People with leukemia can develop skin-related issues, such as a rash or bruising. Various types of rash can occur, such as petechiae and purpura, which appear when small blood vessels break under the skin. Some rashes involve bumps, papules, or nodules on the skin’s surface.
These changes can lead to various skin symptoms. Treatment for leukemia can also affect the skin.
Skin symptoms that can occur with leukemia include:
This article looks at some skin changes that can occur with leukemia, how to identify them, and which treatment, if any, may help.
The following images show some ways in which leukemia can affect the skin. More detail is below.
Here are some of the skin rashes and symptoms a person may experience with leukemia.
Petechiae and purpura
Petechiae and purpura can be
Leukemia disrupts the production of platelets, which usually enable blood to clot. As platelet levels fall, it becomes harder for them to block any burst capillaries. As a result, the blood can leak out into the skin.
Petechiae and purpura may appear red, purple, or brown. On darker skin, they can be harder to spot, but they may be easier to see on lighter areas, for example, the soles of the feet or palms of the hands.
To distinguish petechiae from a skin rash, a person can press down on the affected area using a finger or thumb. Petechiae and purpura will not change color, but a rash will turn white.
Petechiae and purpura
Easy bruising and bleeding are common symptoms of leukemia. A person may notice them before they receive a diagnosis.
Bruises are common after an injury, but they may be a sign of leukemia if:
- they happen even after a small knock, or a person cannot remember doing anything to cause them
- they appear in unusual places, such as the back or hands
- there are many bruises, or they happen often
- they take longer than usual to disappear
- they occur along with easy bleeding
As with petechiae, the body cannot prevent blood vessels from bleeding under the skin when an injury occurs. However, these bruises are different from petechiae. They look like regular bruises.
The skin develops small bumps that look like a rash.
A person may notice:
- papules on the skin
- nodules that feel firm or rubbery
In some cases, the following may occur:
- erythema, which makes the skin look red or darker in color, depending on the person’s skin tone
- erythroderma — a widespread skin inflammation that can be life threatening
- skin ulcers
The lesions may be red, brown, yellow, blue, gray, or purple. On darker skin, they can be harder to see. As with petechiae and purpura, they may be more visible on lighter areas, such as the hands and feet.
With deeper lesions, the skin color may not change.
If chemotherapy and other treatments for leukemia are effective, the symptoms of leukemia cutis will disappear.
People with leukemia often bleed more easily than before. This is because the blood does not clot effectively due to low platelet levels.
The individual may notice:
- bleeding a lot after small wounds
- bleeding gums when brushing the teeth
- blood in urine
- blood in stool
It can lead to:
- inflamed plaques or nodules on the skin of varying sizes and in a pattern that is not symmetrical
- pustular lesions, ulcers, and blisters
- mouth ulcers, in some cases
- joint pain
- eye inflammation
Skin changes can affect the face, neck, chest, and back. They are more likely in the upper extremities, such as the hands, but can also occur in the lower extremities.
Steroid treatment may
Mastocytosis is a rash that
The mast cells trigger the release of compounds that stimulate the blood vessels.
The symptoms can resemble those of an allergic reaction. They can affect all the body’s systems.
Skin symptoms include:
- a rash
- swelling under the skin, known as angioedema
Anaphylaxis is a severe allergic reaction that can be life threatening. The symptoms develop suddenly and include:
- swelling of the face or mouth
- fast, shallow breathing
- a fast heart rate
- clammy skin
- anxiety or confusion
- blue or white lips
- fainting or loss of consciousness
If someone has these symptoms:
- Check whether they are carrying an epinephrine pen. If they are, follow the instructions on the side of the pen to use it.
- Dial 911 or the number of the nearest emergency department.
- Lay the person down from a standing position. If they have vomited, turn them onto their side.
- Stay with them until the emergency services arrive.
Some people may need more than one epinephrine injection. If the symptoms do not improve in 5–15 minutes, or they come back, use a second pen if the person has one.
Leukemia often causes mouth problems. Sores, oral infections, and other symptoms may be early signs of leukemia.
Oral symptoms of leukemia
- swelling of the gums or in the cheeks
- bleeding from the gums
- mouth ulcers
- petechiae in the mouth
- paleness in the mucous membranes, such as inside the cheeks
- reduced ability to move the jaw, known as trismus or lockjaw
Topical treatments and over-the-counter pain medications can
People with leukemia can also develop anemia.
This can cause the skin to appear pale or greyish if a person has darker skin.
Red blood cells contain a protein called hemoglobin, which carries oxygen from the lungs to the rest of the body. A reduction in hemoglobin lowers the amount of oxygen circulating in the body.
As well as paleness, this
- fatigue and weakness
- body aches
- difficulty breathing
- faintness or dizziness
- a rapid heartbeat
Anemia can happen for many reasons, including leukemia and treatments for leukemia, such as chemotherapy or radiation therapy.
A blood transfusion can
In addition to a rash, leukemia can cause a range of symptoms, including:
Rashes and other skin problems can occur for many reasons.
However, a person should see a doctor if they:
- are bleeding or bruising more easily than before
- have purple patches on the skin that could be petechiae
- start developing frequent mouth sores and other oral problems
- have other symptoms, such as fatigue, that could indicate a problem
These may be early signs of leukemia.
A person should also contact their treatment team if they have a diagnosis of leukemia and are concerned about new skin symptoms.
Here are some questions people often ask about leukemia skin symptoms.
What does a leukemia rash look like?
This will depend on the rash, but leukemia and other health conditions can cause tiny red spots called petechiae on the skin or purple areas called purpura. The patches will not disappear if a person presses on them.
What does leukemia bruising look like?
A person with leukemia may bruise more easily than before and in unusual places. They may also develop petechiae or purpura — red or purple patches that, like bruises, result from bleeding under the skin.
Is a rash a symptom of leukemia?
Petechiae and purpura can be the first sign of leukemia a person notices. However, they can also result from other conditions. People with leukemia can also be more prone to infections, including skin infections.
A wide range of factors can lead to a rash, easy bruising, and other skin symptoms. However, people with leukemia may be more susceptible to certain skin changes.
If a person notices new or unusual skin symptoms, they should seek medical advice. A doctor can often prescribe effective treatment for skin rashes, but they may also wish to see if there is an underlying cause.