Bryhali is a brand-name prescription medication. It’s FDA-approved to treat plaque psoriasis in adults.

Plaque psoriasis is an autoimmune condition, and it’s the most common type of psoriasis. With this condition, you get thick, scaly, red patches on your skin. Plaque psoriasis often affects the scalp, knees, elbows, and lower back.

Bryhali contains the active drug halobetasol, which belongs to a class of drugs called corticosteroids. A drug class is a group of medications that work in a similar way.

The exact way Bryhali works to treat psoriasis is unknown. However, it’s believed that Bryhali affects the way your immune system works. It may also affect certain proteins in the body. This helps reduce how much inflammation (swelling or damage) occurs in your body. Having less inflammation can help relieve symptoms of plaque psoriasis.

Bryhali comes as a lotion that’s applied to affected areas of the body.

Effectiveness

For more information on the effectiveness of Bryhali, see the “Bryhali uses” section below.

Bryhali is available only as a brand-name medication. It’s not currently available in generic form.

A generic drug is an exact copy of the active drug in a brand-name medication. Generics usually cost less than brand-name drugs.

Bryhali contains the active drug halobetasol.

Bryhali comes as a lotion that’s applied to affected areas of the body. Per 1 g of lotion, Bryhali lotion contains 0.1 mg (0.01%) of the active drug, halobetasol.

For more information about how the Bryhali lotion is used, see the “Bryhali uses” and “Bryhali dosage” sections below.

The Food and Drug Administration (FDA) approves prescription drugs such as Bryhali to treat certain conditions. Bryhali may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.

Bryhali for plaque psoriasis

Bryhali is approved to treat plaque psoriasis in adults. Plaque psoriasis is an autoimmune condition. This kind of condition occurs when your immune system attacks healthy cells in the body.

Plaque psoriasis is the most common type of psoriasis. With this condition, you have thick, scaly, red patches on your skin. Plaque psoriasis often affects the scalp, knees, elbows, and lower back.

Effectiveness for plaque psoriasis

Clinical studies of adults with plaque psoriasis compared Bryhali with a placebo (a treatment with no active drug). After 8 weeks:

  • 37% to 38% of people using Bryhali reported that their skin was clear or almost clear of psoriasis
  • 8% to 12% of those using a placebo reported that their skin was clear or almost clear of psoriasis.

For more information on Bryhali’s effectiveness, see the drug’s prescribing information.

Bryhali for other conditions

In addition to the use listed above, Bryhali may be used off-label for other purposes. Off-label drug use is when a drug that’s approved for one or more uses is prescribed for a different one that’s not approved. And you may wonder if Bryhali is used for certain other conditions. Below is information on other possible uses for Bryhali.

Bryhali for eczema (off-label use)

Bryhali isn’t FDA-approved to treat eczema. However, topical corticosteroids like Bryhali are sometimes used off-label to treat moderate to severe eczema. (Topical drugs are applied to the skin.)

Treatment guidelines recommend the use of a corticosteroid such as halobetasol (the active drug in Bryhali) for eczema. The type of corticosteroid you may be prescribed depends on where the eczema is on your body and how bad it is. Talk with your doctor if you’re interested in using Bryhali off-label to treat eczema.

Bryhali for acne (not a known use)

Bryhali isn’t FDA-approved to treat acne. It’s also not included in any treatment guidelines for acne. Bryhali shouldn’t be used on the face, mouth, or around the eyes, which are places where acne can occur.

If you have questions about treatments for your acne, talk with your doctor.

Bryhali and children

Bryhali isn’t approved for use in children. This drug has only been studied in adults, so it’s not known whether this drug is safe or effective for use in children. However, children who are exposed to strong corticosteroids like Bryhali may have a higher risk for side effects. These side effects include Cushing’s syndrome, which can cause slowed growth in children. (See the “Bryhali side effects” section below).

To learn about plaque psoriasis treatments that are safe for children, talk with your doctor.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Bryhali comes as a lotion that’s applied to affected areas of the body. Bryhali lotion contains 0.1 mg (0.01%) of the active drug, halobetasol, per 1 g of lotion.

Dosage for plaque psoriasis

The typical dose for Bryhali is a thin application to the affected area(s) of the body once a day.

What if I miss a dose?

To help make sure you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Don’t use Bryhali more than once a day unless instructed to do so by your doctor.

Will I need to use this drug long term?

Bryhali is typically used for up to 8 weeks. Your doctor will determine how long you should use Bryhali.

Bryhali can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Bryhali. These lists don’t include all possible side effects.

For more information on the possible side effects of Bryhali, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to report to the FDA a side effect you’ve had with Bryhali, you can do so through MedWatch.

Mild side effects

Mild side effects of Bryhali can include:*

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from Bryhali. To learn about other mild side effects, talk with your doctor or pharmacist, or view Bryhali’s prescribing information.
† For more information on this side effect, see “Side effect details” below.
‡ In clinical trials, thinning of the skin, stretch marks, and spider veins were not side effects reported by people using Bryhali. However, these side effects have happened with other corticosteroids (the drug class Bryhali belongs to).

Serious side effects

Serious side effects from Bryhali aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

  • Cataracts (clouding of the lens of the eye) and glaucoma (increased pressure in the eye). Symptoms may vary depending on your condition but may include:
  • Hypothalamic-pituitary-adrenal (HPA) axis suppression.* This condition occurs when your adrenal glands aren’t working properly.
  • Hyperglycemia* (high blood sugar level).
  • Skin infection.*
  • Allergic reaction.*
  • Cushing’s syndrome. This is a hormonal condition that occurs when your cortisol levels are too high. Symptoms can include:
    • weight gain, especially in the face and around the belly
    • a fatty hump between the shoulders
    • bruising easily
    • stretch marks
    • muscle weakness
    • mood changes

* For more information on these side effects, see “Side effect details” below.

Side effect details

You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Here’s some detail on certain side effects this drug may or may not cause.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Bryhali. Symptoms of a mild allergic reaction can include:

  • skin rash
  • itchiness
  • flushing (warmth and redness in your skin)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under your skin, typically in your eyelids, lips, hands, or feet
  • swelling of your tongue, mouth, or throat
  • trouble breathing

Call your doctor right away if you have a severe allergic reaction to Bryhali. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

HPA axis suppression

Using Bryhali may cause hypothalamic-pituitary-adrenal (HPA) axis suppression in some people.

With this condition, your adrenal glands don’t work properly and your body can’t make enough cortisol. Cortisol is a hormone that helps you respond to stress. It also controls important functions like your metabolism (all of the chemical reactions in your body).

In clinical studies, 15.8% of people using Bryhali experienced HPA axis suppression. It’s not known how often this side effect occurred in people taking a placebo (a treatment with no active drug).

Symptoms of HPA axis suppression can include fever, chills, headache, fatigue (lack of energy), diarrhea and abdominal (belly) cramping.

If you have a history of adrenal problems, talk with your doctor before taking Bryhali.

Skin reactions

Some people may have skin reactions after taking Bryhali. In clinical studies:

  • 1% of people using Bryhali experienced a skin reaction
  • 0% of people using a placebo experienced a skin reaction

Symptoms of skin reactions can include:

  • dry, swollen, or red skin where Bryhali is applied
  • irritation to the areas of skin where Bryhali is applied
  • changes to the skin, including lightening of skin color and thinning of the skin, in areas where Bryhali is applied
  • stretch marks
  • spider veins

If you experience a skin reaction during your treatment that’s bothersome, talk with your doctor.

Infections

Bryhali can cause skin infections, including fungal infections. Infections can also happen if you put bandages or wrappings over the area of skin where you applied Bryhali.

Using Bryhali for a long period of time may also raise your risk for an infection.

Symptoms of a skin infection can include:

  • flushing (warmth and redness in your skin)
  • new sores on the skin

It’s not known how often this side effect occurred in clinical trials of people taking Bryhali.

If you’re concerned about skin infections during your Bryhali treatment, talk with your doctor.

Upper respiratory infections

Bryhali can also cause upper respiratory infections, such as the common cold.

In clinical studies:

  • 2% of people using Bryhali had an upper respiratory infection
  • 1% of people using a placebo had an upper respiratory infection

Talk with your doctor about ways to lower your risk for getting upper respiratory infections while using Bryhali.

Hyperglycemia

Taking Bryhali may raise some people’s blood sugar. In clinical studies:

  • 1% of people using Bryhali had increased blood sugar
  • 0% of those using a placebo had increased blood sugar

Symptoms of high blood sugar can include being more thirsty than usual, urinating more often than usual, headache, fatigue, or mood changes.

If you have diabetes or are concerned about your risk for high blood sugar, talk with your doctor before taking Bryhali.

Other drugs are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Bryhali, talk with your doctor. They can tell you about other medications that may work well for you.

Note: Some of the drugs listed here are used off-label to treat these specific conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.

Alternatives for plaque psoriasis

Examples of other drugs that may be used to treat plaque psoriasis include:

You may wonder how Bryhali compares with other medications that are prescribed for similar uses. Here we look at how Bryhali and clobetasol are alike and different.

Ingredients

Bryhali is a brand-name drug that contains the active drug halobetasol. Clobetasol is a generic drug that’s also available as several brand-name drugs, including Clobex, Cormax, Olux, and Temovate.

A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. Generic medications usually cost less than brand-name medications.

Uses

Bryhali and clobetasol are both FDA-approved to treat plaque psoriasis in adults.

Clobetasol is also approved to treat:

  • inflammation (swelling) and itching from various skin conditions in adults

Drug forms and administration

Both Bryhali and clobetasol come as a lotion that’s applied to the skin.

Clobetasol also comes in several other forms, including as a cream, gel, ointment, foam, and spray. These other forms are available as generic or as brand-name drugs, including Clobex, Cormax, Olux, and Temovate.

Bryhali is typically applied once a day. Clobetasol is usually applied twice a day.

Side effects and risks

Bryhali and clobetasol have some similar side effects and other that vary. Below are examples of these side effects.

Mild side effects

These lists contain up to 10 of the most common mild side effects that can occur with Bryhali, with clobetasol, or with both drugs (when taken individually.

* In clinical trials, thinning of the skin, spider veins, and stretch marks were not side effects reported by people using Bryhali. However, skin thinning has happened with other corticosteroids (the drug class Bryhali belongs to).

Serious side effects

These lists contain examples of serious side effects that can occur with Bryhali, with clobetasol, or with both drugs (when taken individually).

  • Can occur with Bryhali:
    • cataracts (clouding of the lens of the eye) and glaucoma (increased pressure in the eye)
  • Can occur with clobetasol:
    • no unique serious side effects
  • Can occur with both Bryhali and clobetasol:
    • hypothalamic-pituitary-adrenal (HPA) axis suppression (when your adrenal glands don’t work properly)

Effectiveness

These drugs haven’t been directly compared in clinical studies. However, studies have found both Bryhali and clobetasol to be effective for treating plaque psoriasis.

Costs

According to estimates on GoodRx.com, Bryhali costs more than clobetasol. The actual price you’ll pay for either drug depends on your insurance plan, your location, and the pharmacy you use.

Bryhali is a brand name drug. Clobetasol is a generic. Generic medications usually cost less than brand-name medications.

Bryhali and Cimzia are prescribed for similar uses. Here’s a look at how these drugs are alike and different.

Ingredients

Bryhali contains the active drug halobetasol. Cimzia contains the active drugcertolizumab pegol.

Uses

Bryhali and Cimzia are both FDA-approved to treat plaque psoriasis in adults. Cimzia is approved to treat moderate to severe plaque psoriasis in adults who may benefit from systemic therapy (drugs taken by mouth or by injection) or phototherapy (light therapy).

Cimzia is also approved to treat:

Drug forms and administration

Bryhali comes as a lotion that you apply to your skin. Cimzia comes as a single-dose prefilled syringe or as a powder that’s mixed with liquid to form a solution. Cimzia is given by subcutaneous injection (injection under the skin).

When you first start using Cimzia, your doctor will give you the injection at their office. They can also teach you how to give yourself injections at home (using the prefilled syringe) if you’d like to start doing it yourself.

Bryhali is typically applied once a day. Cimzia is usually given every 2 weeks for plaque psoriasis.

Side effects and risks

Bryhali and Cimzia have some similar side effects and others that vary. Below are examples of these side effects.

Mild side effects

These lists contain up to 10 of the most common mild side effects that can occur with each drug, or with both Bryhali and Cimzia (when taken individually).

  • Can occur with Bryhali:
    • dry, swollen, or red skin where Bryhali is applied
    • irritation to the areas of the skin where Bryhali is applied
    • changes to the skin, including lightening of skin color and thinning of the skin,* in areas where Bryhali is applied
  • Can occur with Cimzia:
    • headache
    • rash
    • urinary tract infections
    • injection site reaction
    • cough
    • herpes infection
  • Can occur with both Bryhali and Cimzia:

* In clinical trials, thinning of the skin, spider veins, and stretch marks were not side effects reported by people using Bryhali. However, skin thinning has happened with other corticosteroids (the drug class Bryhali belongs to).

Serious side effects

These lists contain examples of serious side effects that can occur with Bryhali, with Cimzia, or with both drugs (when taken individually).

* Cimzia has a boxed warning for these side effects. This is the most serious warning from the Food and Drug Administration (FDA).

Effectiveness

These drugs haven’t been directly compared in clinical studies. However, studies have found both Bryhali and Cimzia to be effective for treating plaque psoriasis.

Costs

According to estimates on GoodRx.com, Bryhali costs less than Cimzia. The actual price you’ll pay for either drug depends on your insurance plan, your location, and if applicable, the pharmacy you use.

Bryhali and Cimzia are both brand-name drugs. There are currently no generic forms of either drug. Brand-name medications usually cost more than generics.

There are no known interactions between Bryhali and alcohol.

If you drink alcohol, talk with your doctor about how much is safe for you to drink during your Bryhali treatment.

Bryhali isn’t known to interact with other medications. It’s also not known to interact with supplements or certain foods.

However, before taking Bryhali, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

As with all medications, the cost of Bryhali can vary.

The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Before approving coverage for Bryhali, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered.

If you’re not sure if you’ll need to get prior authorization for Bryhali, contact your insurance company.

Financial and insurance assistance

If you need financial support to pay for Bryhali, or if you need help understanding your insurance coverage, help is available.

Ortho Dermatologics, the manufacturer of Bryhali, offers the Rx Access Program. If you have commercial insurance, this program may help lower the cost of Bryhali for you. For more information and to find out if you’re eligible for support, call 855-202-3279 or visit the program website.

Generic version

Bryhali isn’t available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.

You should use Bryhali according to your doctor’s or healthcare provider’s instructions.

Bryhali comes as a lotion that’s applied to affected areas of the body. Once you apply Bryhali, rub it gently into your skin.

Bryhali shouldn’t be used on the following areas of the body: face, groin, armpits, mouth, eyes, or inside the vagina. After you use Bryhali, avoid wrapping, bandaging, or blocking the area where you applied it.

When to use

Bryhali is typically applied to the skin once a day. To help make sure you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Bryhali is FDA-approved to treat plaque psoriasis in adults.

About plaque psoriasis

Plaque psoriasis is an autoimmune condition and the most common type of psoriasis. With this condition, thick, scaly, red patches appear on the skin. Plaque psoriasis often affects the scalp, knees, elbows, and lower back.

What Bryhali does

Bryhali is a corticosteroid. Corticosteroids help reduce the amount of inflammation (swelling and damage) in your body. The exact way Bryhali works to treat psoriasis is unknown. However, it’s believed that Bryhali affects the way your immune system works. It may also affect certain proteins in the body. Having less inflammation can help relieve symptoms of plaque psoriasis.

How long does it take to work?

Bryhali starts working right away. However, it may take up to 2 weeks to see an improvement in your plaque psoriasis.

It isn’t known if Bryhali is safe to use during pregnancy.Animal studies have shown some risk to the fetus when Bryhali is given to a pregnant female. However, animal studies don’t always predict what will happen with humans.

Talk with your doctor right away if you become pregnant, or think you may be pregnant, while taking Bryhali. Also talk with your doctor before starting Bryhali if you’re planning a pregnancy.

It’s not known if Bryhali is safe to take during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re using Bryhali.

For more information about taking Bryhali during pregnancy, see the “Bryhali and pregnancy” section above.

It’s not known if Bryhali passes into breast milk or if it’s safe to use while breastfeeding If you’re considering Bryhali treatment while breastfeeding, talk with your doctor about the benefits and risks.

If your doctor advises you to use Bryhali while breastfeeding, don’t apply Bryhali to your nipple or areola to avoid getting it in your baby’s mouth.

Here are answers to some frequently asked questions about Bryhali.

Will Bryhali cure my plaque psoriasis?

No, Bryhali doesn’t cure plaque psoriasis. There is currently no cure for this disease. However, using Bryhali can help relieve psoriasis symptoms such as redness and plaque scales.

If my psoriasis hasn’t gone away after my 8-week Bryhali treatment, should I keep using Bryhali?

No, you shouldn’t keep taking Bryhali for longer than your doctor recommends. In most cases, you’ll take Bryhali for 8 weeks.

Talk with your doctor if your psoriasis hasn’t gone away after your 8-week Bryhali treatment.

Where on my body can I apply Bryhali?

Apply Bryhali to areas of your body affected by your psoriasis. However, Bryhali shouldn’t be used on the following areas of the body: face, groin, armpits, mouth, eyes, or inside the vagina.

Once you apply Bryhali, rub it gently into your skin. After you use Bryhali, avoid wrapping, bandaging, or blocking the area where you applied it, as this could cause infection. (See the “Bryhali side effects” section to learn more.)

Talk with your doctor if you have questions about how or where to apply Bryhali.

Will Bryhali make my skin thinner?

It’s not likely. In clinical trials, Bryhali didn’t cause thinning of the skin. However, thinning of the skin is possible with corticosteroid use (and Bryhali is a corticosteroid).

Talk with your doctor if you’re concerned about your skin getting thinner with use of Bryhali.

Is Bryhali a steroid?

Yes. Bryhali is a corticosteroid, which is a type of steroid. Corticosteroids are a natural hormone steroid that work with your body’s immune system to help reduce inflammation (swelling and damage).

Corticosteroids are different from anabolic steroids. Anabolic steroids are a human-made version of the male sex hormone. These steroids are often used to build muscle.

After applying Bryhali, should I put a bandage over it?

No. Don’t bandage or cover the area of the skin where you apply Bryhali unless your doctor tells you to. Wrapping, bandaging, or blocking the area where you applied Bryhali could cause infection. (See the “Bryhali side effects” section to learn more.)

Before taking Bryhali, talk with your doctor about your health history. Bryhali may not be right for you if you have certain medical conditions or other factors affecting your health. These include:

  • Hypothalamic-pituitary-adrenal (HPA) axis suppression. Using Bryhali may cause HPA axis suppression in some people. With this condition, your adrenal glands don’t work properly and you can’t make enough cortisol. If you already have this condition, using Bryhali could make it worse. Therefore, you shouldn’t use Bryhali if you currently have HPA axis suppression or have had adrenal problems in the past. Symptoms of HPA axis suppression may include depression, anxiety, sensitivity to cold,fatigue, andinsomnia. If you experience symptoms of adrenal problems during your treatment, tell your doctor right away.
  • Diabetes. Bryhali can raise your blood sugar. If you already have a condition related to high blood sugar, such as diabetes, using Bryhali could raise your blood sugar even more. Talk with your doctor before starting Bryhali if you have diabetes or have a history of hyperglycemia (high blood sugar).
  • Liver problems. You shouldn’t take Bryhali if you have liver problems. Liver problems may affect how your body breaks down Bryhali. This could cause too much Bryhali to build up in your body.
  • Skin infection. If you have an active skin infection, you may need to treat it before starting Bryhali. (An active infection means you currently have symptoms.) Tell your doctor right away if you develop a skin infection while taking Bryhali.
  • Allergic reaction. If you’ve had an allergic reaction to Bryhali or any of its ingredients, you shouldn’t take Bryhali. Ask your doctor which other medications are better options for you.
  • Pregnancy. It isn’t known if Bryhali is safe to use during pregnancy. For more information, see the “Bryhali and pregnancy” section above.
  • Breastfeeding. It’s not known if it’s safe to breastfeed while taking Bryhali. For more information, see the “Bryhali and breastfeeding” section above.

Note: For more information about the potential negative effects of Bryhali, see the “Bryhali side effects” section above.

Do not use more Bryhali than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose.

What to do in case you use too much Bryhali

If you think you’ve used too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

When you get Bryhali from the pharmacy, the pharmacist will add an expiration date to the label on the packaging. This date is typically 1 year from the date they dispensed the medication.

The expiration date helps guarantee that the medication is effective during this time. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it.

Storage

How long a medication remains good can depend on many factors, including how and where you store the medication.

Bryhali lotion should be stored at a room temperature of 68°F to 77°F (20°C to 25°C). It should be stored in its original container.

Disposal

If you no longer need to take Bryhali and have leftover lotion, it’s important to dispose of it safely. This helps prevent others, including children and pets, from taking the drug by accident. It also helps keep the drug from harming the environment.

This article provides several useful tips on medication disposal. You can also ask your pharmacist for information on how to dispose of your medication.

The following information is provided for clinicians and other healthcare professionals.

Indications

Bryhali is indicated for the topical treatment of plaque psoriasis in adults.

Administration

Bryhali is a lotion applied topically to affected areas once daily.

Mechanism of action

Bryhali’s precise mechanism of action in plaque psoriasis is not known. Corticosteroids play a role in immune function to regulate proteins and decrease inflammation to reduce symptoms of plaque psoriasis.

Pharmacokinetics and metabolism

Bryhali steady-state concentration is reached by day 14.

Contraindications

Bryhali does not have any contraindications. Use caution in people with a history of serious hypersensitivity reaction to the drug or any of its components.

Storage

Bryhali should be stored at a room temperature of 68°F to 77°F (20°C to 25°C). Excursions are permitted at temperatures of 59°F to 86°F (15°C to 30°C). Do not freeze.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.