Vyvgart (efgartigimod alfa-fcab) is a brand-name drug that’s prescribed for myasthenia gravis in adults. Vyvgart comes as an intravenous (IV) infusion that’s given by a healthcare professional. The dosage can vary depending on certain factors.
The Food and Drug Administration (FDA) has approved Vyvgart to treat generalized myasthenia gravis (gMG) in adults who are anti-acetylcholine receptor (AChR) antibody positive. GMG affects the muscles throughout your body.
Keep reading for specific information about the dosage of Vyvgart, including its strength and how you’ll receive the medication. For a comprehensive look at Vyvgart, see this article.
Note: This article describes typical dosages for Vyvgart provided by the drug’s manufacturer. However, your doctor will prescribe the Vyvgart dosage that’s right for you.
The information below describes Vyvgart’s typical dosages and other details about the drug.
Vyvgart comes as a vial solution that you receive as an IV infusion. A healthcare professional always administers it.
Vyvgart comes in one strength: 20 milligrams per milliliter of solution (20 mg/mL). Each 20-mL, single-use vial contains 400 mg of active drug.
The following information describes dosages that doctors commonly prescribe or recommend in adults. Your doctor will determine the best dosage to fit your needs.
Dosage for myasthenia gravis
Doctors may prescribe Vyvgart to treat generalized myasthenia gravis (gMG).
If your doctor prescribes Vyvgart for your gMG, they will likely base your dosage on your body weight in kilograms (kg). 1 kg is equal to 2.2 pounds (lb).
Typically, you’ll receive 10 mg per kg of body weight. You’ll receive this dose as an IV infusion once per week for 4 weeks. This is called a treatment cycle. After your fourth dose, you’ll have a break before your next treatment cycle. Your doctor will determine when your next treatment cycle begins.
If you weigh 120 kg (264 lb) or more, your Vyvgart dosage will likely be 1,200 mg per infusion.
For more information about your specific dosage, talk with your doctor.
Vyvgart is meant to be used as a long-term treatment. If you and your doctor determine that Vyvgart is safe and effective for you, you’ll likely use it long term.
Before you start taking Vyvgart, your doctor will discuss your treatment plan with you.
Your doctor or another healthcare professional will give you the IV infusion of Vyvgart. First, they’ll dilute Vyvgart with another liquid to make a solution for infusion. You’ll likely receive this infusion at your doctor’s office, infusion center, or a hospital. The infusion takes about 1 hour.
On the day of your infusion, your doctor may recommend that you:
- drink plenty of water
- eat as you usually would
- wear comfortable, layered clothing in case it’s cold in the office
- bring a list of medications that you take to your appointment
A healthcare professional will check your pulse, blood pressure, and temperature during your infusion. They’ll monitor you during and after the infusion.
If you have questions about what to expect with Vyvgart, talk with your doctor or pharmacist. There are also step-by-step instructions on the manufacturer’s website.
If you miss your appointment for a Vyvgart infusion, call your doctor’s office as soon as possible to reschedule. You should be able to receive your Vyvgart infusion if it’s within 3 days of your scheduled dose. Then, you’ll resume your regular schedule for the next dose.
If it’s been more than 3 days since your missed appointment, let your doctor know. They’ll recommend when you should get your next infusion.
If you need help remembering your appointments, try setting an alarm or downloading a reminder app on your phone.
Below are some commonly asked questions about Vyvgart.
How long does it take for Vyvgart to start working?
Vyvgart starts to work after your first dose. However, you may not feel the drug working right away. Your doctor will monitor your condition during treatment to see whether the drug is effective for your condition. They’ll also ask you to keep track of your symptoms to see if Vyvgart is working for you.
Talk with your doctor if you have questions about what to expect with Vyvgart treatment.
How does the dosage of Vyvgart compare with Vyvgart Hytrulo?
As with Vyvgart, doctors prescribe Vyvgart Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) to treat generalized myasthenia gravis (gMG).
The typical dose of Vyvgart is 10mg/kg of body weight. A healthcare professional gives this as an IV infusion over 1 hour.
The typical dose of Vyvgart Hytrulo is 1,008 mg efgartigimod alfa and 11,200 units hyaluronidase. A healthcare professional gives this dose subcutaneously over 30–90 seconds.
You receive both medications once per week for 4 weeks. This is known as a treatment cycle. After the fourth week, you’ll take a break. Your doctor will let you know when you will begin another treatment cycle.
If you have questions about how Vyvgart and Vyvgart Hytrulo compare, talk with your doctor.
The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Vyvgart for you, they will prescribe the dosage that’s right for you.
If you have questions about the dosage of Vyvgart that’s best for you, talk with your doctor.
Besides learning about dosage, you may want other information about Vyvgart. These additional articles might be helpful:
- More about Vyvgart. For information about other aspects of Vyvgart, refer to this article.
- Cost. If you’d like to learn about Vyvgart and cost, see this article.
- Details about generalized myasthenia gravis (gMG). For details about gMG, see our list of gMG articles.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.