiving Syfovre.
- If you miss a dose: If you miss an appointment to receive your Syfovre injection, call your eye specialist as soon as possible to reschedule.
- Length of use: Syfovre is meant to be a long-term treatment. If you and your doctor determine that Syfovre is safe and effective for you, you’ll likely receive it long term.
However, this doesn’t mean that interactions won’t be recognized in the future. For example, new drugs could be approved that interact with Syfovre.
Before starting Syfovre treatment, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you take. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
If you can become pregnant, consider the following information about pregnancy, birth control, and breastfeeding.
Syfovre and pregnancy
It’s not known whether Syfovre should be used during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before using this medication.
Syfovre and birth control
It’s not known whether Syfovre is safe to use during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re receiving Syfovre.
Note: Sex and gender exist on spectrums. Use of the term “female” and “male” in this article refers to sex assigned at birth.
For females using Syfovre
Females who can become pregnant should use birth control during treatment and for at least 40 days after the last injection.
For males using Syfovre
The manufacturer of Syfovre hasn’t given birth control recommendations for males receiving the drug.
If you’re a male using Syfovre and have a sexual partner who can become pregnant, talk with your doctor. They’ll advise you on your birth control needs while receiving this drug.
Syfovre and breastfeeding
It’s not known whether Syfovre should be used while breastfeeding. If you’re breastfeeding or planning to do so, talk with your doctor before receiving this medication.
Here are answers to some frequently asked questions about Syfovre.
Does Syfovre cause long-term side effects?
Yes, Syfovre may cause certain side effects that can lead to long-term vision loss. These side effects may start during treatment and continue for a long time, even after stopping Syfovre treatment.
Specifically, Syfovre may cause:
- an increased risk of wet age-related macular degeneration
- detached retina (separation of the back of the eye and retina)
- endophthalmitis (a type of serious eye infection)
If you have questions about long-term side effects of Syfovre, talk with your doctor.
Is Syfovre the only treatment option for geographic atrophy, or are there alternatives?
Syfovre is the first and only drug approved for treating geographic atrophy. No other medications are currently approved for this use.
Your doctor can recommend whether alternative treatments for geographic atrophy may be right for you. For example, certain foods and supplements are thought to help slow vision loss that occurs with this condition. These include:
- foods high in folate, such as black-eyed peas, asparagus, and Brussels sprouts
- a combination of zinc, vitamin C, vitamin E, or beta-carotene supplements
To learn more about treatment options for geographic atrophy, talk with your doctor.
Can Syfovre be used for other eye-related conditions?
With off-label drug use, a drug approved by the Food and Drug Administration (FDA) is prescribed for a purpose other than what it’s approved for.
Your doctor can recommend whether Syfovre may be prescribed off-label for other eye-related conditions.
This drug comes with several precautions.
Before receiving Syfovre, talk with your doctor about your health history. Syfovre may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of these factors are relevant to you:
- eye infection
- eye inflammation
- increased pressure in your eye
- previous allergic reaction to this or a similar drug
Note: For more information about the potential adverse effects of Syfovre, see the “Syfovre side effects” section above.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.