Takhzyro (lanadelumab-flyo) is a brand-name drug prescribed to prevent attacks of hereditary angioedema (HAE) in adults and some children. It comes as a liquid solution that’s given as a subcutaneous injection, typically every 2 weeks.

Takhzyro is approved by the Food and Drug Administration (FDA) to prevent attacks of hereditary angioedema (HAE) in adults and children ages 2 years and older.

Takhzyro is a biologic and belongs to a drug class called kallikrein inhibitors. Takhzyro is not available in a biosimilar version.

Keep reading for specific information about the dosage of Takhzyro, including its strengths and how to use the medication. For a comprehensive look at Takhzyro, see this article.

Note:This article describes typical dosages for Takhzyro provided by the drug’s manufacturer. When using Takhzyro, always follow the dosage prescribed by your doctor.

The typically recommended dosages for Takhzyro are described below.

Takhzyro form

Takhzyro comes as a solution that’s given as a subcutaneous injection (an injection just beneath your skin). A doctor or another healthcare professional will give your injections. Or they can teach you or your caregiver how to inject the medication.

Takhzyro is available as a single-dose prefilled syringe or a single-dose vial.

Takhzyro strengths

Takhzyro comes in one strength of 300 milligrams (mg) per 2 milliliters (mL).

Typical dosages

The following information describes dosages that are commonly used or recommended in adults. However, be sure to use the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for HAE

The recommended dosage of Takhzyro to help prevent attacks of HAE is 300 mg given as a subcutaneous injection every 2 weeks.

If you haven’t had an attack for more than 6 months, your doctor may decrease your dosage to 300 mg every 4 weeks.

Never change your dosage on your own. Your doctor will make dosage adjustments as needed.

For more information about your specific dosage, talk with your doctor.

Children’s dosage

Takhzyro is approved to prevent attacks of HAE in children ages 2 years and older. Your child’s dosage will be based on their age.

  • For children ages 2 years to less than 6 years: 150 mg given as a subcutaneous injection every 4 weeks.
  • For children ages 6 years to less than 12 years: 150 mg given as a subcutaneous injection every 2 weeks. If your child hasn’t had an attack for more than 6 months, their doctor may decrease the dosage to 150 mg every 4 weeks.
  • For children ages 12 years and older: 300 mg given as a subcutaneous injection every 2 weeks. If your child hasn’t had an attack for more than 6 months, their doctor may decrease the dosage to 300 mg every 4 weeks.

Talk with your child’s doctor if you have questions about their dosage. Never change the dosage without first talking with your child’s doctor.

Long-term treatment

Takhzyro is meant to be used as a long-term treatment. If you and your doctor determine that Takhzyro is safe and effective for you, you’ll likely use it long term.

Before you start Takhzyro treatment, your doctor will discuss your treatment plan with you.

The Takhzyro dosage your doctor prescribes will depend on several factors, including:

  • your age
  • how your body responds to Takhzyro
  • the severity of your HAE

Takhzyro comes as a liquid solution in a single-dose prefilled syringe or a single-dose vial. It’s given as a subcutaneous injection.

Your doctor may give you the first dose, but they’ll likely show you or your caregiver how to inject the medication. Make sure to use Takhzyro according to the instructions your doctor provides.

Here are some tips on how to use Takhzyro:

  • Refrigeration: The prefilled syringes and vials should be stored in the refrigerator. You should remove the medication from the refrigerator 15 minutes before your injection. This allows the solution to warm up to room temperature before you inject it.
  • Injection location: If you’re self-injecting Takhzyro, you can inject the medication into your abdomen or thigh. If you inject into your abdomen, avoid any area within 2 inches of your belly button. If someone else is giving you the dose, they may inject it into your abdomen, thigh, or upper arm.
  • Detailed instructions: You can find an instructional video and step-by-step instructions on the manufacturer’s website.

If you have questions about how to use Takhzyro, talk with your doctor or pharmacist.

If you miss an injection of Takhzyro, call your doctor or pharmacist. They may suggest that you inject your Takhzyro dose immediately or wait until your next scheduled time.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

It’s important that you don’t use more Takhzyro than your doctor prescribes. For some medications, using more than the recommended amount may lead to harmful effects or overdose.

If you use more than the recommended amount of Takhzyro

Call your doctor right away if you believe you’ve used too much Takhzyro. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Below are some frequently asked questions about Takhzyro.

Is the dosage of Takhzyro similar to the dosage of Cinryze?

No, the forms and how often you take each drug are different.

Takhzyro comes as a liquid solution in prefilled syringes or a vial. It’s given as a subcutaneous injection once every 2 weeks or once every 4 weeks. A subcutaneous injection is an injection just under your skin. You, your caregiver, or a healthcare professional can give your injections.

Cinryze (C1 esterase inhibitor [human]) comes as a powder that must be mixed with liquid to form a solution. It’s given as an IV infusion every 3 or 4 days. An IV infusion is an injection that’s given into a vein over a period of time. An infusion is given by a healthcare professional.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Takhzyro to start working?

Takhzyro starts working after your first dose. However, it typically takes around 5 days for the drug to reach a high enough concentration in your body to start preventing HAE attacks. It may take up to 70 days for the drug to reach its full effect in preventing attacks.

Talk with your doctor if you have questions about what to expect with Takhzyro treatment.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Takhzyro for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Takhzyro without your doctor’s recommendation. If you have questions about the dosage of Takhzyro that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Takhzyro. These additional articles might be helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.