Could 'modest' weight loss send type 2 diabetes into remission? A new study suggests that the answer is 'yes.'
Type 2 diabetes is a metabolic condition characterized by the body's inability to sufficiently process glucose (sugar). As a result, blood sugar levels are persistently high.
Usually, doctors prescribe medication and suggest dietary interventions to help individuals keep the symptoms of type 2 diabetes under control.
Yet remission — referring to a drastic decrease or even disappearance of symptoms, allowing people to cease treatment — is possible under certain conditions.
Previously, in 2016, a different study showed that people with diabetes who followed an intensive low calorie diet — amounting to an intake of 624–700 kilocalories per day for a period of 8 weeks — could also experience remission.
But is it possible to send type 2 diabetes into remission through a less demanding dietary intervention? That is the question that sparked the interest of a team of specialists from the University of Cambridge, in the United Kingdom.
'Modest' weight loss may be enough
In a new study — the findings of which appear in the journal Diabetic Medicine — the researchers from Cambridge analyzed data from 867 people aged 40–69 with newly diagnosed type 2 diabetes.
All of these individuals had enrolled in the ADDITION-Cambridge trial, a prospective study that assesses, among other factors, the effectiveness and helpfulness of diabetes screening.
Researchers followed the participants' progress for a period of 5 years. By looking at the cohort's medical data, the Cambridge team found that 257 individuals, or 30% of the participants, had diabetes in remission by the end of the 5-year period.
The point of interest? Participants who had achieved at least 10% weight loss within 5 years of type 2 diabetes diagnosis were more than twice as likely to experience remission at the 5-year follow-up, compared with individuals who had not lost any weight.
"We've known for some time now that it's possible to send diabetes into remission using fairly drastic measures, such as intensive weight loss programs and extreme calorie restriction," notes first author Hajira Dambha-Miller, Ph.D.
Yet, she adds, "These interventions can be very challenging to individuals and difficult to achieve."
"But, our results suggest that it may be possible to get rid of diabetes, for at least 5 years, with a more modest weight loss of 10%. This will be more motivating and hence more achievable for many people."
Hajira Dambha-Miller, Ph.D.
According to the study's senior author, Prof. Simon Griffin, the current findings emphasize how important consistent dietary and lifestyle interventions are in managing — and even reversing — diabetes.
"This reinforces the importance of managing one's weight, which can be achieved through changes in diet and increasing physical activity. Type 2 diabetes, while a chronic disease, can lead to significant complications, but as our study shows, can be controlled and even reversed," he says.
While this research does offer more hope for individuals with type 2 diabetes, and the researchers suggest that remission "is achievable" with moderate weight loss, other studies have shown that remission rates tend to remain very low.
For instance, earlier this year, a study of 10,059 individuals with type 2 diabetes found that, at the end of the 8-year study period, only 4.97% of these participants had achieved remission.
Going forward, Dambha-Miller and colleagues are planning to find out how healthcare professionals can best support individuals with type 2 diabetes to achieve weight loss and maintain a healthy weight, in view of this intervention's role in reducing diabetes symptoms.
To do so, they have set up the Glucose Lowering through Weight Management (GLoW) study, the aim of which is "to find out whether a tailored diabetes education and behavioral weight management program" would serve patients better than the current, education-only program offered by the U.K.'s National Health Service.
The researchers are currently recruiting participants for GLoW.