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Syphilis is a sexually transmitted infection (STI) that, without treatment, can have serious health implications. Nowadays, many brands offer at-home test kits for STIs.

This article discusses four syphilis home test options, how the tests work, some information on reliability, and when to contact a doctor.

A person can order a home syphilis test online or buy one in-store from certain pharmacies.

Usually, for a syphilis test, a person will need to use a finger prick to get a small blood sample. More thorough tests that can identify various STIs may also require a urine or swab sample.

A person should speak with a pharmacist or another healthcare professional to understand which tests are reliable and accurate.

Traditional tests wherein a healthcare professional collects the sample will always be more accurate. A person conducting a home test may not have needed to collect a sample before, so they may be more likely to do this incorrectly.

One 2015 systematic review compared the accuracy of self-collected versus clinician-collected samples for STIs. It found that samples collected by clinicians were more reliable, though it said that these samples could still yield inaccurate results.

It is worth noting that there are currently no home tests for syphilis that have Food and Drug Administration (FDA) approval.

Below is a list of some home syphilis test options that a person can purchase online.

Please note that the writer of this article has not tried any of these products. All information presented here is purely research-based.


This test checks for multiple STIs from one sample. A person can purchase a Standard 5 test — which tests for syphilis, chlamydia, gonorrhea, HIV, and trichomoniasis — for $149.

A person can also purchase a Complete 10 test — which tests for all the above plus Gardnerella, Mycoplasma pneumoniae, ureaplasma, and herpes simplex virus 1 and 2 — for $349.

LetsGetChecked accepts HSA and FSA payments, and a person can subscribe to receive the test every 3 months, which reduces the cost by 30%.

The tests come in discreet packaging and include a prepaid shipping label. A person needs to provide a finger prick blood and urine sample and return them to the laboratory on the same day.

The company claims that results are available online within 2–5 days. If needed, nurses are available to contact 24/7 to discuss results and treatment.

LetsGetChecked claims that the laboratories it uses to analyze the results are the same used by healthcare professionals, so they are highly reliable. The company says that these laboratories are CLIA and College of American Pathologists certified.

It also states that the test kits themselves are manufactured in an ISO 13485 accredited facility.

Read more about LetsGetChecked here.


This test uses a finger prick sample that a person will send back to a laboratory for testing.

The price is $49, but members of Everlywell can purchase the test for $24.99. The company accepts payments from flexible spending accounts (FSA) and health savings accounts (HSA). There is no charge for the shipping, and the packaging is discreet.

Within the test pack is all the equipment needed for the test, alongside a prepaid return shipping label for sending the sample to the laboratory.

Everlywell states that the laboratories it works with are Clinical Laboratory Improvement Amendments (CLIA) certified. This means the company meets high standards and obtains state and federal certifications.

It also claims that a local certified physician approves the tests and that personal data are kept confidential.

The company claims that the test has 99% accuracy, and if a positive result is generated, one of its physicians will contact the person directly to discuss the next steps.

Read more about Everlywell here.

STD Rapid Test Kits

This brand offers a variety of different test kits in either singles or combos. For example, a person can purchase a syphilis test for $29, which the company claims has a 98% accuracy rate. Alternatively, a customer can purchase three — which test for chlamydia, gonorrhea, and syphilis — for $69.

The results are processed within 15 minutes, as there is no laboratory involvement. It uses a finger prick test, and a testing cassette is included in the packaging.

One line should appear in the control section to indicate that the sample is being read. If the test is positive, a second line will appear. If no lines appear, the test is invalid, and a person must take it again.

The website does not say anything about device or factory accreditation.

iCare Syphilis Test Kit

This is a rapid antigen test that generates results within 15 minutes. iCare claims that the test is 99% accurate, and it costs $29.

The company claims that this testing kit is the same as those that government clinics and test laboratories use.

The iCare syphilis test uses a blood sample taken with a finger prick. The provided pipette then collects the blood sample, and a person should drip one or two drops onto the testing cassette with the provided dilution liquid.

One line on the control level indicates a negative result, and two lines indicate a positive result. A detailed instruction booklet comes with the test kit.

iCare says that the testing device is Current Good Manufacturing Practice and TUV ISO 13485 certified.

The Centers for Disease Control and Prevention (CDC) say that the following groups should undergo regular testing:

  • pregnant people
  • men who have sex with men
  • people with HIV
  • people with partners who have tested positive for syphilis

Planned Parenthood says that many people with STIs have no symptoms at all. It explains that anyone who has had vaginal, anal, or oral sex should consider getting tested, particularly if it was unprotected. Also, if a person’s sexual partner tests positive, they should take a test as well.

A person can choose to consult a doctor and have their test in a clinic rather than at home.

A person should consult a doctor if they receive a positive STI result from their home test.

A person should also contact a doctor if they have any symptoms that may indicate syphilis, regardless of the result of the home test. They may have another STI or health condition that needs medical attention.

Many people with syphilis do not have symptoms immediately. Some primary stage symptoms include painless sores on the genitals, mouth, anus, or rectum and enlarged lymph nodes around the sore.

Some secondary stage symptoms may include:

Learn more about secondary syphilis here.

Latent and tertiary stage syphilis can occur when a person does not receive treatment. These infections can cause major damage to the organs and nervous system.

Learn more about syphilis here.

Anyone with concerns about syphilis symptoms or complications should speak with a doctor.

There are various home syphilis testing kits available that their manufacturers claim to be accurate. All these tests use a finger prick to collect a blood sample.

A person should contact a doctor if they receive a positive result from their home test. A doctor can also offer testing.