Ankylosing spondylitis (AS) is an inflammatory arthritis that typically causes inflammation or swelling in the spine’s ligaments and joints. It can cause pain and stiffness, which may worsen over time, leading to vertebrae fusion.

The inflammation associated with AS can be widespread, which means a person can experience symptoms in other areas of the body. One common symptom is fatigue or an extreme feeling of tiredness.

While some treatments focus on reducing pain and stiffness, such as nonsteroidal anti-inflammatory drugs, other treatments and therapies may help reduce fatigue.

Some medications, like Janus kinase inhibitors and biologics, provide systemic therapy that can help reduce inflammatory activity throughout the body, which may help lessen fatigue.

The following infographic shows some quick facts about treatments for AS that can help reduce fatigue.

Lifestyle changes

Certain lifestyle changes can help decrease fatigue, including eating a balanced diet, regular exercise, managing weight, and changing sleeping habits, which can all help improve energy levels.

Systemic treatments

Biologics and disease-modifying antirheumatic drugs can help reduce overall inflammation, which may reduce disease activity and lessen symptoms, such as fatigue.

Ongoing research

Researchers are looking into new and better AS treatment options that may reduce fatigue, such as tumor necrosis factor inhibitors and secukinumab (Cosentyx).

Physical therapy

Physical therapy can help improve or maintain mobility. But it may also help improve energy levels. Studies show that physical therapy can effectively lower fatigue levels in people with chronic fatigue syndrome, which means it may help lower fatigue associated with AS.

Reducing or quitting smoking

Studies show that smoking links with severe disease activity and lower quality of life due to worsening symptoms, including pain, anxiety, and fatigue.


A person may see a higher quality of life, including reduced fatigue, by following their treatment plan consistently. It is advisable for them to report new symptoms or health concerns to a doctor for adjustment as needed.