Tibsovo (ivosidenib) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat certain types of cancer. Specifically, Tibsovo is approved to treat:
- newly diagnosed acute myeloid leukemia (AML) in certain adults ages 75 years or older
- relapsed or refractory AML in adults*
- bile duct cancer, also called cholangiocarcinoma, in adults
Tibsovo comes as an oral tablet. It belongs to a group of drugs called isocitrate dehydrogenase-1 blockers.
At this time, Tibsovo is only available in the brand-name form. There are currently no generic versions.
* Relapsed cancer refers to cancer that was previously treated and came back. Refractory cancer refers to AML that hasn’t responded to treatment.
Dosage summary chart
The following chart summarizes Tibsovo’s dosage. Your doctor will determine the dosage that’s best for you.
|Tibsovo form||Strength||Typical dosage|
|oral tablet||250 milligrams (mg)||500 mg once per day|
For information about the dosage of Tibsovo in adults, including the drug’s strength and how to take the medication, keep reading. For a comprehensive look at Tibsovo, see this article.
This article describes typical dosages for Tibsovo provided by the drug’s manufacturer. When taking Tibsovo, always follow the dosage prescribed by your doctor.
Below is information on the dosages of Tibsovo for the conditions it’s approved to treat. Before you start taking Tibsovo, your doctor will discuss the dosage, frequency, and timing of your doses.
Tibsovo comes as an oral tablet.
Tibsovo comes in one strength: 250 milligrams (mg).
Most people who take Tibsovo will be prescribed the same dosage by their doctor. Sometimes, your doctor will adjust your dose if you experience side effects or take drugs that may interact with Tibsovo. (To learn more, see the “Factors that can affect your dosage” section below.)
Unlike many other cancer treatments, your Tibsovo dosage is not based on your weight. So there isn’t a Tibsovo dosage chart or dosage calculation that your doctor will use to determine your dosage.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
Dosage for acute myeloid leukemia
The recommended dosage of Tibsovo to treat acute myeloid leukemia (AML) is 500 mg once daily.
If you have newly diagnosed AML, your doctor may prescribe Tibsovo alone or with the drug Onureg (azacitidine).
If you have AML that’s relapsed (has been treated and came back) or is refractory (hasn’t responded to treatment), you’ll take Tibsovo on its own.
Dosage for bile duct cancer
The recommended dosage of Tibsovo to treat bile duct cancer is 500 mg once daily.
Tibsovo is meant to be used as a long-term treatment. In fact, your doctor will likely recommend you continue Tibsovo treatment for at least 6 months. This is because Tibsovo may take up to 6 months to work. You’ll take Tibsovo for this amount of time unless you develop serious side effects from the drug or until your cancer progresses.
If you and your doctor determine that Tibsovo is safe and effective for you, you’ll likely take it long term.
The Tibsovo dosage your doctor prescribes will depend on several factors. These include:
- side effects that you experience from Tibsovo (to learn more, see this article)
- other medications that you may take, which can interact with Tibsovo (for details, see this article)
Other medical conditions you have can also affect your Tibsovo dosage.
In some cases, your doctor may adjust your dosage of Tibsovo. For example, certain medications called CYP3A4 blockers may interact with Tibsovo. This can increase your risk of side effects from the drug. Your doctor or pharmacist can review your current medications with you to see if any of them may interact with Tibsovo. If you take any CYP3A4 blockers, your doctor may recommend a lower dose of Tibsovo.
Your doctor may also recommend a lower dose of Tibsovo if you develop serious side effects from taking the drug. This includes QT prolongation (a heart rhythm condition).
If you have questions about the best dosage of Tibsovo for you, talk with your doctor or pharmacist.
Tibsovo comes as a tablet that you’ll swallow whole. Do not break, crush, or chew the tablets. Try to take your dose of Tibsovo at about the same time each day. This helps maintain a steady level of the drug in your body so Tibsovo can work effectively.
You can take Tibsovo with or without food. However, do not take it with a high fat meal. This type of meal can increase the amount of Tibsovo that’s in your bloodstream. And this may increase your risk of side effects from the drug.
If you have trouble swallowing tablets, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist for additional administration instructions.
Accessible drug labels and containers
If you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.
If you’re having trouble opening medication bottles, ask your pharmacist about putting Tibsovo in an easy-open container. They also may recommend tools that can make it easier to open bottles.
If you miss your dose of Tibsovo and it’s been more than 12 hours before your next dose is due, take your missed dose as soon as possible.
However, if there are less than 12 hours until your next dose of Tibsovo, do not take the missed dose. Take your next dose at your regularly scheduled time.
If you missed a dose of Tibsovo and you’re not sure when to take your next dose, talk with your doctor or pharmacist. They can help you determine when to take it.
It’s important that you do not use more Tibsovo than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose.
If you take more than the recommended amount of Tibsovo
Call your doctor right away if you believe you’ve taken too much Tibsovo. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.
The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Tibsovo for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.
As with any drug, never change your dosage of Tibsovo without your doctor’s recommendation. If you have questions about the dosage of Tibsovo that’s best for you, talk with your doctor.
Besides learning about dosage, you may want other information about Tibsovo. These additional articles might be helpful:
- More about Tibsovo. For information about other aspects of Tibsovo, refer to this article.
- Side effects. To learn about the side effects of Tibsovo, see this article. You can also look at the Tibsovo prescribing information.
- Details about your condition. For details about cancer, see our cancer hub and list of cancer articles. You can also view our leukemia hub and list of leukemia articles.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.