Dexilant interactions: Alcohol, medications, and other factors

Dexilant interactions with other medications  

Before you start treatment with Dexilant, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Dexilant interacts with supplements, herbs, or vitamins, see the “Dexilant and other interactions” section.)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Here’s a table of drugs that can interact with Dexilant. Keep in mind that this list doesn’t include all drugs that may interact with Dexilant. Some of these interactions are described in detail in “Drug interactions in depth.”

When to avoid Dexilant

In some cases, factors or conditions could prevent your doctor from prescribing Dexilant due to the risk of harm. These are known as contraindications. The contraindications of Dexilant include:

Taking rilpivirine or a medication that contains it

Doctors typically will not prescribe Dexilant in combination with the medication rilpivirine (Edurant) or medications that contain it. Dexilant can make rilpivirine less effective. This can cause the medication to stop working to treat HIV.

Rilpivirine and medications that contain it are used to treat HIV.

Medications that contain rilpivirine include:

• rilpivirine/cabotegravir (Cabenuva)
• dolutegravir/rilpivirine (Juluca)
• emtricitabine/rilpivirine/tenofovir alafenamide fumarate (Odefsey)
• emtricitabine/rilpivirine/tenofovir disoproxil fumarate (Complera)

Instead of Dexilant, your doctor can recommend other treatments for your condition that don’t interact with rilpivirine. Do not make changes to your HIV treatment plan unless your doctor specifically tells you to do so.

Having had an allergic reaction to Dexilant or any of its ingredients

If you have had an allergic reaction to Dexilant or any of its ingredients, your doctor will likely not prescribe Dexilant. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better options for you.

Note: Before you start treatment with Dexilant, it’s important to tell your doctor if these contraindications apply to you. They can determine whether to prescribe Dexilant.

Dexilant interaction with alcohol

If you drink alcohol, your doctor will likely recommend that you do not drink it while taking Dexilant. They may also advise you not to take any prescription or over-the-counter drugs that contain alcohol during Dexilant treatment.

Alcohol may alter the effects of Dexilant and make it less effective. If you have questions about drinking alcohol while taking Dexilant, talk with your doctor.

Drug interactions in depth

Here’s a closer look at certain drug interactions of Dexilant.

Certain antibiotics

Dexilant can interact with certain antibiotics, which are used to treat infections caused by bacteria.

Interaction result: This interaction will differ based on the specific antibiotic. Certain antibiotics may not work as well if they are taken with Dexilant. Other antibiotics can make Dexilant less effective or increase your risk of side effects of Dexilant.

Interaction explained: The antibiotic rifampin can speed up the activity of certain enzymes in your body that help break down Dexilant. As a result, Dexilant may not work as well.

On the other hand, the antibiotic clarithromycin slows the activity of a certain enzyme. This can increase the level of Dexilant in your body. Taking clarithromycin and Dexilant together may increase your risk of side effects of Dexilant.

Certain antibiotics may not work as well if they’re taken with Dexilant. Certain antibiotics depend on stomach acid to be absorbed properly after you take a dose. But Dexilant works by decreasing stomach acid. As a result, certain antibiotics may not be absorbed or work as well if they’re taken with Dexilant.

Examples of antibiotic drugs: Here are some antibiotics that may interact with Dexilant:

• cefuroxime
• clarithromycin
• rifampin (Rimactane)

Steps you or your doctor may take: Steps your doctor may take will depend on the specific antibiotic. Doctors typically avoid prescribing Dexilant and rifampin together. They may prescribe a different antibiotic that doesn’t interact with Dexilant if one is available for your infection. In other cases, they may recommend temporarily stopping treatment with Dexilant until you finish taking the antibiotic.

Mycophenolate mofetil

Dexilant can interact with mycophenolate mofetil (CellCept), which is prescribed after a solid organ transplant to prevent organ rejection.

Interaction result: Taking Dexilant and mycophenolate mofetil together can make mycophenolate mofetil less effective.

Interaction explained: Mycophenolate mofetil relies on stomach acid to be absorbed properly after you take a dose. Dexilant works by decreasing stomach acid. As a result, mycophenolate mofetil may not work as well if it’s taken with Dexilant.

Steps you or your doctor may take: Due to this risk, your doctor may suggest avoiding Dexilant if you’re taking mycophenolate mofetil to prevent organ rejection. Instead, they can recommend other treatments for your condition that are safer to take with mycophenolate mofetil.

Dexilant and other interactions

Dexilant may have other interactions, such as with supplements, foods, vaccines, or lab tests. Keep in mind that the following information does not include all other possible interactions with Dexilant.

Dexilant interactions with supplements

Before you start treatment with Dexilant, tell your doctor and pharmacist which supplements, herbs, and vitamins you take. By sharing this information with them, you may help prevent possible interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Dexilant interactions with herbs

Doctors will typically recommend you avoid taking St. John’s wort with Dexilant. St. John’s wort is an herbal supplement that may be used to treat depression and other conditions.

St. John’s wort may speed up the activity of an enzyme in your body called CYP3A4. This enzyme helps break down Dexilant.

By speeding up this enzyme, St. John’s wort can cause Dexilant to break down more quickly. And this may lead to a low level of Dexilant in your system. If the level of Dexilant in your system is too low, the drug may not work to treat your condition.

Your doctor may be able to suggest a treatment option other than St. John’s wort.

Dexilant interactions with vitamins and minerals

Dexilant can interact with the mineral iron. Iron supplements are used to maintain healthy iron levels. Iron may also be found in some multivitamins.

Dexilant can cause your body to stop absorbing iron. This means the iron supplement may not work to maintain healthy iron levels in your body.

Before you start treatment with Dexilant, tell your doctor and pharmacist which vitamin or mineral supplements you take. They can advise you on whether Dexilant may interact with them.

Dexilant interactions with food

There were no reports of food interactions with Dexilant. If you’d like to learn more about eating certain foods during treatment with Dexilant, talk with your doctor.

Dexilant interactions with vaccines

There aren’t any known interactions between Dexilant and vaccines. Talk with your doctor or pharmacist to check whether you’re due for any vaccines.

Dexilant interactions with lab tests

Dexilant may interact with the following lab tests:

• Certain tests for neuroendocrine tumors or Zollinger-Ellison syndrome: These include the secretin stimulation test. Taking Dexilant may cause a false positive result, meaning the test suggests you have a neuroendocrine tumor (such as a gastrinoma, a possible cause of Zollinger-Ellison syndrome) when one isn’t present.
• Urine drug screening test: This checks for the presence of THC, a component of cannabis. Taking Dexilant may cause a false-positive result, meaning the urine drug screening test could show you have THC in your urine even if you do not.

Because of this, it’s important to tell the person giving you the test that you’re taking Dexilant.

For additional information, talk with your doctor or pharmacist.

DEXILANT INTERACTION WITH CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Dexilant. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Dexilant. The impact of cannabis may affect how well you stick to your Dexilant treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Dexilant and health-related interactions

Certain medical conditions and other factors may increase the risk of interactions with Dexilant. Be sure to talk with your doctor about your health history before starting treatment with Dexilant. It may not be the right treatment option if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Dexilant include:

• Liver problem: Be sure to let your doctor know if you have a liver problem, such as cirrhosis, before taking Dexilant. Doctors typically won’t prescribe Dexilant if you have a severe liver problem. For mild or moderate liver problems, they typically prescribe a lower Dexilant dosage. Your body relies on your liver to break down Dexilant after you take a dose. Liver problems can interfere with this and may cause an increased level of Dexilant in your system. This can raise your risk of side effects of Dexilant, such as diarrhea or gas.
• Low blood magnesium: Treatment with Dexilant may lower the level of magnesium in your blood. This can cause new or worsened cases of hypomagnesemia (low blood magnesium). If you have hypomagnesemia, talk with your doctor to determine whether Dexilant is safe for you.
• Low vitamin B12 level: Treatment with Dexilant may lower the level of vitamin B12 in your blood. This can cause new or worsened cases of vitamin B12 deficiency. If you have a low vitamin B12 level, talk with your doctor to determine whether Dexilant is safe for you.
• Lupus: There are rare reports of PPIs, including Dexilant, causing new or worsened cases of lupus as a side effect. If you have lupus, talk with your doctor before taking Dexilant.
• Osteoporosis or at risk of developing it: Dexilant and other PPIs may cause or worsen osteoporosis. Your doctor may suggest taking a vitamin D and calcium supplement to strengthen your bones if you are at risk of osteoporosis and need to take Dexilant. They may suggest a treatment for your condition other than Dexilant if you have osteoporosis.
• Allergic reaction: If you’ve had an allergic reaction to Dexilant or any of its ingredients, your doctor will likely not prescribe Dexilant. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better options for you.
• Breastfeeding: It’s not known whether it’s safe to use Dexilant while breastfeeding. There isn’t enough information to determine whether the drug passes into breast milk or what effects Dexilant may have on a child who is breastfed. If you’re breastfeeding or planning to breastfeed, talk with your doctor before using Dexilant. They can talk with you about treatment options and ways to feed your child.
• Pregnancy: There haven’t been enough clinical trials to determine whether Dexilant is safe to use while pregnant. If you’re pregnant or planning to become pregnant, tell your doctor before starting Dexilant. They can advise you on the right treatment plan for you.

FAQ about Dexilant and interactions

Here are some frequently asked questions about Dexilant and possible interactions.

Can I take Dexilant and Omeprazole together?

No, you should not take Dexilant with omeprazole or any other proton pump inhibitor (PPI). Dexilant is a PPI, and taking more than one PPI will not work better to treat the symptoms of your condition. But it does raise your risk of side effects from PPIs, including diarrhea, abdominal pain, and gas.

Talk with your doctor if you feel Dexilant isn’t working for your symptoms. They can help develop a treatment plan for you.

Can I take Dexilant with antibiotics?

It depends on the specific antibiotic. Certain antibiotics can interact with Dexilant, while others may be safe to take with it.

The antibiotics clarithromycin, cefuroxime, and rifampin can interact with Dexilant. To learn about this interaction, see the “Drug interactions in depth ” section in this article.

Other antibiotics are likely safe to take with Dexilant. But always check with your doctor or pharmacist. Be sure they are aware of all medications you take, including Dexilant. If you’re prescribed an antibiotic, they can check whether it interacts with any medications you are taking.

Preventing interactions

You can take certain steps to help prevent interactions with Dexilant. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

• Let them know if you drink alcohol or use cannabis.
• Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
• Create a medication list, which your doctor and pharmacist can help you fill out.

It’s also important to read the Dexilant label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Dexilant doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

You can also help prevent interactions with Dexilant by taking it exactly as your doctor prescribes.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.