Breztri Aerosphere (budesonide/glycopyrrolate/formoterol fumarate) is a brand-name drug that’s prescribed for chronic obstructive pulmonary disease (COPD) in adults. Breztri Aerosphere comes as an inhaler that’s typically used twice per day.

Breztri Aerosphere contains three medications:

Breztri Aerosphere is not available in a generic version.

Keep reading for specific information about the dosage of Breztri Aerosphere, including its strength and how to use the medication. For a comprehensive look at Breztri Aerosphere, see this article.

Note: This article describes typical dosages for Breztri Aerosphere provided by the drug’s manufacturer. When taking Breztri Aerosphere, always follow the dosage prescribed by your doctor.

Below is information about Breztri Aerosphere’s dosage for its approved use.

Breztri Aerosphere form

Breztri Aerosphere comes as a metered-dose inhaler.

Breztri Aerosphere strength

A dose of Breztri Aerosphere is two puffs. Each dose contains:

  • 320 micrograms (mcg) of budesonide
  • 18 mcg of glycopyrrolate
  • 9.6 mcg of formoterol fumarate

Typical dosages

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for chronic obstructive pulmonary disease (COPD)

The dosage of Breztri Aerosphere for COPD is two puffs twice per day. You’ll inhale two puffs in the morning and two puffs in the evening.

Long-term treatment

Breztri Aerosphere is meant to be used as a long-term treatment. If you and your doctor determine that Breztri Aerosphere is safe and effective for you, you’ll likely take it long term.

Breztri Aerosphere comes as an inhaler that you’ll use at home.

To use, place the mouthpiece in your mouth and close your lips around it. As you breathe in, spray one puff. Hold your breath for up to 10 seconds and then repeat for the second puff.

For more details about using your Breztri Aerosphere inhaler, watch these videos.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you miss a dose, use your Breztri Aerosphere inhaler as soon as you remember. Then, resume your normal schedule. Do not take two doses (four puffs) at once to make up for the missed dose.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

If you use more Breztri Aerosphere than your doctor prescribes, you may develop harmful effects.

It’s important that you do not use more Breztri Aerosphere than your doctor advises.

Symptoms of an overdose

Overdose symptoms of Breztri Aerosphere can include:

If you take more than the recommended amount of Breztri Aerosphere

Call your doctor right away if you believe you’ve taken too much Breztri Aerosphere. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Breztri Aerosphere for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Breztri Aerosphere without your doctor’s recommendation. If you have questions about the dosage of Breztri Aerosphere that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Breztri Aerosphere. These additional articles might be helpful:

  • More about Breztri Aerosphere. For information about other aspects of Breztri Aerosphere, refer to this article.
  • Side effects. To learn about side effects of Breztri Aerosphere, see this article. You can also look at the Breztri Aerosphere prescribing information.
  • Drug comparison. To find out how Breztri Aerosphere compares with Trelegy Ellipta, read this article.
  • Cost. If you’d like to learn about Breztri Aerosphere and cost, see this article.
  • Details about chronic obstructive pulmonary disease (COPD). For details about COPD, see our COPD hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.